Pre_GI: BLASTP Hits

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Query: NC_017179:1133510:1133510 Clostridium difficile BI1, complete genome

Start: 1133510, End: 1134310, Length: 801

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:1123733:112373311237331124533801Clostridium difficile CD196 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase3e-154544
NC_014219:1736000:175392517539251754713789Bacillus selenitireducens MLS10 chromosome, complete genomeATP-NAD/AcoX kinase2e-27122
NC_008525:1202852:120285212028521203661810Pediococcus pentosaceus ATCC 25745, complete genomeNAD kinase2e-27122
NC_017219:2014605:2030962203096220319781017Bifidobacterium longum subsp. infantis ATCC 15697, complete genomekinase5e-26118
NC_011593:2014787:2031144203114420321601017Bifidobacterium longum subsp. infantis ATCC 15697 chromosome,inorganic polyphosphate/ATP-NAD kinase5e-26118
NC_011772:4565418:456849145684914569294804Bacillus cereus G9842, complete genomehypothetical protein9e-26117
NC_009513:618000:637328637328638140813Lactobacillus reuteri F275, complete genomeinorganic polyphosphate/ATP-NAD kinase1e-25117
NC_011725:4600000:460317546031754603978804Bacillus cereus B4264 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase1e-25116
NC_015697:1814128:184014818401481840960813Lactobacillus reuteri SD2112 chromosome, complete genomeNAD(+) kinase2e-25115
NC_009699:2056500:206440820644082065253846Clostridium botulinum F str. Langeland chromosome, complete genomeATP-NAD kinase5e-25114
NC_010516:1999500:200734720073472008192846Clostridium botulinum B1 str. Okra, complete genomeATP-NAD kinase5e-25114
NC_014657:1193985:120782212078221208607786Caldicellulosiruptor owensensis OL chromosome, complete genomeATP-nad/acox kinase6e-25114
NC_010520:2061502:207217020721702073015846Clostridium botulinum A3 str. Loch Maree, complete genomeATP-NAD kinase8e-25114
NC_014220:2102000:211246021124602113308849Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeATP-NAD/AcoX kinase5e-24111
NC_017301:1037519:103833710383371039296960Corynebacterium pseudotuberculosis C231 chromosome, completeInorganic polyphosphate/ATP-NAD kinase5e-24111
NC_016783:1169821:117679711767971177735939Corynebacterium diphtheriae INCA 402 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase1e-23110
NC_015978:996933:996149996149996991843Lactobacillus sanfranciscensis TMW 1.1304 chromosome, completeputative inorganic polyphosphate/ATP-NAD kinase3e-23108
NC_016605:766836:786628786628787434807Pediococcus claussenii ATCC BAA-344 chromosome, complete genomeATP-NAD kinase family protein8e-23107
NC_014654:1548194:155707915570791557933855Halanaerobium sp. 'sapolanicus' chromosome, complete genomeATP-NAD/AcoX kinase1e-22106
NC_014041:661352:661352661352662236885Zunongwangia profunda SM-A87 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase5e-22105
NC_016051:1681076:168024316802431681079837Thermococcus sp. AM4 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase7e-22104
NC_005090:1519035:153749715374971538369873Wolinella succinogenes DSM 1740, complete genomeconserved hypothetical protein-Predicted kinase1e-21103
NC_013510:2521186:254485025448502545761912Thermomonospora curvata DSM 43183, complete genomeATP-NAD/AcoX kinase1e-21103
NC_013939:913890:941864941864942712849Deferribacter desulfuricans SSM1, complete genomeNAD(+) kinase4e-21102
NC_012214:1117325:113543711354371136315879Erwinia pyrifoliae Ep1/96, complete genomeProbable inorganic polyphosphate/ATP-NAD kinase3e-21102
