Pre_GI: BLASTP Hits

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Query: NC_017063:800156:806282 Helicobacter pylori ELS37 chromosome, complete genome

Start: 806282, End: 806881, Length: 600

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017371:530673:536368536368536967600Helicobacter pylori Gambia94/24 chromosome, complete genomecag pathogenicity island protein (cag6)2e-111401
NC_014560:518582:530916530916531515600Helicobacter pylori SJM180 chromosome, complete genomecag pathogenicity island protein (cag6)5e-111399
NC_000921:511642:517340517340517939600Helicobacter pylori J99, complete genomecag island protein9e-111399
NC_000915:547783:553469553469554068600Helicobacter pylori 26695, complete genomecag pathogenicity island protein (cag6)4e-110397
NC_018939:547793:553479553479554078600Helicobacter pylori 26695 chromosome, complete genomecag pathogenicity island protein (cag6)4e-110397
NC_017357:495213:505150505150505749600Helicobacter pylori 908 chromosome, complete genomecag pathogenicity island protein3e-110397
NC_017374:498588:504281504281504880600Helicobacter pylori 2017 chromosome, complete genomecag pathogenicity island protein Z3e-110397
NC_017381:500699:506392506392506991600Helicobacter pylori 2018 chromosome, complete genomecag pathogenicity island protein Z3e-110397
NC_008086:513407:519493519493520092600Helicobacter pylori HPAG1, complete genomecag pathogenicity island protein Z1e-109394
NC_017366:535188:540709540709541308600Helicobacter pylori F32, complete genomecag pathogenicity island protein2e-109394
NC_014256:683384:695683695683696282600Helicobacter pylori B8 chromosome, complete genomecag pathogenicity island protein Z2e-109394
NC_017372:855384:867489867489868088600Helicobacter pylori India7 chromosome, complete genomecag pathogenicity island protein Z2e-109394
NC_017368:852490:864596864596865195600Helicobacter pylori F16, complete genomecag pathogenicity island protein2e-109394
NC_011333:514464:520045520045520644600Helicobacter pylori G27 chromosome, complete genomecag pathogenicity island protein Z5e-109393
NC_014555:502151:507507507507508106600Helicobacter pylori PeCan4 chromosome, complete genomecag pathogenicity island protein Z5e-109393
NC_017367:562918:568442568442569041600Helicobacter pylori F57, complete genomecag pathogenicity island protein1e-108392
NC_011498:553525:559215559215559814600Helicobacter pylori P12, complete genomecag pathogenicity island protein Z8e-109392
NC_017360:1052473:106489210648921065491600Helicobacter pylori 35A chromosome, complete genomecag pathogenicity island protein6e-109392
NC_017375:872478:884590884590885189600Helicobacter pylori 83 chromosome, complete genomecag pathogenicity island protein6e-109392
NC_017376:538000:545077545077545676600Helicobacter pylori SNT49 chromosome, complete genomecag pathogenicity island protein Z6e-109392
NC_017362:506950:512530512530513129600Helicobacter pylori Lithuania75 chromosome, complete genomecag pathogenicity island protein Z6e-109392
NC_010698:819912:838366838366838965600Helicobacter pylori Shi470, complete genomecag pathogenicity island protein Z5e-109392
NC_017358:563336:568684568684569283600Helicobacter pylori Cuz20 chromosome, complete genomecag pathogenicity island protein (cagZ, cag6)5e-109392
NC_017359:813500:825560825560826159600Helicobacter pylori Sat464 chromosome, complete genomecag pathogenicity island protein (cagZ, cag6)5e-109392
NC_017378:502806:508140508140508739600Helicobacter pylori Puno120 chromosome, complete genomecag pathogenicity island protein (cagZ, cag6)5e-109392
NC_017379:505350:511030511030511629600Helicobacter pylori Puno135 chromosome, complete genomecag pathogenicity island protein5e-109392
NC_017354:848500:861111861111861710600Helicobacter pylori 52 chromosome, complete genomecag pathogenicity island protein Z2e-108391
NC_017365:848500:861177861177861776600Helicobacter pylori F30, complete genomecag pathogenicity island protein2e-108390
NC_017355:493237:499146499146499571426Helicobacter pylori v225d chromosome, complete genomecag pathogenicity island protein (cagZ)8e-76282