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Query: NC_017179:1133510:1144977 Clostridium difficile BI1, complete genome

Start: 1144977, End: 1145981, Length: 1005

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:1123733:1135200113520011362041005Clostridium difficile CD196 chromosome, complete genomehypothetical protein0664
NC_009089:1093832:110417811041781105173996Clostridium difficile 630, complete genomephage protein6e-127454
NC_016627:3659500:3660568366056836615931026Clostridium clariflavum DSM 19732 chromosome, complete genomenucleoid-associated protein1e-51203
NC_020291:5808856:5830296583029658313331038Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein3e-47189
NC_012563:2680246:2686417268641726874421026Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein4e-46185
NC_009699:2552195:2558468255846825594931026Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein3e-44179
NC_017297:2531750:2558608255860825596331026Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein3e-44179
NC_010516:2676746:2701931270193127029801050Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-40166
NC_017297:3428429:3452369345236934534181050Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein6e-39161
NC_009699:3429817:3453755345375534548041050Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein6e-39161
NC_012658:1405788:1408652140865214097011050Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein2e-38160
NC_012563:1681639:1696913169691316979621050Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein4e-38159
NC_009697:2558286:2583575258357525846241050Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein6e-38158
NC_017294:1385576:1406295140629514073321038Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomehypothetical protein7e-33141
NC_015913:1422444:1439899143989914409211023Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomehypothetical protein7e-33141
NC_010418:188138:2012522012522022771026Clostridium botulinum A3 str. Loch Maree plasmid pCLK, completehypothetical protein1e-31137
NC_016012:1312352:1329789132978913308231035Candidatus Arthromitus sp. SFB-rat-Yit, complete genomehypothetical protein5e-30132
NC_014614:2333890:2353835235383523548511017Clostridium sticklandii, complete genomehypothetical protein7e-1891.7
NC_016894:3329562:3335424333542433364311008Acetobacterium woodii DSM 1030 chromosome, complete genomehypothetical protein9e-1581.3
NC_014828:1795781:180536718053671806356990Ethanoligenens harbinense YUAN-3 chromosome, complete genomehypothetical protein4e-1272.4