NC_015588:1463628:148119314811931482104912Isoptericola variabilis 225 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase2e-21102
NC_009714:224325:261833261833262708876Campylobacter hominis ATCC BAA-381, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-21101
NC_014002:1173561:117436011743601175196837Methanohalophilus mahii DSM 5219 chromosome, complete genomeATP-NAD/AcoX kinase5e-21101
NC_004551:100840:116812116812117729918Tropheryma whipplei TW08/27, complete genomeATP-NAD kinase1e-20100
NC_008563:2909945:290994529099452910823879Escherichia coli APEC O1, complete genomeprobable inorganic polyphosphate/ATP-NAD kinase1e-20100
NC_004431:3012668:301341730134173014295879Escherichia coli CFT073, complete genomeinorganic polyphosphate/ATP-NAD kinase1e-20100
NC_007946:2894793:289491928949192895797879Escherichia coli UTI89, complete genomeprobable inorganic polyphosphate/ATP-NAD kinase1e-20100
NC_014121:4043198:404613840461384047016879Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completeinorganic polyphosphate/ATP-NAD kinase1e-20100
NC_018876:2760000:277822927782292779062834Methanolobus psychrophilus R15 chromosome, complete genomeNAD(+) kinase9e-21100
NC_016514:3573400:357533435753343576287954Enterobacter cloacae EcWSU1 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase8e-21100
NC_009436:3367194:337011633701163370994879Enterobacter sp. 638, complete genomeinorganic polyphosphate/ATP-NAD kinase2e-2099.8
NC_009648:3224495:322661632266163227494879Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeinorganic polyphosphate/ATP-NAD kinase2e-2099.8
NC_016845:4077293:409360040936004094478879Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,inorganic polyphosphate/ATP-NAD kinase2e-2099.8
NC_012804:271459:272530272530273366837Thermococcus gammatolerans EJ3, complete genomeInorganic polyphosphate/ATP-NAD kinase (poly(P)/ATP NAD kinase) (ppnK)2e-2099.8
NC_012803:1552122:1553861155386115549491089Micrococcus luteus NCTC 2665, complete genomepredicted sugar kinase3e-2099
NC_004741:2741971:274400427440042744882879Shigella flexneri 2a str. 2457T, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-2098.6
NC_004337:2747917:274937127493712750249879Shigella flexneri 2a str. 301, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-2098.6
CP002516:1165726:118321511832151184093879Escherichia coli KO11, complete genomeATP-NAD/AcoX kinase4e-2098.6
NC_009800:2788164:279110827911082791986879Escherichia coli HS, complete genomeNAD(+) kinase4e-2098.6
AC_000091:2747520:274948727494872750365879Escherichia coli W3110 DNA, complete genomeNAD kinase4e-2098.6
NC_011748:2973968:297396829739682974846879Escherichia coli 55989, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-2098.6
NC_009801:2898426:290116429011642902042879Escherichia coli E24377A, complete genomeNAD(+) kinase4e-2098.6
NC_013008:3525428:352982535298253530703879Escherichia coli O157:H7 str. TW14359 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-2098.6
NC_011353:3573641:357494835749483575826879Escherichia coli O157:H7 str. EC4115 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-2098.6
NC_002695:3468873:347084034708403471718879Escherichia coli O157:H7 str. Sakai, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-2098.6
NC_002655:3538656:354068935406893541567879Escherichia coli O157:H7 EDL933, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-2098.6
NC_000913:2746886:274885327488532749731879Escherichia coli K12, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-2098.6
