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Query: NC_017063:775337:790112 Helicobacter pylori ELS37 chromosome, complete genome

Start: 790112, End: 791104, Length: 993

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014560:518582:544503544503545495993Helicobacter pylori SJM180 chromosome, complete genomeconserved hypothetical secreted protein0665
NC_017357:495213:496115496115497107993Helicobacter pylori 908 chromosome, complete genomehypothetical protein0664
NC_014256:683384:711277711277712269993Helicobacter pylori B8 chromosome, complete genomehypothetical protein0660
NC_017375:872478:892337892337893329993Helicobacter pylori 83 chromosome, complete genomehypothetical protein0659
NC_017360:1052473:107264410726441073636993Helicobacter pylori 35A chromosome, complete genomehypothetical protein0657
NC_017365:848500:868927868927869919993Helicobacter pylori F30, complete genomehypothetical protein0655
NC_017359:813500:833182833182834174993Helicobacter pylori Sat464 chromosome, complete genomehypothetical protein0654
NC_017368:852490:872347872347873339993Helicobacter pylori F16, complete genomehypothetical protein0654
NC_017372:855384:875349875349876341993Helicobacter pylori India7 chromosome, complete genomehypothetical protein0654
NC_017354:848500:868720868720869712993Helicobacter pylori 52 chromosome, complete genomehypothetical protein0653
NC_014931:5594946:5596064559606455975901527Variovorax paradoxus EPS chromosome, complete genomeErfK/YbiS/YcfS/YnhG family protein2e-20100
NC_012791:4680500:4682215468221546833391125Variovorax paradoxus S110 chromosome 1, complete genomeErfK/YbiS/YcfS/YnhG family protein3e-2099.4
NC_015138:3160764:3182214318221431835271314Acidovorax avenae subsp. avenae ATCC 19860 chromosome, completeErfK/YbiS/YcfS/YnhG family protein4e-1995.5
NC_014153:436082:4497014497014510441344Thiomonas intermedia K12 chromosome, complete genomeErfK/YbiS/YcfS/YnhG family protein4e-1375.9