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Query: NC_017154:2901300:2902327 Yersinia pestis D106004 chromosome, complete genome

Start: 2902327, End: 2902797, Length: 471

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:2560000:256228725622872563036750Yersinia pestis A1122 chromosome, complete genometype IV pilus biogenesis/stability protein PilW1e-80298
NC_008150:2599661:260068826006882601437750Yersinia pestis Antiqua, complete genomeputative fimbrial biogenesis protein1e-80298
NC_010159:409500:435812435812436561750Yersinia pestis Angola, complete genometype IV pilus biogenesis/stability protein PilW1e-80298
NC_010634:3269010:327627932762793277028750Yersinia pseudotuberculosis PB1/+, complete genometype IV pilus biogenesis/stability protein PilW6e-80295
NC_015222:1127675:113577411357741136553780Nitrosomonas sp. AL212 chromosome, complete genometype IV pilus biogenesis/stability protein PilW9e-0752.8