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Query: NC_017026:3894000 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 3894000, End: 3916188, Length: 22189

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_009525:39335673933567395892925363Mycobacterium tuberculosis H37Ra, complete genome04280BLASTN svgBLASTP svg
NC_020133:57106615710661573224421584Mycobacterium liflandii 128FXT, complete genome3e-1281.8BLASTN svgBLASTP svg
NC_010612:61131556113155613265419500Mycobacterium marinum M, complete genome3e-1281.8BLASTN svgBLASTP svg
NC_002945:16217651621765164826226498Mycobacterium bovis AF2122/97, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_009565:16297801629780165615326374Mycobacterium tuberculosis F11, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_015848:16475231647523167029122769Mycobacterium canettii CIPT 140010059, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_011896:42766042766044580418145Mycobacterium leprae Br4923, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_002677:42750042750044579518296Mycobacterium leprae TN, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_000962:37815013781501380757326073Mycobacterium tuberculosis H37Rv, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_002755:37737343773734379844824715Mycobacterium tuberculosis CDC1551, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_002945:37351413735141376077425634Mycobacterium bovis AF2122/97, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_008769:37690653769065379470125637Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_009525:37940003794000381625122252Mycobacterium tuberculosis H37Ra, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_009565:37939763793976381869024715Mycobacterium tuberculosis F11, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_012207:37669783766978379261425637Mycobacterium bovis BCG str. Tokyo 172, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_002755:27880002788000281039922400Mycobacterium tuberculosis CDC1551, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_002945:27578212757821278170823888Mycobacterium bovis AF2122/97, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_008769:27548282754828277870723880Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_009525:28029872802987282687923893Mycobacterium tuberculosis H37Ra, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_009565:28060002806000282822922230Mycobacterium tuberculosis F11, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_012207:27475992747599277148023882Mycobacterium bovis BCG str. Tokyo 172, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_015848:28591452859145288297223828Mycobacterium canettii CIPT 140010059, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_019950:28306822830682285444023759Mycobacterium canettii CIPT 140060008 complete genome3e-0661.9BLASTN svgBLASTP svg
NC_020133:48419324841932485992417993Mycobacterium liflandii 128FXT, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_000962:27910192791019281491123893Mycobacterium tuberculosis H37Rv, complete genome3e-0661.9BLASTN svgBLASTP svg