Pre_GI: BLASTP Hits

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Query: NC_017179:1378875:1386367 Clostridium difficile BI1, complete genome

Start: 1386367, End: 1386828, Length: 462

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:1370000:137659313765931377054462Clostridium difficile CD196 chromosome, complete genomehypothetical protein5e-83305
NC_016627:2799453:282162828216282822089462Clostridium clariflavum DSM 19732 chromosome, complete genomehypothetical protein5e-42169
NC_011898:513835:520889520889521347459Clostridium cellulolyticum H10, complete genomeprotein of unknown function DUF1502e-41167
NC_010001:3369500:338240133824013382868468Clostridium phytofermentans ISDg, complete genomeprotein of unknown function DUF1502e-38157
NC_014152:1430156:143960514396051440066462Thermincola sp. JR, complete genomeprotein of unknown function DUF1501e-36151
NC_014376:3214222:322642632264263226893468Clostridium saccharolyticum WM1 chromosome, complete genomeprotein of unknown function DUF1502e-36151
NC_019970:1343670:135513813551381355593456Thermoanaerobacterium thermosaccharolyticum M0795, complete genomehypothetical protein5e-34143
NC_014387:1175927:118407311840731184537465Butyrivibrio proteoclasticus B316 chromosome 1, complete genomehypothetical protein2e-33141
NC_014103:3985897:399935039993503999820471Bacillus megaterium DSM319 chromosome, complete genomehypothetical protein1e-32138
NC_013216:3376186:339157833915783392039462Desulfotomaculum acetoxidans DSM 771, complete genomeprotein of unknown function DUF1502e-31134
NC_009253:2139379:215169421516942152155462Desulfotomaculum reducens MI-1 chromosome, complete genomehypothetical protein2e-30131
NC_015589:1899329:191460519146051915066462Desulfotomaculum ruminis DSM 2154 chromosome, complete genomehypothetical protein7e-30129
NC_004722:3777907:378941537894153789885471Bacillus cereus ATCC 14579, complete genomehypothetical protein2e-29127
NC_007907:2879568:288786528878652888323459Desulfitobacterium hafniense Y51, complete genomehypothetical protein2e-29127
NC_011725:3821789:383330038333003833770471Bacillus cereus B4264 chromosome, complete genomehypothetical protein2e-29127
NC_014171:3701051:371256037125603713030471Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein2e-29127
NC_011830:3904034:391515239151523915610459Desulfitobacterium hafniense DCB-2, complete genomeprotein of unknown function DUF1505e-29126
NC_010184:3675424:368734536873453687815471Bacillus weihenstephanensis KBAB4, complete genomeprotein of unknown function DUF1505e-29126
NC_011772:3787500:379902237990223799492471Bacillus cereus G9842, complete genomehypothetical protein5e-29126
NC_017208:3816753:382865638286563829126471Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein5e-29126
NC_006274:3697255:370914037091403709610471Bacillus cereus E33L, complete genomehypothetical protein7e-29125
NC_003909:3587695:360131836013183601788471Bacillus cereus ATCC 10987, complete genomehypothetical protein7e-29125
NC_012472:3661912:367342036734203673890471Bacillus cereus 03BB102, complete genomehypothetical protein7e-29125
NC_005957:3638750:365025836502583650728471Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein7e-29125
NC_007530:3616828:362871436287143629184471Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein7e-29125
NC_003997:3617000:362858736285873629057471Bacillus anthracis str. Ames, complete genomehypothetical protein7e-29125
NC_009674:2551759:256331825633182563788471Bacillus cytotoxicus NVH 391-98 chromosome, complete genomehypothetical protein9e-29125
NC_008600:3643905:365541336554133655937525Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein9e-29125
NC_014335:3567931:357943935794393579909471Bacillus cereus biovar anthracis str. CI chromosome, completenus operon associated protein7e-29125
NC_005945:3615623:362928236292823629752471Bacillus anthracis str. Sterne, complete genomehypothetical protein7e-29125
NC_017200:3655496:367031736703173670787471Bacillus thuringiensis serovar finitimus YBT-020 chromosome,ribosome maturation protein RimP7e-29125
