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Query: NC_017168:2626996:2638447 Yersinia pestis A1122 chromosome, complete genome

Start: 2638447, End: 2638698, Length: 252

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004088:1265730:127718112771811277432252Yersinia pestis KIM, complete genomehypothetical protein1e-41167
NC_005810:1230976:123696112369611237212252Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein1e-41167
NC_008150:2822689:282999828299982830249252Yersinia pestis Antiqua, complete genomehypothetical protein1e-41167
NC_008149:1195614:120706512070651207316252Yersinia pestis Nepal516, complete genomehypothetical protein1e-41167
NC_003143:3115933:312372631237263123977252Yersinia pestis CO92, complete genomehypothetical protein1e-41167