AP010958:3238742:323945532394553240333879Escherichia coli O103:H2 str. 12009 DNA, complete genomeNAD kinase4e-2098.6
NC_008258:2905413:291900029190002919878879Shigella flexneri 5 str. 8401, complete genomehypothetical protein4e-2098.6
NC_017328:2785309:278825327882532789131879Shigella flexneri 2002017 chromosome, complete genomeputative inorganic polyphosphate/ATP-NAD kinase4e-2098.6
NC_016902:1165726:118321511832151184093879Escherichia coli KO11FL chromosome, complete genomeATP-NAD/AcoX kinase4e-2098.6
NC_013361:3597812:359977935997793600657879Escherichia coli O26:H11 str. 11368 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-2098.6
NC_013353:3238742:323945532394553240333879Escherichia coli O103:H2 str. 12009, complete genomeNAD kinase4e-2098.6
NC_012967:2669182:267212626721262673004879Escherichia coli B str. REL606 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-2098.6
NC_012947:1106000:112179311217931122671879Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completeinorganic polyphosphate/ATP-NAD kinase4e-2098.6
NC_012759:2633949:263466526346652635543879Escherichia coli BW2952 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-2098.6
NC_011415:3006794:300966330096633010541879Escherichia coli SE11 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-2098.6
CU928145:2973968:297396829739682974846879Escherichia coli 55989 chromosome, complete genomeNAD kinase4e-2098.6
CP002185:2919752:292176429217642922642879Escherichia coli W, complete genomeNAD kinase4e-2098.6
NC_010473:2839902:284061828406182841496879Escherichia coli str. K-12 substr. DH10B, complete genomeNAD kinase4e-2098.6
NC_011740:448000:4636314636314652591629Escherichia fergusonii ATCC 35469, complete genomeinorganic polyphosphate/ATP-NAD kinase7e-2097.8
NC_020064:3609844:361201636120163612894879Serratia marcescens FGI94, complete genomeputative sugar kinase9e-2097.4
NC_015224:3587500:358974235897423590623882Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,inorganic polyphosphate/ATP-NAD kinase2e-1996.3
NC_008800:1090000:112030811203081121189882Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,inorganic polyphosphate/ATP-NAD kinase2e-1996.3
NC_016818:3736213:373982037398203740698879Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completeputative sugar kinase3e-1995.5
NC_012880:3748665:376998237699823770860879Dickeya dadantii Ech703, complete genomeNAD(+) kinase4e-1995.5
NC_016745:1548426:156769715676971568581885Oceanimonas sp. GK1 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-1995.5
NC_004547:913553:931182931182932060879Erwinia carotovora subsp. atroseptica SCRI1043, complete genomeinorganic polyphosphate/ATP-NAD kinase4e-1995.5
NC_012912:3749156:375149837514983752376879Dickeya zeae Ech1591, complete genomeATP-NAD/AcoX kinase6e-1994.7
NC_009792:3665369:366830736683073669113807Citrobacter koseri ATCC BAA-895, complete genomehypothetical protein5e-1994.7
NC_010634:1342393:136115213611521361919768Yersinia pseudotuberculosis PB1/+, complete genomeATP-NAD/AcoX kinase8e-1994.4
NC_004088:3382148:338423833842383385119882Yersinia pestis KIM, complete genomeinorganic polyphosphate/ATP-NAD kinase7e-1994.4
NC_010159:1417993:143385914338591434740882Yersinia pestis Angola, complete genomeNAD(+)/NADH kinase7e-1994.4
NC_005810:1130251:113234111323411133222882Yersinia pestis biovar Microtus str. 91001, complete genomeinorganic polyphosphate/ATP-NAD kinase7e-1994.4
NC_008149:3251196:325328632532863254167882Yersinia pestis Nepal516, complete genomehypothetical protein7e-1994.4
