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Query: NC_017168:3977767:4016349 Yersinia pestis A1122 chromosome, complete genome

Start: 4016349, End: 4017530, Length: 1182

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017160:1628500:1633561163356116347121152Yersinia pestis D182038 chromosome, complete genomehypothetical protein0764
NC_017154:1644404:1653066165306616542171152Yersinia pestis D106004 chromosome, complete genomehypothetical protein0764
NC_014029:1702338:1710999171099917121501152Yersinia pestis Z176003 chromosome, complete genomehypothetical protein0764
NC_008150:844727:853559853559854539981Yersinia pestis Antiqua, complete genomehypothetical protein0646
NC_008149:2802392:284105628410562842036981Yersinia pestis Nepal516, complete genomehypothetical protein0646
NC_007946:4779745:4817383481738348204273045Escherichia coli UTI89, complete genomecytotoxic necrotizing factor 12e-132472
NC_010159:3120642:312466531246653124808144Yersinia pestis Angola, complete genome1e-1997.8
NC_012214:897206:9069669069669101903225Erwinia pyrifoliae Ep1/96, complete genomeProbable cytotoxic necrotizing factor type 21e-0654.7
NC_010694:891967:9017209017209049413222Erwinia tasmaniensis, complete genomeProbable cytotoxic necrotizing factor type 22e-0654.3