Pre_GI: BLASTP Hits

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Query: NC_017160:643406:666025 Yersinia pestis D182038 chromosome, complete genome

Start: 666025, End: 669270, Length: 3246

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009381:427515:4500264500264533793354Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein02211
NC_020291:6310000:6318106631810663214743369Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomecellobiose phosphorylase0736
NC_013521:713196:7292647292647327013438Sanguibacter keddieii DSM 10542, complete genomecellobiose phosphorylase8e-154545