NC_016779:3579743:359125135912513591721471Bacillus cereus F837/76 chromosome, complete genomehypothetical protein7e-29125
NC_016771:3555506:356912835691283569598471Bacillus cereus NC7401, complete genomehypothetical protein7e-29125
NC_012659:3617000:362861436286143629084471Bacillus anthracis str. A0248, complete genomehypothetical protein7e-29125
NC_012581:559182:609503609503609973471Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein7e-29125
NC_011969:3549000:356059335605933561063471Bacillus cereus Q1 chromosome, complete genomehypothetical protein7e-29125
NC_011773:3651963:366347336634733663943471Bacillus cereus AH820 chromosome, complete genomehypothetical protein7e-29125
NC_011658:3603009:361663136166313617101471Bacillus cereus AH187 chromosome, complete genomehypothetical protein7e-29125
NC_014657:944000:954015954015954470456Caldicellulosiruptor owensensis OL chromosome, complete genomehypothetical protein8e-28122
NC_020134:1173000:117672311767231177187465Clostridium stercorarium subsp. stercorarium DSM 8532, completeribosome maturation factor RimP5e-27119
NC_010516:2511035:254082525408252541286462Clostridium botulinum B1 str. Okra, complete genomehypothetical protein6e-26116
NC_010520:2585014:261535526153552615816462Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein7e-26115
NC_012658:2584355:261073326107332611194462Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein2e-25114
NC_007350:1551457:155774115577411558208468Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305,hypothetical protein2e-25114
NC_009495:2524000:255260225526022553063462Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein5e-25113
NC_009697:2394826:242462524246252425086462Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein5e-25113
NC_009698:2367171:239697023969702397431462Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein5e-25113
NC_004461:921364:946899946899947366468Staphylococcus epidermidis ATCC 12228, complete genomehypothetical protein3e-25113
NC_007622:1214629:122349612234961223963468Staphylococcus aureus RF122, complete genomehypothetical protein1e-24112
NC_002952:1291444:130031113003111300778468Staphylococcus aureus subsp. aureus MRSA252, complete genomehypothetical protein1e-24112
NC_017338:1234077:124064412406441241111468Staphylococcus aureus subsp. aureus JKD6159 chromosome, completehypothetical protein1e-24112
NC_017341:1291583:130045013004501300917468Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,hypothetical protein1e-24112
NC_009782:1327340:133620713362071336674468Staphylococcus aureus subsp. aureus Mu3, complete genomehypothetical protein1e-24112
NC_012563:2721658:272711227271122727573462Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-24112
NC_012121:897866:906678906678907145468Staphylococcus carnosus subsp. carnosus TM300, complete genomehypothetical protein2e-24111
NC_017353:1699652:171074417107441711211468Staphylococcus lugdunensis N920143, complete genomehypothetical protein8e-24109
NC_020291:1464500:146823314682331468694462Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeribosome maturation factor RimP1e-23108
NC_020419:344000:351858351858352313456Uncultured Termite group 1 bacterium phylotype Rs-D17 DNA, completehypothetical protein5e-22103
NC_014727:1292213:131541313154131315889477Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,ribosome maturation factor rimp5e-22103
NS_000191:344000:351858351858352313456Uncultured Termite group 1 bacterium phylotype Rs-D17, completehypothetical protein5e-22103
NC_013861:311908:326710326710327153444Legionella longbeachae NSW150, complete genomehypothetical protein7e-22102
NC_015682:1457004:147734814773481477815468Thermodesulfobacterium sp. OPB45 chromosome, complete genomeRibosome maturation factor rimP4e-2097.1
NC_010730:578493:589256589256589699444Sulfurihydrogenibium sp. YO3AOP1, complete genomeprotein of unknown function DUF1503e-2097.1
NC_014328:1405484:141022414102241410688465Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein5e-2096.3
NC_006368:3211998:321348832134883213946459Legionella pneumophila str. Paris, complete genomehypothetical protein8e-2095.9
