Pre_GI: BLASTP Hits

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Query: NC_017177:192933:206223 Clostridium difficile BI1, complete genome

Start: 206223, End: 208145, Length: 1923

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014964:2272413:2285184228518422870191836Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completetype IV secretory pathway VirB4 components-like protein6e-111402
NC_014538:2158131:2173861217386121756961836Thermoanaerobacter sp. X513 chromosome, complete genometype IV secretory pathway VirB4 components-like protein6e-110398
NC_015520:2567329:2587205258720525890491845Mahella australiensis 50-1 BON chromosome, complete genomeAAA ATPase7e-73275
NC_014721:2201790:2223973222397322258381866Caldicellulosiruptor kristjanssonii 177R1B chromosome, completeaaa atpase1e-68261
NC_009437:2815500:2832379283237928341511773Caldicellulosiruptor saccharolyticus DSM 8903, complete genomeAAA ATPase6e-65249
NC_013792:109203:1244971244971265002004Bacillus pseudofirmus OF4 plasmid pBpOF4-01, complete sequencehypothetical protein2e-63244
NC_014652:379833:3813053813053831641860Caldicellulosiruptor hydrothermalis 108 chromosome, completeaaa atpase2e-62241
NC_010381:35408:5125251252531471896Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequencehypothetical protein2e-61237
NC_011775:156673:1701331701331722232091Bacillus cereus G9842 plasmid pG9842_209, complete sequencehypothetical protein9e-57222
NC_015687:2145452:2156640215664021584931854Clostridium acetobutylicum DSM 1731 chromosome, complete genomeconjugative transfer TrsE , ATPase5e-55216
NC_015312:1265797:1287412128741212893221911Pseudonocardia dioxanivorans CB1190 chromosome, complete genometype IV secretory pathway VirB4 components-like protein5e-54213
NC_012473:46000:7664576645787352091Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequencehypothetical protein4e-50199
NC_011777:100631:1055611055611076602100Bacillus cereus AH820 plasmid pAH820_272, complete sequencehypothetical protein6e-50199
NC_005707:12735:2623726237283362100Bacillus cereus ATCC 10987 plasmid pBc10987, complete sequencehypothetical protein6e-50199
NC_007322:57710:8936589365914642100Bacillus anthracis str. 'Ames Ancestor' plasmid pXO1, complete4e-49196
NC_012656:67949:8962989629917282100Bacillus anthracis str. A0248 plasmid pXO1, complete sequence4e-49196
NC_012579:72715:8968589685917842100Bacillus anthracis str. CDC 684 plasmid pX01, complete sequencehypothetical protein4e-49196
NC_014331:57769:8966189661917602100Bacillus cereus biovar anthracis str. CI plasmid pCI-XO1, completehypothetical protein4e-49196
NC_015589:3852217:3856599385659938584431845Desulfotomaculum ruminis DSM 2154 chromosome, complete genomehypothetical protein1e-47191
NC_013131:9903320:9948989994898999507761788Catenulispora acidiphila DSM 44928, complete genometype IV secretory pathway VirB4 protein-like protein5e-47189
NC_015434:2460053:2462503246250324642061704Verrucosispora maris AB-18-032 chromosome, complete genometype iv secretory pathway virb4 protein-like protein2e-46187
NC_016582:10159486:1016391410163914101657731860Streptomyces bingchenggensis BCW-1 chromosome, complete genometype IV secretory pathway VirB4 protein-like protein3e-46187
NC_013131:7889127:7910120791012079119461827Catenulispora acidiphila DSM 44928, complete genometype IV secretory pathway VirB4 protein-like protein9e-46185
NC_014391:1910273:1908453190845319102761824Micromonospora aurantiaca ATCC 27029 chromosome, complete genometype IV secretory pathway VirB4 protein-like protein1e-44181
NC_014815:6616500:6688344668834466900951752Micromonospora sp. L5 chromosome, complete genometype iv secretory pathway virb4 protein-like protein3e-43177
NC_015603:1:4634463466522019Lactobacillus kefiranofaciens ZW3 plasmid pWW2, complete sequenceconjugal transfer protein Tra9e-43175
NC_010321:35855:5603356033578171785Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeType IV secretory pathway VirB4 components-like protein7e-42172
NC_014964:35862:5604056040578241785Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completetype IV secretory pathway VirB4 components-like protein7e-42172
NC_009921:8147947:8180935818093581829081974Frankia sp. EAN1pec, complete genomeType IV secretory pathway VirB4 protein-like protein8e-38159