NC_003143:1233128:124970712497071250588882Yersinia pestis CO92, complete genomeinorganic polyphosphate/ATP-NAD kinase7e-1994.4
NC_008150:650899:666443666443667324882Yersinia pestis Antiqua, complete genomehypothetical protein7e-1994.4
NC_017265:1136000:115103711510371151918882Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,ATP-NAD kinase7e-1994.4
NC_017168:4155143:417172341717234172604882Yersinia pestis A1122 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase7e-1994.4
NC_017154:1225500:124099712409971241878882Yersinia pestis D106004 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase7e-1994.4
NC_014029:1283500:129890412989041299785882Yersinia pestis Z176003 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase7e-1994.4
NC_009381:2939782:294187229418722942753882Yersinia pestis Pestoides F chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase7e-1994.4
NC_015061:3725921:372738737273873728265879Rahnella sp. Y9602 chromosome, complete genomeATP-NAD/AcoX kinase9e-1994
NC_012917:833721:849673849673850569897Pectobacterium carotovorum subsp. carotovorum PC1, complete genomeATP-NAD/AcoX kinase1e-1894
NC_013162:811763:824696824696825580885Capnocytophaga ochracea DSM 7271, complete genomeATP-NAD/AcoX kinase1e-1893.6
NC_015222:1749553:177185417718541772726873Nitrosomonas sp. AL212 chromosome, complete genomeATP-NAD/AcoX kinase2e-1893.2
NC_011661:1049767:106342110634211064215795Dictyoglomus turgidum DSM 6724, complete genomeATP-NAD/AcoX kinase3e-1892.4
NC_008312:2690000:269372226937222694651930Trichodesmium erythraeum IMS101, complete genomeNAD(+) kinase3e-1892
NC_012691:2476223:247904324790432479927885Tolumonas auensis DSM 9187, complete genomeATP-NAD/AcoX kinase4e-1891.7
NC_004459:349500:350254350254351138885Vibrio vulnificus CMCP6 chromosome I, complete sequenceinorganic polyphosphate/ATP-NAD kinase2e-1789.7
NC_014833:2225233:222523322252332226096864Ruminococcus albus 7 chromosome, complete genomeATP-NAD/AcoX kinase2e-1789.7
NC_017160:1507500:150973415097341510513780Yersinia pestis D182038 chromosome, complete genomehypothetical protein3e-1789
NC_008819:199760:213039213039213944906Prochlorococcus marinus str. NATL1A, complete genomepredicted inorganic polyphosphate / ATP-NAD+ kinase3e-1789
NC_012668:2744393:274439327443932745277885Vibrio cholerae MJ-1236 chromosome 1, complete sequenceinorganic polyphosphate/ATP-NAD kinase9e-1787.4
NC_009457:351512:409268409268410152885Vibrio cholerae O395 chromosome 2, complete sequenceinorganic polyphosphate/ATP-NAD kinase9e-1787.4
NC_015152:1341353:135525813552581356121864Spirochaeta sp. Buddy chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase3e-1685.9
NC_006370:768745:770592770592771473882Photobacterium profundum SS9 chromosome 1, complete sequenceinorganic polyphosphate/ATP-NAD kinase3e-1685.9
NC_013508:2870954:287276928727692873647879Edwardsiella tarda EIB202, complete genomeinorganic polyphosphate/ATP-NAD kinase6e-1684.7
NC_007335:1474455:148773614877361488644909Prochlorococcus marinus str. NATL2A, complete genomeinorganic polyphosphate/ATP-NAD kinase7e-1684.3
NC_012779:2957000:295777629577762958654879Edwardsiella ictaluri 93-146, complete genomehypothetical protein1e-1584
NC_013926:71186:768817688177669789Aciduliprofundum boonei T469 chromosome, complete genomeATP-NAD/AcoX kinase1e-1583.6
NC_015318:981989:994645994645995541897Hippea maritima DSM 10411 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase2e-1582.8
