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Query: NC_017154:1644404:1652410 Yersinia pestis D106004 chromosome, complete genome

Start: 1652410, End: 1652766, Length: 357

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008149:2802392:284250728425072842869363Yersinia pestis Nepal516, complete genomehypothetical protein3e-65246
NC_008150:844727:852726852726853088363Yersinia pestis Antiqua, complete genomehypothetical protein3e-65246
NC_017160:1628500:163290516329051633261357Yersinia pestis D182038 chromosome, complete genomehypothetical protein3e-65246
NC_014029:1702338:171034317103431710699357Yersinia pestis Z176003 chromosome, complete genomehypothetical protein3e-65246
NC_007946:4779745:4817383481738348204273045Escherichia coli UTI89, complete genomecytotoxic necrotizing factor 15e-46182