Pre_GI: BLASTP Hits

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Query: NC_017177:192933:200244 Clostridium difficile BI1, complete genome

Start: 200244, End: 203444, Length: 3201

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014628:168994:1689941689941715732580Paenibacillus polymyxa SC2 plasmid pSC2, complete sequencehypothetical protein2e-53211
NC_013315:1707293:1717093171709317189701878Clostridium difficile CD196 chromosome, complete genomephage cell wall hydrolase8e-1790.1
NC_004668:2198027:2240101224010122428782778Enterococcus faecalis V583, complete genomepeptidase, M23/M37 family4e-1687.8
NC_014828:1795781:1800331180033118016531323Ethanoligenens harbinense YUAN-3 chromosome, complete genomeNLP/P60 protein2e-1585.5
NC_016802:1615748:162052216205221621133612Corynebacterium diphtheriae HC02 chromosome, complete genomehypothetical protein3e-1584.7
NC_008529:1663000:169252816925281693286759Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365, completeCell wall-associated hydrolase9e-1480.1
NC_012781:3315614:3346278334627833490792802Eubacterium rectale ATCC 33656, complete genomepeptidase, M23 family2e-1379.3
NC_014935:31020:4481444814464841671Nitratifractor saLSUginis DSM 16511 chromosome, complete genomenlp/p60 protein6e-1377.4
NC_014727:1877764:190982719098271910609783Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,cell wall-associated hydrolase1e-1276.6
NC_008054:1649160:168352216835221684124603Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, complete1e-1276.3
NC_013192:1033177:104398910439891044534546Leptotrichia buccalis DSM 1135, complete genomeNLP/P60 protein1e-1276.3
NC_014727:1877764:190790619079061908664759Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,cell wall-associated hydrolase1e-1276.3
NC_017179:1197763:1201848120184812031221275Clostridium difficile BI1, complete genomecell wall hydrolase2e-1275.9
NC_013315:1187986:1192062119206211933451284Clostridium difficile CD196 chromosome, complete genomecell wall hydrolase2e-1275.9
NC_013316:1186156:1189678118967811909611284Clostridium difficile R20291, complete genomeputative cell wall hydrolase2e-1275.9
NC_009089:1329826:1333890133389013351851296Clostridium difficile 630, complete genomeputative cell wall hydrolase2e-1275.5
NC_008529:1663000:169444316944431695225783Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365, completeCell wall-associated hydrolase2e-1275.1
NC_008054:1649160:168437816843781685127750Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completehypothetical protein3e-1275.1
NC_004369:2203947:220829122082912208938648Corynebacterium efficiens YS-314, complete genomeputative secreted protein3e-1274.7
NC_008054:1649160:168855716885571689042486Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completehypothetical protein9e-1273.6
NC_018528:1806761:183069718306971831473777Lactobacillus helveticus R0052 chromosome, complete genomecell wall-associated hydrolase1e-1173.2
NC_011775:156673:1622511622511653973147Bacillus cereus G9842 plasmid pG9842_209, complete sequencecell wall endopeptidase, family M23/M376e-1170.9
NC_008529:1663000:169541316954131695886474Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365, complete7e-1170.5
NC_018681:5463000:547041154704115471259849Nocardia brasiliensis ATCC 700358 chromosome, complete genomehypothetical protein8e-1170.1
NC_014727:1877764:190896019089601909673714Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,cell wall-associated hydrolase8e-1170.1
NC_008054:1649160:168658316865831687056474Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completehypothetical protein8e-1170.1
NC_009617:588897:588897588897589490594Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeNLP/P60 protein1e-1069.7
NC_016582:4934854:4957079495707949584821404Streptomyces bingchenggensis BCW-1 chromosome, complete genomeNLP/P60 family secreted protein2e-1068.9
NC_011355:1:5320532063871068Mycobacterium liflandii 128FXT plasmid pMUM002, complete sequenceP60-related protein2e-1068.9
NC_005707:12735:2002220022222292208Bacillus cereus ATCC 10987 plasmid pBc10987, complete sequencepeptidase, M23/M37 family protein3e-1068.6
