Pre_GI: BLASTP Hits

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Query: NC_017066:312000:328057 Rickettsia typhi str. TH1527 chromosome, complete genome

Start: 328057, End: 328704, Length: 648

Host Lineage: Rickettsia typhi; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. R. prowazekii, and genomic comparisons demonstrate colinearity and similarity to the genome of that organism except for two independent inversions near the origin and terminus. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_006142:312000:328031328031328690660Rickettsia typhi str. Wilmington, complete genomeheme exporter protein B4e-89327
NC_017043:1055569:107844010784401079087648Rickettsia montanensis str. OSU 85-930 chromosome, complete genomeheme exporter protein B6e-70263
NC_016915:346000:361682361682362329648Rickettsia rickettsii str. Hlp#2 chromosome, complete genomeheme exporter protein B4e-68257