Pre_GI: BLASTP Hits

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Query: NC_017179:1133510:1146125 Clostridium difficile BI1, complete genome

Start: 1146125, End: 1146352, Length: 228

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:1123733:113634811363481136575228Clostridium difficile CD196 chromosome, complete genomeacyl carrier protein4e-34143
NC_017179:1239991:125101812510181251242225Clostridium difficile BI1, complete genomeacyl carrier protein1e-24112
NC_013315:1230214:124124012412401241464225Clostridium difficile CD196 chromosome, complete genomeacyl carrier protein1e-24112
NC_013316:1225797:123885712388571239081225Clostridium difficile R20291, complete genomeacyl carrier protein1e-24112
NC_015958:1422319:142996714299671430194228Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeacyl carrier protein3e-1890.5
NC_014964:1309845:131814813181481318375228Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeacyl carrier protein3e-1890.5
NC_011661:961129:972510972510972749240Dictyoglomus turgidum DSM 6724, complete genomeacyl carrier protein3e-1890.5
NC_014328:1379437:138056913805691380802234Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative acyl carrier protein4e-1890.1
NC_011297:787932:801672801672801911240Dictyoglomus thermophilum H-6-12, complete genomeacyl carrier protein8e-1889
NC_020291:1437431:143851214385121438742231Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeacyl carrier protein AcpP5e-1786.3
NC_009495:2571732:258896125889612589203243Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeacyl carrier protein7e-1785.9
NC_017297:2635892:263780526378052638038234Clostridium botulinum F str. 230613 chromosome, complete genomeacyl carrier protein9e-1785.5
NC_012563:2761570:276348327634832763716234Clostridium botulinum A2 str. Kyoto, complete genomeacyl carrier protein9e-1785.5
NC_010516:2567911:257718625771862577419234Clostridium botulinum B1 str. Okra, complete genomeacyl carrier protein9e-1785.5
NC_010520:2635750:265198826519882652221234Clostridium botulinum A3 str. Loch Maree, complete genomeacyl carrier protein9e-1785.5
NC_009698:2420484:243332824333282433561234Clostridium botulinum A str. Hall chromosome, complete genomeacyl carrier protein9e-1785.5
NC_009699:2635745:263765826376582637891234Clostridium botulinum F str. Langeland chromosome, complete genomeacyl carrier protein9e-1785.5
NC_012658:2641446:264720326472032647436234Clostridium botulinum Ba4 str. 657 chromosome, complete genomeacyl carrier protein9e-1785.5
NC_014624:2668157:268098526809852681209225Eubacterium limosum KIST612 chromosome, complete genomeacyl carrier protein3e-1684
NC_013893:1723939:173843317384331738666234Staphylococcus lugdunensis HKU09-01 chromosome, complete genomeAcyl carrier protein/HmrB protein involved in methicillin resistance1e-1582
NC_020164:1590221:160577316057731606006234Staphylococcus warneri SG1, complete genomeacyl carrier protein1e-1582
NC_017353:1750971:176182217618221762055234Staphylococcus lugdunensis N920143, complete genomeacyl carrier protein1e-1582
NC_012438:50845:520955209552328234Sulfurihydrogenibium azorense Az-Fu1 chromosome, complete genomeacyl carrier protein9e-1682
NC_018664:1699618:171068917106891710916228Clostridium acidurici 9a chromosome, complete genomeacyl carrier protein AcpP2e-1580.9
NC_007517:1792000:180287918028791803112234Geobacter metallireducens GS-15, complete genomeAcyl carrier protein (ACP)4e-1580.1
NC_010730:1724443:173493417349341735167234Sulfurihydrogenibium sp. YO3AOP1, complete genomeacyl carrier protein4e-1580.1
NC_013517:2633574:263648126364812636702222Sebaldella termitidis ATCC 33386, complete genomeacyl carrier protein5e-1579.7
NC_007498:1666242:168547316854731685706234Pelobacter carbinolicus DSM 2380, complete genomeacyl carrier protein6e-1579.7
NC_016584:4860360:489431048943104894537228Desulfosporosinus orientis DSM 765 chromosome, complete genomeacyl carrier protein6e-1579.3