NC_013849:376676:3905033905033923171815Ferroglobus placidus DSM 10642 chromosome, complete genomeType IV secretory pathway VirB4 protein-like protein6e-31136
NC_015943:47000:5749357493598862394Haloarcula hispanica ATCC 33960 chromosome chromosome II, completeType IV secretory pathway VirB4 protein-like protein2e-28127
NC_014390:1:1118811188135362349Butyrivibrio proteoclasticus B316 plasmid pCY186, completehypothetical protein1e-27125
NC_017203:73952:919649196492932969Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281,hypothetical protein1e-26122
NC_011655:88336:953709537096338969Bacillus cereus AH187 plasmid pAH187_270, complete sequencehypothetical protein8e-27122
NC_016792:143614:150648150648151616969Bacillus cereus NC7401 plasmid pNCcld, complete sequencehypothetical protein8e-27122
NC_018866:27878:4555845558478942337Dehalobacter sp. DCA chromosome, complete genomehypothetical protein2e-26120
NC_014246:57021:8641886418886402223Mobiluncus curtisii ATCC 43063 chromosome, complete genometransfer complex protein4e-25117
NC_011898:3658372:3663030366303036648621833Clostridium cellulolyticum H10, complete genomehypothetical protein3e-24114
NC_008023:1070986:1077345107734510797742430Streptococcus pyogenes MGAS2096, complete genomeTRSE protein4e-24113
NC_016791:1620858:1634019163401916358511833Clostridium sp. BNL1100 chromosome, complete genomehypothetical protein6e-24113
NC_015738:3042000:3063295306329530656042310Eggerthella sp. YY7918, complete genomehypothetical protein1e-22108
NC_015977:3424178:3501261350126135036392379Roseburia hominis A2-183 chromosome, complete genomeTRSE protein3e-22107
NC_013766:1859634:1865378186537818672101833Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein2e-22107
NC_013768:1830419:1832109183210918339411833Listeria monocytogenes 08-5923, complete genomehypothetical protein2e-22107
NC_016630:1247251:1288570128857012909632394Filifactor alocis ATCC 35896 chromosome, complete genometype IV conjugative transfer system protein TraE2e-20101
NC_019964:2816990:2844630284463028479473318Halovivax ruber XH-70, complete genomehypothetical protein3e-20100
NC_021184:3533500:3562386356238635642151830Desulfotomaculum gibsoniae DSM 7213, complete genomeprotein of unknown function DUF875e-20100
NC_012471:719000:7286357286357310642430Streptococcus equi subsp. equi 4047, complete genomeconjugal transfer protein8e-2099.4
NC_011837:3814000:3852868385286838548141947Clostridium kluyveri NBRC 12016, complete genomehypothetical protein1e-1999
NC_009706:3882500:3921365392136539231941830Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein1e-1999
NC_013316:2033906:2089315208931520917082394Clostridium difficile R20291, complete genomeputative conjugal transfer protein3e-1997.4
NC_004116:1276791:1300833130083313031632331Streptococcus agalactiae 2603V/R, complete genomeTn5252, Orf263e-1997.4
NC_012781:3315614:3349227334922733514882262Eubacterium rectale ATCC 33656, complete genomehypothetical protein5e-1996.7
NC_013164:67500:7061170611728542244Anaerococcus prevotii DSM 20548 plasmid pAPRE01, complete sequenceputative type IV secretory pathway VirB4 protein6e-1996.3
NC_018867:1357540:1374465137446513762851821Dehalobacter sp. CF chromosome, complete genomeTraE-like protein6e-1996.3
NC_009089:478328:4870544870544894472394Clostridium difficile 630, complete genomeputative conjugal transfer protein7e-1996.3
NC_016749:1371997:1394027139402713963752349Streptococcus macedonicus ACA-DC 198, complete genometrsE-like protein9e-1995.9
NC_019903:1345585:1378420137842013802491830Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,hypothetical protein1e-1895.5
NC_018866:1279000:1295925129592512976881764Dehalobacter sp. DCA chromosome, complete genomehypothetical protein1e-1895.1
NC_014624:224213:2242132242132265372325Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein2e-1894.4
NC_019903:1745849:1774508177450817763341827Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,hypothetical protein7e-1892.8
NC_004368:1386746:1413014141301414153742361Streptococcus agalactiae NEM316, complete genomehypothetical protein1e-1792.4
NC_016630:434500:4425444425444450062463Filifactor alocis ATCC 35896 chromosome, complete genometype IV conjugative transfer system protein TraE2e-1791.7
