Pre_GI: BLASTP Hits

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Query: NC_017177:175000:178581 Clostridium difficile BI1, complete genome

Start: 178581, End: 178799, Length: 219

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017177:91993:1021481021481044662319Clostridium difficile BI1, complete genomehypothetical protein1e-1271.6
NC_017177:91993:111492111492112439948Clostridium difficile BI1, complete genomehypothetical protein1e-1168.2
NC_017179:905347:9209549209549219641011Clostridium difficile BI1, complete genomehypothetical protein3e-1167.4
NC_013315:895500:9111779111779121871011Clostridium difficile CD196 chromosome, complete genomehypothetical protein3e-1167.4
NC_013316:891782:9087929087929098021011Clostridium difficile R20291, complete genomehypothetical protein3e-1167.4
NC_017177:175000:175873175873176235363Clostridium difficile BI1, complete genomehypothetical protein3e-1167.4
NC_009089:965959:9815669815669825761011Clostridium difficile 630, complete genomehypothetical protein3e-1167.4
NC_017177:91993:124467124467124907441Clostridium difficile BI1, complete genomehypothetical protein5e-1166.6
NC_017177:136082:138056138056138880825Clostridium difficile BI1, complete genomehypothetical protein4e-1166.6
NC_017177:136082:152286152286152945660Clostridium difficile BI1, complete genomehypothetical protein5e-1166.2
NC_017177:136082:1456741456741477492076Clostridium difficile BI1, complete genomehypothetical protein7e-1165.9
NC_017177:91993:1083451083451093671023Clostridium difficile BI1, complete genomehypothetical protein2e-1064.7
NC_017177:91993:100130100130100612483Clostridium difficile BI1, complete genomehypothetical protein2e-1064.7
NC_017177:175000:183584183584184042459Clostridium difficile BI1, complete genomehypothetical protein2e-1064.3
NC_017177:91993:977499774998573825Clostridium difficile BI1, complete genomehypothetical protein4e-1063.5
NC_017177:175000:1817061817061832891584Clostridium difficile BI1, complete genomehypothetical protein7e-1062.8
NC_017177:91993:1047141047141057301017Clostridium difficile BI1, complete genomehypothetical protein2e-0961.2
NC_017177:136082:139285139285140004720Clostridium difficile BI1, complete genomehypothetical protein3e-0960.5
NC_017177:91993:121784121784122584801Clostridium difficile BI1, complete genomehypothetical protein1e-0858.5
NC_017177:91993:112814112814113497684Clostridium difficile BI1, complete genomehypothetical protein2e-0857.8
NC_017177:91993:991579915799837681Clostridium difficile BI1, complete genomehypothetical protein3e-0857
NC_017177:175000:177542177542178420879Clostridium difficile BI1, complete genomehypothetical protein3e-0857
NC_017177:175000:176240176240176494255Clostridium difficile BI1, complete genomehypothetical protein4e-0856.6
NC_017177:91993:100796100796101341546Clostridium difficile BI1, complete genomehypothetical protein4e-0856.6
NC_017177:175000:1866711866711876751005Clostridium difficile BI1, complete genomehypothetical protein7e-0856.2
NC_017177:136082:140392140392140997606Clostridium difficile BI1, complete genomehypothetical protein4e-0753.5
NC_017177:175000:1795451795451805911047Clostridium difficile BI1, complete genomehypothetical protein8e-0752.4
NC_017177:91993:967139671397126414Clostridium difficile BI1, complete genomehypothetical protein8e-0752.4
NC_017177:91993:945479454795110564Clostridium difficile BI1, complete genomehypothetical protein2e-0651.6
NC_017177:91993:123205123205123693489Clostridium difficile BI1, complete genomehypothetical protein8e-0649.3