NC_019903:2708500:271731827173182717545228Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,acyl carrier protein9e-1579
NC_002973:1846000:186041518604151860648234Listeria monocytogenes str. 4b F2365, complete genomeacyl carrier protein8e-1579
NC_011830:4031901:405663240566324056859228Desulfitobacterium hafniense DCB-2, complete genomeacyl carrier protein1e-1478.6
NC_007907:2995889:302914130291413029368228Desulfitobacterium hafniense Y51, complete genomehypothetical protein1e-1478.6
NC_012121:837586:852430852430852663234Staphylococcus carnosus subsp. carnosus TM300, complete genomeacyl carrier protein1e-1478.2
NC_013939:148706:157707157707157943237Deferribacter desulfuricans SSM1, complete genomeacyl carrier protein ACP2e-1477.8
NC_020419:870160:881481881481881720240Uncultured Termite group 1 bacterium phylotype Rs-D17 DNA, completeacyl carrier protein AcpP2e-1477.8
NS_000191:870160:881481881481881720240Uncultured Termite group 1 bacterium phylotype Rs-D17, completeacyl carrier protein AcpP2e-1477.8
NC_015499:1466794:147997914799791480224246Thermodesulfobium narugense DSM 14796 chromosome, complete genomeAcyl carrier protein2e-1477.4
NC_011296:102650:106286106286106522237Thermodesulfovibrio yellowstonii DSM 11347, complete genomeacyl carrier protein3e-1477
NC_014622:2114244:212996621299662130199234Paenibacillus polymyxa SC2 chromosome, complete genomeacyl carrier protein4e-1476.6
NC_014483:1954856:197056519705651970798234Paenibacillus polymyxa E681 chromosome, complete genomeAcyl carrier protein (ACP)4e-1476.6
NC_010644:718748:725171725171725416246Elusimicrobium minutum Pei191, complete genomeacyl carrier protein6e-1476.3
NC_008369:1083598:108493710849371085275339Francisella tularensis subsp. holarctica OSU18, complete genomeacyl carrier protein8e-1475.9
NC_010655:1160384:116553911655391165781243Akkermansia muciniphila ATCC BAA-835, complete genomeacyl carrier protein1e-1375.5
NC_008319:136863:140177140177140461285Synechococcus sp. CC9311, complete genomeacyl carrier protein1e-1375.1
NC_002947:2157648:215859221585922158828237Pseudomonas putida KT2440, complete genomeacyl carrier protein1e-1375.1
NC_008245:1405000:142170614217061421990285Francisella tularensis subsp. tularensis FSC 198, complete genomeacyl carrier protein1e-1375.1
NC_010677:707881:709584709584709868285Francisella tularensis subsp. mediasiatica FSC147, complete genomeacyl carrier protein1e-1375.1
NC_007880:1079634:108097310809731081257285Francisella tularensis subsp. holarctica, complete genomeacyl carrier protein1e-1375.1
NC_006570:1405178:142190014219001422184285Francisella tularensis subsp. tularensis Schu 4, complete genomeacyl carrier protein1e-1375.1
NC_008601:1404933:141940314194031419687285Francisella tularensis subsp. novicida U112, complete genomeacyl carrier protein1e-1375.1
NC_016933:1481000:149767214976721497956285Francisella tularensis TIGB03 chromosome, complete genomeacyl carrier protein1e-1375.1
NC_016937:1405000:142176514217651422049285Francisella tularensis subsp. tularensis TI0902 chromosome,acyl carrier protein1e-1375.1
NC_015391:1013608:101687710168771017119243Carnobacterium sp. 17-4 chromosome, complete genomeacyl carrier protein3e-1373.9
NC_007484:1823751:185806018580601858296237Nitrosococcus oceani ATCC 19707, complete genomeAcyl carrier protein (ACP)6e-1372.8
NC_004193:1558551:156928615692861569519234Oceanobacillus iheyensis HTE831, complete genomeacyl carrier proteins6e-1372.8
NC_010336:1468760:147045614704561470698243Francisella philomiragia subsp. philomiragia ATCC 25017, completeacyl carrier protein8e-1372.4
NC_010382:1607013:161253716125371612782246Lysinibacillus sphaericus C3-41, complete genomeAcyl carrier protein (ACP)1e-1271.6
NC_016112:2301023:232042823204282320658231Methylomicrobium alcaliphilum chromosome, complete genomeacyl carrier protein2e-1271.2