NC_016041:2420098:242471124247112425586876Glaciecola nitratireducens FR1064 chromosome, complete genomeNAD(+) kinase2e-1582.8
NC_007712:3067000:306712130671213067999879Sodalis glossinidius str. 'morsitans', complete genomehypothetical protein2e-1582.8
NC_007354:1087456:109416610941661094957792Ehrlichia canis str. Jake, complete genomeNAD(+) kinase3e-1582.4
NC_009051:930758:951400951400952212813Methanoculleus marisnigri JR1, complete genomeNAD(+) kinase4e-1582
NC_015677:3520524:353425435342543535150897Ramlibacter tataouinensis TTB310 chromosome, complete genomeinorganic polyphosphate/ATP-NAD kinase3e-1582
NC_007947:797456:814226814226815098873Methylobacillus flagellatus KT, complete genomeNAD(+) kinase6e-1581.3
NC_008752:3955327:397282239728223973718897Acidovorax avenae subsp. citrulli AAC00-1, complete genomeNAD(+) kinase8e-1580.9
NC_010003:1444623:146072114607211461545825Petrotoga mobilis SJ95, complete genomeATP-NAD/AcoX kinase8e-1580.9
NC_014910:1050706:105325110532511054147897Alicycliphilus denitrificans BC chromosome, complete genomeATP-nad/acox kinase2e-1479.7
NC_012026:75812:854618546186282822Anaplasma marginale str. Florida, complete genomeConserved family ATP-NAD kinase called by Glimmer 24e-1478.6
NC_005061:594500:608206608206609087882Candidatus Blochmannia floridanus, complete genomeprobable inorganic polyphosphate/ATP-NAD kinase6e-1478.2
NC_005125:480500:505528505528506460933Gloeobacter violaceus PCC 7421, complete genomeinorganic polyphosphate/ATP-NAD kinase6e-1478.2
NC_014909:619407:621078621078621953876Candidatus Blochmannia vafer str. BVAF chromosome, complete genomeProbable inorganic polyphosphate/ATP-NAD kinase9e-1477.4
NC_010172:573046:599230599230600000771Methylobacterium extorquens PA1, complete genomeNAD(+) kinase1e-1377
NC_011992:863174:865708865708866604897Acidovorax ebreus TPSY, complete genomeATP-NAD/AcoX kinase2e-1376.6
NC_017297:2054000:206450620645062065006501Clostridium botulinum F str. 230613 chromosome, complete genome3e-1375.9
NC_011666:2435438:243881324388132439604792Methylocella silvestris BL2, complete genomeNAD(+) kinase5e-1374.7
NC_008818:702452:707692707692708504813Hyperthermus butylicus DSM 5456, complete genomeATP-NAD kinase2e-1273.6
NC_005042:165530:178921178921179844924Prochlorococcus marinus subsp. marinus str. CCMP1375, completeinorganic polyphosphate/ATP-NAD kinase2e-1273.2
NC_015931:71361:986459864599469825Pyrolobus fumarii 1A, complete genomeATP-NAD/AcoX kinase3e-1272.4
NC_008698:471564:474682474682475560879Thermofilum pendens Hrk 5, complete genomeNAD(+) kinase5e-1271.6
NC_016622:527688:535495535495536373879Azospirillum lipoferum 4B, complete genomeputative NAD kinase2e-1169.3
NC_013922:331847:3836013836013854241824Natrialba magadii ATCC 43099 chromosome, complete genomeinositol monophosphatase4e-1168.9
NC_010125:1:168921689217695804Gluconacetobacter diazotrophicus PAl 5, complete genomeputative inorganic polyphosphate/ATP-NAD kinase4e-1168.6
NC_006677:435652:442263442263443021759Gluconobacter oxydans 621H, complete genomeProbable inorganic polyphosphate/ATP-NAD kinase8e-1064.3
NC_012587:1181004:118530111853011186071771Rhizobium sp. NGR234, complete genomeputative inorganic polyphosphate/ATP-NAD kinase3e-0962.8
NC_008701:1785905:178752017875201788401882Pyrobaculum islandicum DSM 4184, complete genomeATP-NAD/AcoX kinase1e-0860.8
NC_019974:298523:320196320196321020825Natronococcus occultus SP4, complete genomeputative sugar kinase9e-0857.8
NC_018643:673195:705863705863706501639Alpha proteobacterium HIMB5 chromosome, complete genomeATP-NAD kinase1e-0654.3