NC_009465:29735:538085380854269462Candidatus Vesicomyosocius okutanii HA, complete genomehypothetical protein1e-1995.5
NC_021150:4311902:432337643233764323813438Azotobacter vinelandii CA6, complete genomehypothetical protein2e-1994.7
NC_012560:4311906:432338043233804323817438Azotobacter vinelandii DJ, complete genomehypothetical protein2e-1994.7
NC_002971:1379567:138620713862071386668462Coxiella burnetii RSA 493, complete genomehypothetical protein2e-1994.7
NC_010117:1461502:146678814667881467249462Coxiella burnetii RSA 331, complete genomeconserved hypothetical protein2e-1994.7
NC_011528:535680:547248547248547709462Coxiella burnetii CbuK_Q154, complete genomehypothetical cytosolic protein2e-1994.7
NC_011527:525759:540611540611541072462Coxiella burnetii CbuG_Q212, complete genomehypothetical cytosolic protein2e-1994.7
NC_006369:3058000:307154330715433072001459Legionella pneumophila str. Lens, complete genomehypothetical protein4e-1993.6
NC_009654:1123709:114194111419411142402462Marinomonas sp. MWYL1, complete genomehypothetical protein5e-1993.2
NC_007645:1245927:124959212495921250113522Hahella chejuensis KCTC 2396, complete genomehypothetical protein7e-1992.8
NC_004129:957890:971334971334971810477Pseudomonas fluorescens Pf-5, complete genomehypothetical protein7e-1992.8
NC_005139:2731623:275049927504992750954456Vibrio vulnificus YJ016 chromosome I, complete sequencehypothetical protein7e-1992.8
NC_015968:4117835:412208141220814122533453Enterobacter asburiae LF7a chromosome, complete genomeribosome maturation factor rimP3e-1890.5
NC_012438:159927:171132171132171575444Sulfurihydrogenibium azorense Az-Fu1 chromosome, complete genomehypothetical protein4e-1890.5
NC_012440:197728:206942206942207397456Persephonella marina EX-H1, complete genomehypothetical protein4e-1890.1
NC_003112:1685330:170541217054121705861450Neisseria meningitidis MC58, complete genomehypothetical protein6e-1889.7
NC_013517:2437574:245560924556092456082474Sebaldella termitidis ATCC 33386, complete genomeprotein of unknown function DUF1506e-1889.7
NC_011852:211314:217115217115217522408Haemophilus parasuis SH0165, complete genomehypothetical protein8e-1889.4
NC_014833:3362500:338240533824053382950546Ruminococcus albus 7 chromosome, complete genomehypothetical protein2e-1787.8
NC_020063:528296:550394550394550846453Enterobacteriaceae bacterium strain FGI 57, complete genomehypothetical protein2e-1787.8
NC_017161:1:212052120521678474Hydrogenobacter thermophilus TK-6 chromosome, complete genomehypothetical protein9e-1785.9
NC_013799:1:211442114421617474Hydrogenobacter thermophilus TK-6, complete genomehypothetical protein9e-1785.9
NC_015318:706374:714379714379714801423Hippea maritima DSM 10411 chromosome, complete genomeRibosome maturation factor rimP3e-1684.3
NC_012880:3915500:392172839217283922150423Dickeya dadantii Ech703, complete genomeprotein of unknown function DUF1504e-1683.6
NC_010336:996661:102081410208141021266453Francisella philomiragia subsp. philomiragia ATCC 25017, completehypothetical protein7e-1682.8
NC_009749:1699152:174155617415561742008453Francisella tularensis subsp. holarctica FTA, complete genomehypothetical protein9e-1682.4
NC_008601:1733940:177715817771581777610453Francisella tularensis subsp. novicida U112, complete genomehypothetical protein9e-1682.4
NC_007880:1703346:174565917456591746111453Francisella tularensis subsp. holarctica, complete genomehypothetical protein9e-1682.4
NC_009257:109528:133632133632134084453Francisella tularensis subsp. tularensis WY96-3418 chromosome,hypothetical protein9e-1682.4
NC_008245:24652:487324873249190459Francisella tularensis subsp. tularensis FSC 198, complete genomehypothetical protein9e-1682.4
NC_008369:1702885:174528917452891745747459Francisella tularensis subsp. holarctica OSU18, complete genomehypothetical protein9e-1682.4
NC_006570:24636:487164871649174459Francisella tularensis subsp. tularensis Schu 4, complete genomehypothetical protein9e-1682.4
NC_016933:24654:487344873449192459Francisella tularensis TIGB03 chromosome, complete genomehypothetical protein9e-1682.4
