Pre_GI: BLASTP Hits

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Query: NC_017177:175000:192933 Clostridium difficile BI1, complete genome

Start: 192933, End: 194753, Length: 1821

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017177:192933:1929331929331947531821Clostridium difficile BI1, complete genomehypothetical protein01210
NC_011004:4183993:4209018420901842107631746Rhodopseudomonas palustris TIE-1, complete genomeprotein of unknown function DUF876e-1686.3
NC_019792:2524130:2555390255539025570331644Natronobacterium gregoryi SP2 chromosome, complete genomeATPase2e-1584.3
NC_014537:603564:6071166071166090381923Vulcanisaeta distributa DSM 14429 chromosome, complete genomehypothetical protein3e-1480.9
NC_015151:1427965:1431000143100014329221923Vulcanisaeta moutnovskia 768-28 chromosome, complete genomeATPase2e-1378.2
NC_015320:1342105:1380643138064313822201578Archaeoglobus veneficus SNP6 chromosome, complete genomehypothetical protein7e-1376.3
NC_015931:1443447:1452914145291414544131500Pyrolobus fumarii 1A, complete genomeHerA-ATP synthase with barrel domain6e-1376.3
NC_013665:918313:9209109209109224391530Methanocella paludicola SANAE, complete genomehypothetical protein4e-1273.6
NC_015216:2113556:2124209212420921257441536Methanobacterium sp. AL-21 chromosome, complete genomehypothetical protein5e-1273.2
NC_011831:1693935:1699397169939717010131617Chloroflexus aggregans DSM 9485, complete genomeprotein of unknown function DUF879e-1272.4
NC_016885:1153277:1154428115442811562781851Pyrobaculum oguniense TE7 chromosome, complete genomeputative ATPase2e-1171.6
NC_014160:748743:7835657835657851061542Thermosphaera aggregans DSM 11486 chromosome, complete genomehypothetical protein4e-1170.5
NC_014122:726070:7362547362547378971644Methanocaldococcus infernus ME chromosome, complete genomeprotein of unknown function DUF874e-1170.5
NC_015680:1315040:1337033133703313389491917Pyrococcus yayanosii CH1 chromosome, complete genomehypothetical protein4e-1170.1
NC_016024:1099602:1108817110881711106191803Candidatus Chloracidobacterium thermophilum B chromosome chromosomeputative ATPase7e-1169.3
NC_009901:2272206:2279689227968922813411653Shewanella pealeana ATCC 700345, complete genomeprotein of unknown function DUF871e-1068.9
NC_019791:570923:5872775872775888151539Caldisphaera lagunensis DSM 15908 chromosome, complete genomeATPase2e-1068.6
NC_000961:828416:8419908419908436571668Pyrococcus horikoshii OT3, complete genomehypothetical protein6e-1066.2
NC_011770:2499432:2534701253470125363861686Pseudomonas aeruginosa LESB58, complete genomeprotein of unknown function DUF879e-1065.9
NC_000868:1168819:1173575117357511752211647Pyrococcus abyssi GE5, complete genomehypothetical protein8e-1065.9
NC_015635:4097711:4127390412739041291381749Microlunatus phosphovorus NM-1, complete genomehypothetical protein1e-0965.1
NC_013205:1275012:1290516129051612922431728Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,protein of unknown function DUF871e-0965.1
NC_021184:1484352:1506874150687415086191746Desulfotomaculum gibsoniae DSM 7213, complete genomeputative ATPase2e-0965.1
NC_015565:287900:3092013092013108861686Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completehypothetical protein2e-0964.7
NC_015474:1490668:1507956150795615095961641Pyrococcus sp. NA2 chromosome, complete genomehypothetical protein2e-0964.3
NC_014972:137184:1478981478981497901893Desulfobulbus propionicus DSM 2032 chromosome, complete genomehypothetical protein3e-0963.9
NC_008639:1462000:1471367147136714731661800Chlorobium phaeobacteroides DSM 266, complete genomeprotein of unknown function DUF873e-0963.9
NC_012997:817553:8307608307608326011842Teredinibacter turnerae T7901, complete genomehypothetical protein3e-0963.9
NC_018867:993903:1001287100128710030621776Dehalobacter sp. CF chromosome, complete genomeprotein of unknown function DUF873e-0963.9
NC_018866:925704:9366669366669384411776Dehalobacter sp. DCA chromosome, complete genomeBipolar DNA helicase3e-0963.9
NC_003413:1107965:1111866111186611135211656Pyrococcus furiosus DSM 3638, complete genomehypothetical protein1e-0862
NC_002947:4994335:5042929504292950446921764Pseudomonas putida KT2440, complete genomehypothetical protein2e-0860.8
NC_015160:2145915:2159124215912421612142091Odoribacter splanchnicus DSM 20712 chromosome, complete genomehypothetical protein3e-0860.8
NC_011663:2813033:2822047282204728238251779Shewanella baltica OS223 chromosome, complete genomehypothetical protein4e-0860.5
NC_009050:212270:2400382400382420171980Rhodobacter sphaeroides ATCC 17029 chromosome 2, complete sequenceATPase-like protein7e-0859.3
NC_008577:2402165:2428148242814824299171770Shewanella sp. ANA-3 chromosome 1, complete sequencehypothetical protein2e-0758.2
NC_011071:1877500:1884907188490718866821776Stenotrophomonas maltophilia R551-3, complete genomeprotein of unknown function DUF873e-0757.4
NC_007005:98488:1094521094521113231872Pseudomonas syringae pv. syringae B728a, complete genomeProtein of unknown function DUF874e-0757
NC_013960:1484824:1498881149888115022043324Nitrosococcus halophilus Nc4 chromosome, complete genomeATPase-like protein5e-0756.6
NC_015573:569625:6010336010336032402208Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomehypothetical protein5e-0756.6
NC_009441:4357593:4378411437841143801951785Flavobacterium johnsoniae UW101 chromosome, complete genomehypothetical protein5e-0756.6
NC_013406:7024149:7052006705200670537961791Paenibacillus sp. Y412MC10 chromosome, complete genomehypothetical protein8e-0755.8
NC_015519:2413323:2416193241619324178781686Tepidanaerobacter sp. Re1 chromosome, complete genomehypothetical protein1e-0655.5
NC_020409:2222000:2232477223247722343481872Desulfovibrio piezophilus str. nov C1TLV30 chromosome, completehypothetical protein1e-0655.5
NC_009050:212270:2580402580402597791740Rhodobacter sphaeroides ATCC 17029 chromosome 2, complete sequencehypothetical protein2e-0655.1
NC_014311:1106871:1114757111475711164541698Ralstonia solanacearum PSI07 chromosome, complete genomehypothetical protein3e-0654.3
NC_020829:2152000:2161000216100021629041905Pseudomonas denitrificans ATCC 13867, complete genomeATPase6e-0653.1
NC_015676:2099930:2117908211790821197131806Methanosalsum zhilinae DSM 4017 chromosome, complete genomeATPase8e-0652.8