NC_016077:998741:100060510006051001318714Acidaminococcus intestini RyC-MR95 chromosome, complete genomehypothetical protein3e-1068.6
NC_008529:1663000:169738616973861697871486Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365, complete2e-1068.6
NC_014727:1877764:191079919107991911272474Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,cell wall-associated hydrolase4e-1067.8
NC_011777:100631:1116681116681138752208Bacillus cereus AH820 plasmid pAH820_272, complete sequencepeptidase, M23/M37 family protein5e-1067.8
NC_011655:88336:1003461003461025532208Bacillus cereus AH187 plasmid pAH187_270, complete sequencepeptidase, M23/M37 family protein5e-1067.8
NC_008054:1649160:168269716826971683476780Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completehypothetical protein8e-1067
NC_017955:1555990:1567016156701615680351020Modestobacter marinus, complete genomecell wall-associated hydrolase8e-1067
NC_015656:132633:1372181372181383691152Frankia symbiont of Datisca glomerata chromosome, complete genomeNLP/P60 protein7e-1067
NC_018528:1806761:181328018132801814212933Lactobacillus helveticus R0052 chromosome, complete genomecell wall-associated hydrolase7e-1067
NC_016792:143614:1558011558011578312031Bacillus cereus NC7401 plasmid pNCcld, complete sequencehypothetical protein7e-1067
NC_017203:73952:778987789878773876Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281,Peptidase, M23/M371e-0966.2
NC_014666:7838500:7841459784145978427001242Frankia sp. EuI1c chromosome, complete genomeNLP/P60 protein2e-0965.9
NC_021182:2013500:2029484202948420306831200Clostridium pasteurianum BC1, complete genomecell wall-associated hydrolase, invasion-associated protein2e-0965.9
NC_014550:615609:624535624535625362828Arthrobacter arilaitensis Re117, complete genomehypothetical protein2e-0965.9
NC_014210:3742112:3761352376135237623561005Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 chromosome,NLP/P60 protein4e-0964.7
NC_015687:303810:3613653613653625431179Clostridium acetobutylicum DSM 1731 chromosome, complete genomecell wall-associated hydrolase4e-0964.7
NC_003030:303812:3613693613693625471179Clostridium acetobutylicum ATCC 824, complete genomeCell wall-associated hydrolase4e-0964.7
NC_014727:1877764:190708119070811907860780Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,cell wall-associated hydrolase4e-0964.7
NC_012473:46000:8280082800850042205Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequencepeptidase, M23/M37 family protein3e-0964.7
NC_008529:1663000:169170316917031692482780Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365, completeCell wall-associated hydrolase3e-0964.7
NC_014393:187454:2164722164722182801809Clostridium cellulovorans 743B chromosome, complete genomeNLP/P60 protein4e-0964.3
NC_009077:4774499:4795469479546947965601092Mycobacterium sp. JLS, complete genomeNLP/P60 protein6e-0963.9
NC_009077:4747922:4753114475311447542261113Mycobacterium sp. JLS, complete genomeNLP/P60 protein6e-0963.9
NC_012656:67949:9624696246979761731Bacillus anthracis str. A0248 plasmid pXO1, complete sequence6e-0963.9
NC_016802:1615748:1619339161933916203821044Corynebacterium diphtheriae HC02 chromosome, complete genomeputative secreted protein1e-0862.8
NC_014814:5422972:5453657545365754547451089Mycobacterium sp. Spyr1 chromosome, complete genomecell wall-associated hydrolase, invasion-associated protein1e-0862.8
NC_008146:1535827:1561865156186515629501086Mycobacterium sp. MCS, complete genomeNLP/P602e-0862.8
NC_008705:1557711:1566173156617315672581086Mycobacterium sp. KMS, complete genomeNLP/P60 protein2e-0862.8
NC_012803:691215:725910725910726788879Micrococcus luteus NCTC 2665, complete genomecell wall-associated hydrolase, invasion-associated protein2e-0862.4
NC_003155:4906639:4928935492893549300261092Streptomyces avermitilis MA-4680, complete genomeNLP/P60-family secreted protein3e-0862
NC_017201:93500:99273992731004841212Bacillus thuringiensis serovar finitimus YBT-020 plasmid pBMB26,hypothetical protein3e-0862
NC_013171:1194500:1215503121550312171731671Anaerococcus prevotii DSM 20548, complete genomeNLP/P60 protein3e-0862
NC_013131:9903320:9932505993250599336261122Catenulispora acidiphila DSM 44928, complete genomeNLP/P60 protein3e-0861.6
