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Query: NC_017154:2306421:2313370 Yersinia pestis D106004 chromosome, complete genome

Start: 2313370, End: 2313723, Length: 354

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003143:2309500:2316429231642923181021674Yersinia pestis CO92, complete genomeputative hemolysin activator protein1e-63241
NC_010159:2546590:2556799255679925584601662Yersinia pestis Angola, complete genomehaemolysin secretion/activation protein, ShlB/FhaC/HecB family2e-63240
NC_005810:2091930:2098839209883921005001662Yersinia pestis biovar Microtus str. 91001, complete genomeputative hemolysin activator protein2e-63240
NC_008150:1593500:1600745160074516024061662Yersinia pestis Antiqua, complete genomeputative hemolysin activator protein2e-63240
NC_008149:1718000:1725065172506517267261662Yersinia pestis Nepal516, complete genomehemolysin activator protein2e-63240
NC_009381:1205900:1215955121595512176161662Yersinia pestis Pestoides F chromosome, complete genomehemolysin activator protein2e-63240
NC_014029:2285323:2295406229540622970671662Yersinia pestis Z176003 chromosome, complete genomeputative hemolysin activator protein2e-63240
NC_017160:2212806:2222905222290522245661662Yersinia pestis D182038 chromosome, complete genomeputative hemolysin activator protein2e-63240
NC_017168:3433804:3443879344387934455401662Yersinia pestis A1122 chromosome, complete genomeputative hemolysin activator protein2e-63240
NC_017265:2213500:2223081222308122247421662Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,putative hemolysin activator protein2e-63240
NC_010465:2383219:2393293239329323949541662Yersinia pseudotuberculosis YPIII, complete genomeHemolysin activator HlyB domain protein2e-60230
NC_004088:2491303:2501386250138625030201635Yersinia pestis KIM, complete genomehemolysin activator protein1e-57221
NC_010634:2297000:2303373230337323050341662Yersinia pseudotuberculosis PB1/+, complete genomehemolysin activator HlyB domain-containing protein1e-39161
NC_006155:2378526:2385477238547723871381662Yersinia pseudotuberculosis IP 32953, complete genomehemolysin activator protein HlyB, TPS secretion family2e-39160
NC_009708:2347350:2356255235625523577961542Yersinia pseudotuberculosis IP 31758 chromosome, complete genomeShlB/FhaC/HecB family hemolysin secretion/activation protein2e-25114
NC_008800:2592500:2600399260039926020661668Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,putative hemolysin activator protein6e-1682.8
NC_012779:957558:9765099765099781881680Edwardsiella ictaluri 93-146, complete genomehemolysin activator protein3e-0650.8