NC_016937:24654:487344873449192459Francisella tularensis subsp. tularensis TI0902 chromosome,hypothetical protein9e-1682.4
NC_008021:1374195:137901513790151379551537Streptococcus pyogenes MGAS9429, complete genomehypothetical cytosolic protein1e-1582
NC_007297:1379742:138456213845621385098537Streptococcus pyogenes MGAS5005, complete genomehypothetical protein1e-1582
NC_008023:1398085:140290514029051403441537Streptococcus pyogenes MGAS2096, complete genomehypothetical cytosolic protein1e-1582
NC_013161:3448966:345711334571133457574462Cyanothece sp. PCC 8802, complete genomeprotein of unknown function DUF1502e-1581.6
NC_011726:2793669:280388428038842804345462Cyanothece sp. PCC 8801, complete genomeprotein of unknown function DUF1502e-1581.6
NC_016632:74569:893428934289758417Serratia symbiotica str. 'Cinara cedri' chromosome, completeribosome maturation protein2e-1581.6
NC_010677:96470:120571120571121023453Francisella tularensis subsp. mediasiatica FSC147, complete genomeprotein Lpl26913e-1580.5
NC_014758:1349494:136095613609561361429474Calditerrivibrio nitroreducens DSM 19672 chromosome, completehypothetical protein4e-1580.1
NC_013170:917177:923023923023923556534Cryptobacterium curtum DSM 15641, complete genomehypothetical protein7e-1579.7
NC_017294:758992:776847776847777308462Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomeribosome maturation factor rimP8e-1579.3
NC_015696:517941:542275542275542727453Francisella sp. TX077308 chromosome, complete genomeclustered with transcription termination protein NusA1e-1478.6
NC_009718:799431:799431799431799889459Fervidobacterium nodosum Rt17-B1, complete genomehypothetical protein1e-1478.6
NC_010546:1853825:186487418648741865329456Cyanothece sp. ATCC 51142 chromosome circular, complete sequenceDUF150-containing protein2e-1477.8
NC_019771:3237000:324129432412943241755462Anabaena cylindrica PCC 7122, complete genomeRibosome maturation factor rimP2e-1477.8
NC_014501:5832879:584359658435965844057462Cyanothece sp. PCC 7822 chromosome, complete genomehypothetical protein3e-1477.4
NC_019435:747162:763223763223763696474Lactococcus lactis subsp. cremoris UC509.9, complete genomeHypothetical protein6e-1476.6
NC_008527:740060:756119756119756592474Lactococcus lactis subsp. cremoris SK11, complete genomehypothetical protein5e-1476.6
NC_002163:129800:139820139820140242423Campylobacter jejuni subsp. jejuni NCTC 11168, complete genomehypothetical protein5e-1476.6
NC_010628:7128951:714129271412927141753462Nostoc punctiforme PCC 73102, complete genomeprotein of unknown function DUF1504e-1476.6
NC_017048:1018000:102849710284971028982486Rickettsia prowazekii str. GvV257 chromosome, complete genomeribosome maturation protein RimP6e-1476.3
NC_017049:675261:684455684455684940486Rickettsia prowazekii str. Chernikova chromosome, complete genomeribosome maturation protein RimP6e-1476.3
NC_017050:676000:686324686324686809486Rickettsia prowazekii str. Katsinyian chromosome, complete genomeribosome maturation protein RimP6e-1476.3
NC_017051:674000:684467684467684952486Rickettsia prowazekii str. Dachau chromosome, complete genomeribosome maturation protein RimP6e-1476.3
NC_017057:679113:686587686587687072486Rickettsia prowazekii str. RpGvF24 chromosome, complete genomeribosome maturation protein RimP6e-1476.3
NC_017066:683000:692827692827693312486Rickettsia typhi str. TH1527 chromosome, complete genomeribosome maturation protein RimP1e-1375.5
NC_017062:685321:693395693395693880486Rickettsia typhi str. B9991CWPP chromosome, complete genomeribosome maturation protein RimP1e-1375.5
NC_006142:683000:692815692815693300486Rickettsia typhi str. Wilmington, complete genomehypothetical protein1e-1375.5
NC_009004:1770497:177548617754861775959474Lactococcus lactis subsp. cremoris MG1363, complete genomeconserved hypothetical protein2e-1374.7
NC_014166:455378:468328468328468756429Arcobacter nitrofigilis DSM 7299 chromosome, complete genomehypothetical protein2e-1374.7
NC_017056:678450:686301686301686786486Rickettsia prowazekii str. BuV67-CWPP chromosome, complete genomeribosome maturation protein RimP2e-1374.7
NC_009663:2023941:204286720428672043295429Sulfurovum sp. NBC37-1, complete genomehypothetical protein2e-1374.3