NC_009338:2925286:2965155296515529662011047Mycobacterium gilvum PYR-GCK chromosome, complete genomeNLP/P60 protein3e-0861.6
NC_008726:3947917:3947917394791739489631047Mycobacterium vanbaalenii PYR-1, complete genomeNLP/P60 protein3e-0861.6
NC_016584:3645245:364620336462033646874672Desulfosporosinus orientis DSM 765 chromosome, complete genomecell wall-associated hydrolase3e-0861.6
NC_004369:2203947:220709322070932208013921Corynebacterium efficiens YS-314, complete genomeputative secreted protein4e-0861.2
NC_013159:1225866:123407212340721234602531Saccharomonospora viridis DSM 43017, complete genomecell wall-associated hydrolase, invasion-associated protein4e-0861.2
NC_009339:274428:2794212794212806831263Mycobacterium gilvum PYR-GCK plasmid pMFLV01, complete sequenceNLP/P60 protein5e-0861.2
NC_014165:3559305:3577571357757135787161146Thermobispora bispora DSM 43833 chromosome, complete genomeNLP/P60 protein5e-0860.8
NC_007333:2674596:268662226866222687290669Thermobifida fusca YX, complete genomesimilar to Cell wall-associated hydrolase (invasion-associated proteins)5e-0860.8
NC_014151:657382:6602626602626617701509Cellulomonas flavigena DSM 20109 chromosome, complete genomeNLP/P60 protein7e-0860.5
NC_009338:912894:9319159319159330061092Mycobacterium gilvum PYR-GCK chromosome, complete genomeNLP/P60 protein7e-0860.5
NC_007333:537292:5463515463515475231173Thermobifida fusca YX, complete genomesimilar to Cell wall-associated hydrolase (invasion-associated proteins)1e-0760.1
NC_014376:3214222:3216960321696032180031044Clostridium saccharolyticum WM1 chromosome, complete genomeNLP/P60 protein2e-0759.3
NC_013204:2371499:2401442240144224035322091Eggerthella lenta DSM 2243, complete genomeNLP/P60 protein2e-0758.9
NC_012654:92487:9248792487935151029Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequencecell wall-associated hydrolase2e-0758.9
NC_009483:1116385:1129587112958711308881302Geobacter uraniireducens Rf4 chromosome, complete genomepeptidase M23B2e-0758.9
NC_014329:1169674:1169674116967411714611788Corynebacterium pseudotuberculosis FRC41 chromosome, completeresuscitation-promoting factor interacting protein2e-0758.9
NC_016781:1169632:1169632116963211714191788Corynebacterium pseudotuberculosis 3/99-5 chromosome, completeinvasion-associated protein p602e-0758.9
NC_014172:100718:1135971135971148081212Bacillus thuringiensis BMB171 plasmid pBMB171, complete sequencelipoprotein NLP/P603e-0758.5
NC_016801:1255611:1307099130709913088171719Corynebacterium diphtheriae C7 (beta) chromosome, complete genomecell wall-associated hydrolase resuscitation promoting factor interacting protein3e-0758.5
NC_016783:1274000:1286265128626512879831719Corynebacterium diphtheriae INCA 402 chromosome, complete genomecell wall-associated hydrolase resuscitation promoting factor interacting protein2e-0758.5
NC_016788:1214026:1261377126137712630951719Corynebacterium diphtheriae HC04 chromosome, complete genomecell wall-associated hydrolase resuscitation promoting factor interacting protein2e-0758.5
NC_010572:6293417:6315441631544163164661026Streptomyces griseus subsp. griseus NBRC 13350, complete genomeputative NLP/P60-family secreted protein2e-0758.5
NC_010674:1986000:1994797199479719962541458Clostridium botulinum B str. Eklund 17B, complete genomeNlpC/P60 family protein3e-0758.2
NC_016782:1251796:1261966126196612636841719Corynebacterium diphtheriae 241 chromosome, complete genomecell wall-associated hydrolase resuscitation promoting factor interacting protein3e-0758.2
NC_016786:1251765:1261935126193512636531719Corynebacterium diphtheriae HC01 chromosome, complete genomecell wall-associated hydrolase resuscitation promoting factor interacting protein3e-0758.2
NC_016789:1295918:1306088130608813078061719Corynebacterium diphtheriae PW8 chromosome, complete genomecell wall-associated hydrolase resuscitation promoting factor interacting protein3e-0758.2
NC_016799:1268706:1317422131742213191401719Corynebacterium diphtheriae 31A chromosome, complete genomecell wall-associated hydrolase resuscitation promoting factor interacting protein3e-0758.2
NC_016800:1243000:1290538129053812922561719Corynebacterium diphtheriae BH8 chromosome, complete genomecell wall-associated hydrolase resuscitation promoting factor interacting protein3e-0758.2