NC_004368:1160535:1181463118146311838652403Streptococcus agalactiae NEM316, complete genomehypothetical protein7e-1789.4
NC_015725:430500:4450654450654472212157Mycoplasma bovis Hubei-1 chromosome, complete genomehypothetical protein2e-1688.2
NC_018867:10238:2915829158314882331Dehalobacter sp. CF chromosome, complete genomeTrsE-like protein2e-1687.8
NC_010337:591264:6054676054676072991833Heliobacterium modesticaldum Ice1, complete genomehypothetical protein3e-1687.4
NC_018870:757416:7716197716197734511833Thermacetogenium phaeum DSM 12270 chromosome, complete genomeputative P-loop containing nucleoside triphosphate hydrolase3e-1687.4
NC_004668:2198027:2244004224400422464812478Enterococcus faecalis V583, complete genometraE protein, putative4e-1687
NC_021175:789958:8068378068378092002364Streptococcus oligofermentans AS 1.3089, complete genomehypothetical protein4e-1687
NC_012471:1197534:1259693125969312621192427Streptococcus equi subsp. equi 4047, complete genomeconjugal transfer protein5e-1583.6
NC_011898:3303381:3316322331632233181541833Clostridium cellulolyticum H10, complete genomehypothetical protein5e-1583.2
NC_006087:765081:7650817650817676062526Leifsonia xyli subsp. xyli str. CTCB07, complete genometransfer complex protein1e-1482
NC_009441:5248791:5259914525991452623732460Flavobacterium johnsoniae UW101 chromosome, complete genomeType IV secretory pathway VirB4 components-like protein2e-1481.6
NC_013967:2103968:2144614214461421463801767Haloferax volcanii DS2 chromosome, complete genometransfer complex protein homolog2e-1480.9
NC_012781:2552723:2583081258308125848381758Eubacterium rectale ATCC 33656, complete genomehypothetical protein5e-1480.1
NC_012781:700226:7139217139217156781758Eubacterium rectale ATCC 33656, complete genomehypothetical protein5e-1480.1
NC_015955:1:4498944989472142226Halophilic archaeon DL31 plasmid phalar01, complete sequencetransfer complex protein5e-1480.1
NC_010368:1:4703470369282226Halobacterium salinarum R1 plasmid PHS3, complete sequencetransfer complex protein homolog5e-1480.1
NC_016048:797762:8438798438798457081830Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein8e-1479.3
NC_014297:1037457:1047693104769310496451953Halalkalicoccus jeotgali B3 chromosome, complete genometransfer complex protein1e-1379
NC_009140:60806:8152081520839672448Salmonella enterica enterica sv Newport str. SL254, completetype IV conjugative transfer system protein TraC1e-1379
NC_010554:2646806:2689243268924326916422400Proteus mirabilis HI4320, complete genomeplasmid pilus assembly protein3e-1377.4
NC_015844:3580591:3589954358995435922932340Zobellia galactanivorans, complete genomeconjugative transposon protein TraG4e-1377
NC_013947:5747385:5765432576543257669791548Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeType IV secretory pathway VirB4 protein-like protein4e-1377
NC_009089:1283000:1306661130666113090902430Clostridium difficile 630, complete genomeputative conjugal transfer protein5e-1376.6
NC_011655:88336:915609156092531972Bacillus cereus AH187 plasmid pAH187_270, complete sequencehypothetical protein8e-1375.9
NC_011837:238160:2522582522582545222265Clostridium kluyveri NBRC 12016, complete genomehypothetical protein1e-1275.5
NC_017203:73952:957859578596765981Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281,hypothetical protein2e-1274.7
NC_009706:238160:2522582522582546212364Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein2e-1274.7
NC_013926:1009718:1014731101473110164311701Aciduliprofundum boonei T469 chromosome, complete genomeType IV secretory pathway VirB4 protein-like protein3e-1274.3
NC_019974:1115553:1120232112023211237053474Natronococcus occultus SP4, complete genomehypothetical protein5e-1273.2
NC_016776:5174606:5194576519457651970772502Bacteroides fragilis 638R, complete genomehypothetical protein7e-1272.8
NC_014332:1:5638563875721935Bacillus cereus biovar anthracis str. CI plasmid pCI-XO2, completeputative hydrolase8e-1272.8
NC_007323:81837:4733473366671935Bacillus anthracis str. 'Ames Ancestor' plasmid pXO2, completehypothetical protein8e-1272.8
NC_007323:1:4733473366671935Bacillus anthracis str. 'Ames Ancestor' plasmid pXO2, completehypothetical protein8e-1272.8
