Pre_GI: BLASTP Hits

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Query: NC_017168:561402:582257 Yersinia pestis A1122 chromosome, complete genome

Start: 582257, End: 582721, Length: 465

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010159:770172:791020791020791484465Yersinia pestis Angola, complete genomehypothetical protein5e-81299
NC_004088:4073698:409700540970054097469465Yersinia pestis KIM, complete genomehypothetical protein5e-81299
NC_010465:3919572:394044639404463940910465Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein3e-78290
NC_009708:3862044:388537038853703885834465Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein2e-75280