NC_016802:1256287:1262872126287212645901719Corynebacterium diphtheriae HC02 chromosome, complete genomecell wall-associated hydrolase resuscitation promoting factor interacting protein3e-0758.2
NC_002935:1237585:1288281128828112899991719Corynebacterium diphtheriae NCTC 13129, complete genomePutative invasion protein3e-0758.2
NC_016790:1218596:1228766122876612304841719Corynebacterium diphtheriae VA01 chromosome, complete genomecell wall-associated hydrolase resuscitation promoting factor interacting protein3e-0758.2
NC_016785:1233384:1243554124355412452721719Corynebacterium diphtheriae CDCE 8392 chromosome, complete genomecell wall-associated hydrolase resuscitation promoting factor interacting protein3e-0758.2
NC_016787:1240000:1251388125138812531061719Corynebacterium diphtheriae HC03 chromosome, complete genomecell wall-associated hydrolase resuscitation promoting factor interacting protein3e-0758.2
NC_007103:230872:2410172410172422281212Bacillus cereus E33L plasmid pE33L466, complete sequencehypothetical protein4e-0757.8
NC_016630:434500:4407164407164425571842Filifactor alocis ATCC 35896 chromosome, complete genomepeptidase, M23/M37 family5e-0757.8
NC_013947:6221877:6239631623963162406321002Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeNLP/P60 protein9e-0757
NC_016779:4864056:4895955489595548972951341Bacillus cereus F837/76 chromosome, complete genomeN-acetylmuramoyl-L-alanine amidase9e-0756.6
NC_008600:4898000:4930956493095649322661311Bacillus thuringiensis str. Al Hakam, complete genomeendopeptidase lytE, NLP/P60 family fusion protein9e-0756.6
NC_012472:4908245:4941222494122249425321311Bacillus cereus 03BB102, complete genomeputative cell wall endopeptidase, NlpC/P60 family9e-0756.6
NC_013891:353625:371219371219371902684Listeria seeligeri serovar 1/2b str. SLCC3954, complete genomeNLP/P60 family protein9e-0756.6
NC_014136:329484:3398763398763455095634Leuconostoc kimchii IMSNU11154 chromosome, complete genomeprophage pi3 protein 141e-0656.6
NC_018866:1279000:1294669129466912957421074Dehalobacter sp. DCA chromosome, complete genomeMembrane protein related to metalloendopeptidase1e-0656.6
NC_018867:1357540:1373209137320913742821074Dehalobacter sp. CF chromosome, complete genomeMembrane protein related to metalloendopeptidase1e-0656.6
NC_011725:5075285:5109294510929451107151422Bacillus cereus B4264 chromosome, complete genomecell wall endopeptidase, NlpC/P60 family1e-0656.2
NC_017208:5143500:5158897515889751603241428Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeN-acetylmuramoyl-L-alanine amidase2e-0655.8
NC_011775:156673:1600471600471614231377Bacillus cereus G9842 plasmid pG9842_209, complete sequenceNlpC/P60 family protein2e-0655.8
NC_015953:4045500:4064420406442040654841065Streptomyces sp. SirexAA-E chromosome, complete genomeNLP/P60 protein2e-0655.8
NC_013947:613774:6174056174056187031299Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeNLP/P60 protein2e-0655.8
NC_006087:2214209:2214764221476422159661203Leifsonia xyli subsp. xyli str. CTCB07, complete genomepeptidoglycan lytic protein P452e-0655.8
NC_009664:533021:5479845479845490901107Kineococcus radiotolerans SRS30216, complete genomeLytic transglycosylase catalytic2e-0655.5
NC_017202:56000:6200862008630451038Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT127,hypothetical protein3e-0655.1
NC_018524:3075000:3078559307855930797311173Nocardiopsis alba ATCC BAA-2165 chromosome, complete genometransglycosylase SLT domain protein3e-0655.1
NC_018870:757416:7750847750847761691086Thermacetogenium phaeum DSM 12270 chromosome, complete genomemetalloprotease YebA3e-0655.1
NC_014538:2158131:2170232217023221718571626Thermoanaerobacter sp. X513 chromosome, complete genomePeptidase M236e-0654.3
NC_011898:3303381:3310855331085533119911137Clostridium cellulolyticum H10, complete genomeNLP/P60 protein7e-0653.9
NC_000964:2146000:2248350224835022552076858Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein8e-0653.5
NC_012673:1:3354033540353871848Exiguobacterium sp. AT1b, complete genomeNLP/P60 protein9e-0653.5
NC_012984:1027898:1048157104815710533075151Lactobacillus plantarum JDM1, complete genomeSLT domain protein1e-0553.5