NC_006578:1:4533453364701938Bacillus thuringiensis serovar konkukian str. 97-27 plasmidpossible ATPase1e-1172.4
NC_003228:2010643:2053558205355820560592502Bacteroides fragilis NCTC 9343, complete genomeputative conserved protein found in conjugate transposon1e-1172.4
NC_013731:55627:6803168031705682538Spirosoma linguale DSM 74 plasmid pSLIN01, complete sequencehypothetical protein1e-1172
NC_012803:3691:1724717247187341488Micrococcus luteus NCTC 2665, complete genomehypothetical protein3e-1170.9
NC_013131:10322152:1035309410353094103546111518Catenulispora acidiphila DSM 44928, complete genomehypothetical protein1e-1068.6
NC_015501:1941851:1963805196380519663212517Porphyromonas asaccharolytica DSM 20707 chromosome, completeconjugation system ATPase, TraG family2e-1067.8
NC_009614:2034265:2052760205276020552942535Bacteroides vulgatus ATCC 8482 chromosome, complete genomeconjugate transposon protein4e-1067
NC_015164:1260500:1266184126618412686972514Bacteroides salanitronis DSM 18170 chromosome, complete genomeconjugation system ATPase, TraG family6e-1066.6
NC_013158:1659426:1677523167752316795141992Halorhabdus utahensis DSM 12940, complete genometransfer complex protein5e-1066.6
NC_014961:445717:4642054642054659891785Desulfurococcus mucosus DSM 2162 chromosome, complete genomeputative TrbE protein7e-1066.2
NC_016792:143614:147147147147147809663Bacillus cereus NC7401 plasmid pNCcld, complete sequencehypothetical protein8e-1066.2
NC_015177:1822000:1832448183244818349522505Pedobacter saltans DSM 12145 chromosome, complete genometype IV secretory pathway VirB4 components-like protein9e-1065.9
NC_017202:56000:667306673067614885Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT127,hypothetical protein1e-0965.9
NC_006347:1585191:1596355159635515988682514Bacteroides fragilis YCH46, complete genomeconserved protein found in conjugate transposon1e-0965.5
NC_015311:2489176:2507140250714025096532514Prevotella denticola F0289 chromosome, complete genomeTraG family conjugation system ATPase1e-0965.1
NC_016776:1609476:1621977162197716243732397Bacteroides fragilis 638R, complete genomehypothetical protein2e-0965.1
NC_015311:1827000:1847192184719218497052514Prevotella denticola F0289 chromosome, complete genomeTraG family conjugation system ATPase2e-0964.7
NC_014371:889043:8962408962408987532514Prevotella melaninogenica ATCC 25845 chromosome chromosome II,conjugation system ATPase, TraG family3e-0964.3
NC_014921:481559:4960524960524988652814Mycoplasma fermentans M64 chromosome, complete genometrse-like protein4e-0963.5
NC_014921:830334:8449848449848477972814Mycoplasma fermentans M64 chromosome, complete genometrse-like protein4e-0963.5
NC_014921:879228:8939888939888968012814Mycoplasma fermentans M64 chromosome, complete genometrse-like protein4e-0963.5
NC_014921:397771:4140454140454168582814Mycoplasma fermentans M64 chromosome, complete genometrse-like protein5e-0963.2
NC_013940:25464:3235132351355753225Deferribacter desulfuricans SSM1 megaplasmid pDF308, completehypothetical protein6e-0963.2
NC_006347:112500:1274141274141299182505Bacteroides fragilis YCH46, complete genomeTraG1e-0862.4
NC_015164:2961906:2970279297027929727832505Bacteroides salanitronis DSM 18170 chromosome, complete genomeconjugation system ATPase, TraG family1e-0862.4
NC_015277:4358000:4369849436984943723562508Sphingobacterium sp. 21 chromosome, complete genomeconjugation system ATPase, TraG family2e-0861.2
NC_011035:829945:8787078787078812832577Neisseria gonorrhoeae NCCP11945 chromosome, complete genomeprotein TraC1e-0758.9
NC_015177:1950461:1957979195797919604862508Pedobacter saltans DSM 12145 chromosome, complete genometype IV secretory pathway VirB4 components-like protein1e-0758.9
NC_006347:3199511:3207583320758332102942712Bacteroides fragilis YCH46, complete genomeconserved hypothetical protein found in conjugate transposon TraG5e-0756.6
NC_007103:230872:2354912354912380312541Bacillus cereus E33L plasmid pE33L466, complete sequencehypothetical protein1e-0655.5
NC_017201:93500:1039861039861065262541Bacillus thuringiensis serovar finitimus YBT-020 plasmid pBMB26,hypothetical protein2e-0655.1
NC_015164:493159:5319545319545346742721Bacteroides salanitronis DSM 18170 chromosome, complete genomeconjugation system ATPase, TraG family3e-0653.9