NC_019978:1410041:141930414193041419531228Halobacteroides halobius DSM 5150, complete genomeacyl carrier protein2e-1271.2
NC_016024:1876000:188391818839181884172255Candidatus Chloracidobacterium thermophilum B chromosome chromosomeacyl carrier protein2e-1271.2
NC_009848:1542978:154634315463431546576234Bacillus pumilus SAFR-032, complete genomeacyl carrier protein3e-1270.9
NC_006155:2893802:291580529158052916041237Yersinia pseudotuberculosis IP 32953, complete genomeacyl carrier protein4e-1270.1
NC_007298:2170181:217192421719242172160237Dechloromonas aromatica RCB, complete genomeAcyl carrier protein (ACP)5e-1269.7
NC_009091:1514770:152261415226141522853240Prochlorococcus marinus str. MIT 9301, complete genomeacyl carrier protein (ACP)5e-1269.7
NC_015276:2171355:219110621911062191339234Marinomonas mediterranea MMB-1 chromosome, complete genomeAcyl carrier protein5e-1269.7
UCMB5137:1159520:116504011650401165273234Bacillus atrophaeus UCMB-5137acyl carrier protein5e-1269.7
NC_008599:1325155:134454413445441344777234Campylobacter fetus subsp. fetus 82-40, complete genomeacyl carrier protein7e-1269.3
NC_014103:4059905:406447040644704064703234Bacillus megaterium DSM319 chromosome, complete genomeacyl carrier protein7e-1269.3
NC_010278:1989500:200364620036462003951306Actinobacillus pleuropneumoniae serovar 3 str. JL03 chromosome,acyl carrier protein6e-1269.3
NC_016050:1088223:110048311004831100743261Rickettsia japonica YH, complete genomeacyl carrier protein6e-1269.3
NC_017042:1206000:121553712155371215782246Rickettsia rhipicephali str. 3-7-female6-CWPP chromosome, completeacyl carrier protein6e-1269.3
NC_007929:653814:668401668401668643243Lactobacillus salivarius subsp. salivarius UCC118, complete genomeAcyl carrier protein9e-1268.9
NC_010939:2085000:209911920991192099352234Actinobacillus pleuropneumoniae serovar 7 str. AP76, completeacyl carrier protein9e-1268.9
NC_009053:2025782:204196220419622042195234Actinobacillus pleuropneumoniae L20, complete genomeacyl carrier protein9e-1268.9
NC_008817:1574506:158237815823781582620243Prochlorococcus marinus str. MIT 9515, complete genomeacyl carrier protein (ACP)2e-1168.2
NC_008025:430487:448998448998449228231Deinococcus geothermalis DSM 11300, complete genomeacyl carrier protein1e-1168.2
NC_016913:83988:933189331893563246Rickettsia rickettsii str. Brazil chromosome, complete genomeacyl carrier protein2e-1167.8
NC_012778:1778654:179518617951861795416231Eubacterium eligens ATCC 27750, complete genomeacyl carrier protein2e-1167.8
NC_011027:136954:147559147559147798240Chlorobaculum parvum NCIB 8327, complete genomeacyl carrier protein2e-1167.8
NC_007645:2181739:219612521961252196358234Hahella chejuensis KCTC 2396, complete genomeacyl carrier protein2e-1167.4
NC_017281:388610:409939409939410172234Campylobacter jejuni subsp. jejuni S3 chromosome, complete genomeacyl carrier protein3e-1167.4
NC_003912:426676:447970447970448203234Campylobacter jejuni RM1221, complete genomeacyl carrier protein3e-1167.4
NC_008054:1194000:119411911941191194361243Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completeAcyl carrier protein (ACP)3e-1167.4
NC_014958:3393855:340804434080443408274231Deinococcus maricopensis DSM 21211 chromosome, complete genomeAcyl carrier protein4e-1166.6
NC_008787:390215:411488411488411721234Campylobacter jejuni subsp. jejuni 81-176, complete genomeacyl carrier protein4e-1166.6
NC_017280:387760:409046409046409279234Campylobacter jejuni subsp. jejuni M1 chromosome, complete genomeacyl carrier protein4e-1166.6
NC_003909:3606177:364136936413693641602234Bacillus cereus ATCC 10987, complete genomeacyl carrier protein7e-1165.9
NC_005957:3665657:368764236876423687875234Bacillus thuringiensis serovar konkukian str. 97-27, completeacyl carrier protein7e-1165.9
NC_011772:3821917:383640938364093836642234Bacillus cereus G9842, complete genomeacyl carrier protein7e-1165.9
