Pre_GI: BLASTP Hits

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Query: NC_017066:312000:328772 Rickettsia typhi str. TH1527 chromosome, complete genome

Start: 328772, End: 329230, Length: 459

Host Lineage: Rickettsia typhi; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. R. prowazekii, and genomic comparisons demonstrate colinearity and similarity to the genome of that organism except for two independent inversions near the origin and terminus. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_006142:312000:328758328758329216459Rickettsia typhi str. Wilmington, complete genomerickettsial conserved hypothetical protein3e-76283
NC_016915:346000:362404362404362859456Rickettsia rickettsii str. Hlp#2 chromosome, complete genomehypothetical protein2e-52204