Pre_GI: BLASTP Hits

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Query: NC_017168:4363000:4383811 Yersinia pestis A1122 chromosome, complete genome

Start: 4383811, End: 4384299, Length: 489

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017154:1454704:147523714752371475725489Yersinia pestis D106004 chromosome, complete genomehypothetical protein3e-89327
NC_006155:1567306:158783915878391588327489Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein3e-89327
NC_003143:1441211:146174314617431462231489Yersinia pestis CO92, complete genomehypothetical protein3e-89327
NC_010634:1565788:158633615863361586824489Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein4e-89326
NC_014029:1512605:153316815331681533617450Yersinia pestis Z176003 chromosome, complete genomehypothetical protein7e-82302