NC_014335:3589726:361682436168243617057234Bacillus cereus biovar anthracis str. CI chromosome, completeacyl carrier protein7e-1165.9
NC_007530:3616828:366609536660953666328234Bacillus anthracis str. 'Ames Ancestor', complete genomeacyl carrier protein7e-1165.9
NC_003997:3617000:366596836659683666201234Bacillus anthracis str. Ames, complete genomeacyl carrier protein7e-1165.9
NC_006274:3736703:374652637465263746759234Bacillus cereus E33L, complete genomeacyl carrier protein7e-1165.9
NC_008600:3686135:369546636954663695708243Bacillus thuringiensis str. Al Hakam, complete genomeacyl carrier protein7e-1165.9
NC_009718:643200:683695683695683919225Fervidobacterium nodosum Rt17-B1, complete genomeacyl carrier protein8e-1165.9
NC_012472:3705500:371347237134723713705234Bacillus cereus 03BB102, complete genomeacyl carrier protein7e-1165.9
NC_005945:3636321:366666336666633666896234Bacillus anthracis str. Sterne, complete genomeacyl carrier protein7e-1165.9
NC_017208:3816753:386608438660843866317234Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeacyl carrier protein7e-1165.9
NC_017200:3701043:371037437103743710607234Bacillus thuringiensis serovar finitimus YBT-020 chromosome,acyl carrier protein7e-1165.9
NC_016779:3621973:363130336313033631536234Bacillus cereus F837/76 chromosome, complete genomeacyl carrier protein7e-1165.9
NC_016771:3599170:360651636065163606749234Bacillus cereus NC7401, complete genomeacyl carrier protein7e-1165.9
NC_012659:3617000:366599536659953666228234Bacillus anthracis str. A0248, complete genomeacyl carrier protein7e-1165.9
NC_012581:559182:572358572358572591234Bacillus anthracis str. CDC 684 chromosome, complete genomeacyl carrier protein7e-1165.9
NC_011773:3689473:370085937008593701092234Bacillus cereus AH820 chromosome, complete genomeacyl carrier protein7e-1165.9
NC_011725:3862094:387069238706923870925234Bacillus cereus B4264 chromosome, complete genomeacyl carrier protein7e-1165.9
NC_011658:3603009:365401836540183654251234Bacillus cereus AH187 chromosome, complete genomeacyl carrier protein7e-1165.9
NC_016632:951500:958204958204958443240Serratia symbiotica str. 'Cinara cedri' chromosome, completeacyl carrier protein9e-1165.5
NC_010184:3713359:372474437247443724977234Bacillus weihenstephanensis KBAB4, complete genomeacyl carrier protein9e-1165.5
NC_010831:173499:175632175632175868237Chlorobium phaeobacteroides BS1, complete genomeacyl carrier protein1e-1065.1
NC_010673:703816:747737747737748000264Borrelia hermsii DAH, complete genomeacyl carrier protein2e-1064.3
NC_008710:703740:744979744979745242264Borrelia turicatae 91E135, complete genomeacyl carrier protein2e-1063.9
NC_011244:746801:759261759261759524264Borrelia recurrentis A1, complete genomeacyl carrier protein3e-1063.9
NC_008593:37456:435144351443744231Clostridium novyi NT, complete genomeacyl carrier protein4e-1063.5
NC_017187:1923733:194165319416531941883231Arcobacter butzleri ED-1, complete genomeacyl carrier protein3e-1063.5
NC_015275:3299923:331225133122513312475225Clostridium lentocellum DSM 5427 chromosome, complete genomeacyl carrier protein5e-1063.2
NC_015425:34861:427914279143021231Clostridium botulinum BKT015925 chromosome, complete genomeacyl carrier protein6e-1062.8
NC_016605:1033000:104423510442351044477243Pediococcus claussenii ATCC BAA-344 chromosome, complete genomeacyl carrier protein9e-1062.4
NC_008095:4669947:468158246815824681812231Myxococcus xanthus DK 1622, complete genomeacyl carrier protein2e-0961.2
NC_014844:3015738:303118830311883031424237Desulfovibrio aespoeensis Aspo-2 chromosome, complete genomeacyl carrier protein3e-0960.5
NC_005125:2456889:247494724749472475258312Gloeobacter violaceus PCC 7421, complete genomeacyl carrier protein5e-0959.7
NC_017323:599549:637829637829638077249Sinorhizobium meliloti BL225C plasmid pSINMEB02, complete sequenceacyl carrier protein6e-0959.7
