Pre_GI: BLASTP Hits

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Query: NC_017177:175000:179545 Clostridium difficile BI1, complete genome

Start: 179545, End: 180591, Length: 1047

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017177:91993:1047141047141057301017Clostridium difficile BI1, complete genomehypothetical protein2e-60233
NC_017177:91993:1083451083451093671023Clostridium difficile BI1, complete genomehypothetical protein6e-59228
NC_017177:91993:111492111492112439948Clostridium difficile BI1, complete genomehypothetical protein8e-59227
NC_017177:175000:1817061817061832891584Clostridium difficile BI1, complete genomehypothetical protein2e-57223
NC_017177:136082:138056138056138880825Clostridium difficile BI1, complete genomehypothetical protein3e-52205
NC_017177:136082:1456741456741477492076Clostridium difficile BI1, complete genomehypothetical protein1e-50200
NC_017177:91993:1021481021481044662319Clostridium difficile BI1, complete genomehypothetical protein3e-47189
NC_017177:91993:121784121784122584801Clostridium difficile BI1, complete genomehypothetical protein2e-42173
NC_017177:91993:977499774998573825Clostridium difficile BI1, complete genomehypothetical protein8e-40164
NC_017177:175000:1866711866711876751005Clostridium difficile BI1, complete genomehypothetical protein1e-38160
NC_013316:891782:9087929087929098021011Clostridium difficile R20291, complete genomehypothetical protein5e-37155
NC_013315:895500:9111779111779121871011Clostridium difficile CD196 chromosome, complete genomehypothetical protein5e-37155
NC_017179:905347:9209549209549219641011Clostridium difficile BI1, complete genomehypothetical protein5e-37155
NC_009089:965959:9815669815669825761011Clostridium difficile 630, complete genomehypothetical protein7e-37154
NC_017177:136082:152286152286152945660Clostridium difficile BI1, complete genomehypothetical protein7e-34144
NC_017177:136082:139285139285140004720Clostridium difficile BI1, complete genomehypothetical protein2e-32140
NC_017177:136082:140392140392140997606Clostridium difficile BI1, complete genomehypothetical protein3e-31136
NC_017177:175000:180704180704181534831Clostridium difficile BI1, complete genomehypothetical protein6e-29128
NC_017177:175000:177542177542178420879Clostridium difficile BI1, complete genomehypothetical protein1e-28127
NC_017177:91993:100796100796101341546Clostridium difficile BI1, complete genomehypothetical protein2e-26120
NC_017177:91993:991579915799837681Clostridium difficile BI1, complete genomehypothetical protein1e-26120
NC_017177:91993:112814112814113497684Clostridium difficile BI1, complete genomehypothetical protein1e-23110
NC_017177:91993:124467124467124907441Clostridium difficile BI1, complete genomehypothetical protein5e-22105
NC_017177:91993:120684120684121265582Clostridium difficile BI1, complete genomehypothetical protein1e-20101
NC_017177:91993:100130100130100612483Clostridium difficile BI1, complete genomehypothetical protein4e-2099.4
NC_017177:175000:175873175873176235363Clostridium difficile BI1, complete genomehypothetical protein1e-1997.8
NC_017177:175000:183584183584184042459Clostridium difficile BI1, complete genomehypothetical protein2e-1996.7
NC_017177:91993:945479454795110564Clostridium difficile BI1, complete genomehypothetical protein4e-1789
NC_015578:2341026:2366628236662823696092982Treponema primitia ZAS-2 chromosome, complete genomehypothetical protein7e-1788.6
NC_017177:175000:178802178802179362561Clostridium difficile BI1, complete genomehypothetical protein1e-1584.3
NC_017177:91993:967139671397126414Clostridium difficile BI1, complete genomehypothetical protein9e-1581.3
NC_017177:91993:123205123205123693489Clostridium difficile BI1, complete genomehypothetical protein2e-1376.6
NC_015578:2341026:2350601235060123536843084Treponema primitia ZAS-2 chromosome, complete genomehypothetical protein1e-1274.3
NC_015578:2341026:2355045235504523581283084Treponema primitia ZAS-2 chromosome, complete genomehypothetical protein6e-1272
NC_017177:175000:176240176240176494255Clostridium difficile BI1, complete genomehypothetical protein2e-1170.1
NC_011830:2177187:220330322033032204103801Desulfitobacterium hafniense DCB-2, complete genomehypothetical protein3e-1066.6
NC_015761:1970042:1980567198056719824561890Salmonella bongori NCTC 12419, complete genomevirulence protein4e-0962.4
NC_014638:363577:3806973806973835072811Bifidobacterium bifidum PRL2010 chromosome, complete genomehypothetical protein9e-0961.6
NC_017177:91993:124092124092124439348Clostridium difficile BI1, complete genomehypothetical protein3e-0653.1
NC_017177:175000:178581178581178799219Clostridium difficile BI1, complete genomehypothetical protein4e-0652.4