NC_014774:239865:252824252824253384561Candidatus Liberibacter solanacearum CLso-ZC1 chromosome, completehypothetical protein4e-1373.6
NC_017058:671000:677088677088677555468Rickettsia australis str. Cutlack chromosome, complete genomeribosome maturation protein RimP7e-1372.8
NC_014248:619500:624489624489624950462Nostoc azollae 0708 chromosome, complete genomehypothetical protein9e-1372.4
NC_017187:1923733:192794319279431928371429Arcobacter butzleri ED-1, complete genomehypothetical protein9e-1372.4
NC_007940:669143:674357674357674899543Rickettsia bellii RML369-C, complete genomehypothetical protein1e-1272
NC_009883:641491:646705646705647247543Rickettsia bellii OSU 85-389, complete genomehypothetical protein1e-1272
NC_011653:1728000:172930917293091729755447Thermosipho africanus TCF52B, complete genomehypothetical protein1e-1272
NC_000963:676000:686462686462686815354Rickettsia prowazekii str. Madrid E, complete genomehypothetical protein2e-1271.2
NC_007413:2312735:232345923234592323920462Anabaena variabilis ATCC 29413, complete genomehypothetical protein2e-1270.9
NC_009881:724269:736813736813737313501Rickettsia akari str. Hartford, complete genomehypothetical protein3e-1270.9
NC_012985:465354:471064471064471642579Candidatus Liberibacter asiaticus str. psy62, complete genomehypothetical protein3e-1270.5
NC_013943:1381000:138685413868541387363510Denitrovibrio acetiphilus DSM 12809 chromosome, complete genomehypothetical protein5e-1270.1
NC_016050:771752:781283781283781768486Rickettsia japonica YH, complete genomehypothetical protein8e-1269.3
NC_015866:767790:777206777206777691486Rickettsia heilongjiangensis 054 chromosome, complete genomeribosome maturation protein RimP8e-1269.3
NC_015672:1566565:158088415808841581360477Flexistipes sinusarabici DSM 4947 chromosome, complete genomeribosome maturation factor rimP1e-1168.9
NC_013771:803042:820170820170820547378Cyanobacterium UCYN-A, complete genomehypothetical protein1e-1168.6
NC_010263:771901:781533781533782018486Rickettsia rickettsii str. Iowa, complete genomehypothetical cytosolic protein1e-1168.6
NC_016909:771542:781173781173781658486Rickettsia rickettsii str. Arizona chromosome, complete genomeribosome maturation protein RimP1e-1168.6
NC_016911:771916:781548781548782033486Rickettsia rickettsii str. Hauke chromosome, complete genomeribosome maturation protein RimP1e-1168.6
NC_016914:772025:781657781657782142486Rickettsia rickettsii str. Hino chromosome, complete genomeribosome maturation protein RimP1e-1168.6
NC_011295:847903:852531852531853040510Coprothermobacter proteolyticus DSM 5265, complete genomeprotein of unknown function, putative2e-1167.8
NC_012039:185607:199277199277199699423Campylobacter lari RM2100, complete genomeconserved hypothetical protein (DUF150 domain protein)4e-1167
NC_003272:4621554:462755746275574628018462Nostoc sp. PCC 7120, complete genomehypothetical protein5e-1166.6
NC_016603:3475843:347962134796213480145525Acinetobacter calcoaceticus PHEA-2 chromosome, complete genomehypothetical protein8e-1165.9
NC_009879:475500:481400481400481777378Rickettsia canadensis str. McKiel, complete genomehypothetical protein9e-1062.4
NC_010296:1271393:128006712800671280537471Microcystis aeruginosa NIES-843, complete genomeYhbC family protein1e-0962
NC_010003:570643:576091576091576564474Petrotoga mobilis SJ95, complete genomeprotein of unknown function DUF1504e-0960.5
NC_015161:758929:764271764271764723453Deinococcus proteolyticus MRP chromosome, complete genomeRibosome maturation factor rimP6e-0856.6
NC_014759:2883500:288616428861642886637474Marivirga tractuosa DSM 4126 chromosome, complete genomehypothetical protein1e-0755.5
NC_019673:7738588:774317777431777743701525Saccharothrix espanaensis DSM 44229 complete genomeRibosome maturation factor RimP2e-0755.1
NC_013939:1535071:154936815493681549844477Deferribacter desulfuricans SSM1, complete genomehypothetical protein3e-0753.9
NC_005042:1480761:150439015043901504857468Prochlorococcus marinus subsp. marinus str. CCMP1375, completeUncharacterized YhbC family conserved protein3e-0753.9