NC_018681:2447871:247261324726132472912300Nocardia brasiliensis ATCC 700358 chromosome, complete genomeacyl carrier protein8e-0959.3
NC_008278:7409711:743118774311877431972786Frankia alni ACN14a, complete genomeacyl carrier protein (partial match)6e-0959.3
NC_009921:6447151:645453564545356454771237Frankia sp. EAN1pec, complete genomeacyl carrier protein1e-0858.9
NC_008726:3968222:399591339959133996212300Mycobacterium vanbaalenii PYR-1, complete genomephosphopantetheine-binding1e-0858.5
NC_014168:2820315:282271828227182823104387Segniliparus rotundus DSM 44985 chromosome, complete genomephosphopantetheine-binding protein1e-0858.5
NC_013928:395028:416706416706416930225Streptococcus mutans NN2025, complete genomeacyl carrier protein3e-0857
NC_014393:4988127:500075150007515000975225Clostridium cellulovorans 743B chromosome, complete genomephosphopantetheine-binding5e-0856.6
NC_017295:3762622:377649437764943776724231Clostridium acetobutylicum EA 2018 chromosome, complete genomeAcyl Carrier Protein, ACP7e-0855.8
NC_003030:3763054:377714237771423777372231Clostridium acetobutylicum ATCC 824, complete genomeAcyl Carrier Protein, ACP7e-0855.8
NC_015687:3766000:377872537787253778955231Clostridium acetobutylicum DSM 1731 chromosome, complete genomeacyl carrier protein7e-0855.8
NC_010723:1133163:114010011401001140324225Clostridium botulinum E3 str. Alaska E43, complete genomeacyl carrier protein homolog2e-0754.3
NC_013928:9494:305793057930827249Streptococcus mutans NN2025, complete genomeacyl carrier protein2e-0754.3
NC_012563:4101000:411463941146394114863225Clostridium botulinum A2 str. Kyoto, complete genomeacyl carrier protein7e-0752.8
NC_010520:3938490:395211539521153952339225Clostridium botulinum A3 str. Loch Maree, complete genomeacyl carrier protein7e-0752.8
NC_009495:3832500:384612138461213846345225Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeacyl carrier protein7e-0752.8
NC_009697:3809044:382265538226553822879225Clostridium botulinum A str. ATCC 19397 chromosome, completeacyl carrier protein7e-0752.8
NC_009698:3706154:371976537197653719989225Clostridium botulinum A str. Hall chromosome, complete genomeacyl carrier protein7e-0752.8
NC_009699:3940984:395459939545993954823225Clostridium botulinum F str. Langeland chromosome, complete genomeacyl carrier protein7e-0752.8
NC_012658:3923546:393717539371753937399225Clostridium botulinum Ba4 str. 657 chromosome, complete genomeacyl carrier protein7e-0752.8
NC_017297:3939328:395294239529423953166225Clostridium botulinum F str. 230613 chromosome, complete genomeacyl carrier protein-like protein7e-0752.8
NC_010674:1170264:117620311762031176427225Clostridium botulinum B str. Eklund 17B, complete genomeacyl carrier protein homolog9e-0752.4
NC_010516:3903867:391747539174753917699225Clostridium botulinum B1 str. Okra, complete genomeacyl carrier protein2e-0650.8
NC_012926:30351:303513035130599249Streptococcus suis BM407 chromosome, complete genomeacyl carrier protein3e-0650.4
NC_012924:29353:303533035330601249Streptococcus suis SC84, complete genomeacyl carrier protein3e-0650.4
NC_009443:29349:303493034930597249Streptococcus suis 98HAH33, complete genomeAcyl carrier protein3e-0650.4
NC_012925:29353:303533035330601249Streptococcus suis P1/7, complete genomeacyl carrier protein3e-0650.4
NC_015703:2281479:229422322942232294462240Runella slithyformis DSM 19594 chromosome, complete genomephosphopantetheine-binding protein4e-0650.1
NC_004668:2762464:276246427624642762691228Enterococcus faecalis V583, complete genomeacyl carrier protein6e-0649.7
NC_016938:1492486:150220415022041502434231Melissococcus plutonius DAT561 chromosome 1, complete genomeacyl carrier protein8e-0649.3
NC_015391:1323171:133814813381481338378231Carnobacterium sp. 17-4 chromosome, complete genomeacyl carrier protein8e-0649.3
NC_014148:4037357:404181140418114042197387Planctomyces limnophilus DSM 3776 chromosome, complete genomephosphopantetheine-binding protein9e-0648.9