Pre_GI: BLASTP Hits

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Query: NC_017177:136082:143244 Clostridium difficile BI1, complete genome

Start: 143244, End: 143444, Length: 201

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017177:91993:111492111492112439948Clostridium difficile BI1, complete genomehypothetical protein5e-2199.8
NC_017177:136082:140392140392140997606Clostridium difficile BI1, complete genomehypothetical protein1e-1995.1
NC_017177:91993:1047141047141057301017Clostridium difficile BI1, complete genomehypothetical protein2e-1994
NC_017177:91993:1083451083451093671023Clostridium difficile BI1, complete genomehypothetical protein1e-1891.7
NC_017177:91993:121784121784122584801Clostridium difficile BI1, complete genomehypothetical protein4e-1889.7
NC_017177:91993:124092124092124439348Clostridium difficile BI1, complete genomehypothetical protein6e-1889.4
NC_017177:136082:139285139285140004720Clostridium difficile BI1, complete genomehypothetical protein3e-1683.6
NC_017177:175000:1866711866711876751005Clostridium difficile BI1, complete genomehypothetical protein1e-1581.6
NC_017177:175000:180704180704181534831Clostridium difficile BI1, complete genomehypothetical protein9e-1579
NC_017177:91993:100796100796101341546Clostridium difficile BI1, complete genomehypothetical protein2e-1477.4
NC_017177:175000:1817061817061832891584Clostridium difficile BI1, complete genomehypothetical protein2e-1374.7
NC_017177:136082:138056138056138880825Clostridium difficile BI1, complete genomehypothetical protein2e-1374.3
NC_017177:91993:120684120684121265582Clostridium difficile BI1, complete genomehypothetical protein2e-1168.2
NC_017177:91993:967139671397126414Clostridium difficile BI1, complete genomehypothetical protein6e-0752.8