Pre_GI: BLASTP Hits

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Query: NC_017026:476500:490199 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 490199, End: 491017, Length: 819

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:477500:491036491036491854819Mycobacterium bovis BCG str. Mexico chromosome, complete genomebeta lactamase like protein1e-143509
NC_009525:477093:491197491197492015819Mycobacterium tuberculosis H37Ra, complete genomebeta lactamase like protein1e-143509
NC_012207:477500:491035491035491853819Mycobacterium bovis BCG str. Tokyo 172, complete genomebeta lactamase like protein1e-143509
NC_009565:479500:493057493057493875819Mycobacterium tuberculosis F11, complete genomebeta lactamase like protein1e-143509
NC_002945:476835:490906490906491724819Mycobacterium bovis AF2122/97, complete genomebeta lactamase like protein1e-143509
NC_000962:475816:489887489887490705819Mycobacterium tuberculosis H37Rv, complete genomeBETA LACTAMASE LIKE PROTEIN1e-143509
NC_008769:507000:520702520702521520819Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeBeta lactamase like protein1e-143509
NC_012943:476500:490146490146490964819Mycobacterium tuberculosis KZN 1435 chromosome, complete genomebeta lactamase like protein1e-143509
NC_016768:476500:490146490146490964819Mycobacterium tuberculosis KZN 4207 chromosome, complete genomebeta lactamase like protein1e-143509
NC_002755:472872:491336491336492094759Mycobacterium tuberculosis CDC1551, complete genomemetallo-beta-lactamase superfamily protein2e-143508
NC_019950:481881:496219496219496977759Mycobacterium canettii CIPT 140060008 complete genomeConserved protein of unknown function, Beta lactamase like protein1e-142505
NC_010612:835648:851973851973852725753Mycobacterium marinum M, complete genomebeta lactamase-like protein5e-103374
NC_016604:1285277:130718213071821307928747Mycobacterium rhodesiae NBB3 chromosome, complete genomeZn-dependent hydrolase6e-80297
NC_014659:2737843:275260027526002753358759Rhodococcus equi 103S, complete genomemetallo-beta-lactamase superfamily protein1e-39163
NC_009480:99640:106123106123106863741Clavibacter michiganensis subsp. michiganensis NCPPB 382, completehypothetical protein3e-31135
NC_013093:3068486:310917931091793109892714Actinosynnema mirum DSM 43827, complete genomebeta-lactamase domain protein5e-1995.1
NC_013743:1045488:105836410583641059134771Haloterrigena turkmenica DSM 5511, complete genomebeta-lactamase domain protein1e-1686.7
NC_014976:170683:193238193238193939702Bacillus subtilis BSn5 chromosome, complete genomeputative metal-dependent hydrolase2e-1273.2
UCMB5137:1594000:161093016109301611646717Bacillus atrophaeus UCMB-5137putative metal-dependent hydrolase5e-1271.6
NC_003030:1510000:152769415276941528425732Clostridium acetobutylicum ATCC 824, complete genomeZn-dependent hydrolase, glyoxylase family1e-1170.9
NC_015687:1508664:152929515292951530026732Clostridium acetobutylicum DSM 1731 chromosome, complete genomezinc-dependent hydrolase1e-1170.9
NC_017295:1507956:152710815271081527839732Clostridium acetobutylicum EA 2018 chromosome, complete genomeZn-dependent hydrolase, glyoxylase family1e-1170.9
NC_014171:4812340:481586048158604816582723Bacillus thuringiensis BMB171 chromosome, complete genomemetal-dependent hydrolase2e-1169.7
NC_020272:3187482:318869731886973189491795Bacillus amyloliquefaciens IT-45, complete genomemetallo-beta-lactamase family protein3e-1169.3
NC_004722:4899940:490345749034574904179723Bacillus cereus ATCC 14579, complete genomeMetal-dependent hydrolase9e-1167.8
NC_015690:3477573:348890034889003489625726Paenibacillus mucilaginosus KNP414 chromosome, complete genomemetallo-beta-lactamase superfamily protein1e-1067.4
NC_011725:4944072:494759049475904948312723Bacillus cereus B4264 chromosome, complete genomemetallo-beta-lactamase1e-1067.4
NC_016935:4038265:404713840471384047863726Paenibacillus mucilaginosus 3016 chromosome, complete genomemetallo-beta-lactamase superfamily protein9e-1167.4
NC_010184:4791000:479415447941544794876723Bacillus weihenstephanensis KBAB4, complete genomebeta-lactamase domain protein2e-1066.2
NC_002607:169721:195274195274195984711Halobacterium sp. NRC-1, complete genomehypothetical protein4e-1065.5
NC_012659:4745053:475111047511104751832723Bacillus anthracis str. A0248, complete genomemetallo-beta-lactamase family protein5e-1065.1
NC_005945:4747740:475241947524194753141723Bacillus anthracis str. Sterne, complete genomemetallo-beta-lactamase family protein5e-1065.1
NC_007530:4744870:475121047512104751932723Bacillus anthracis str. 'Ames Ancestor', complete genomemetallo-beta-lactamase family protein5e-1065.1
NC_003997:4745027:475108447510844751806723Bacillus anthracis str. Ames, complete genomemetallo-beta-lactamase family protein5e-1065.1
NC_003909:4737882:474207447420744742796723Bacillus cereus ATCC 10987, complete genomemetallo-beta-lactamase family protein6e-1064.7
NC_005957:4757215:476205747620574762779723Bacillus thuringiensis serovar konkukian str. 97-27, completemetallo-beta-lactamase family protein1e-0963.9
NC_017208:4996992:500154350015435002265723Bacillus thuringiensis serovar chinensis CT-43 chromosome, completemetal-dependent hydrolase1e-0963.5
NC_010681:1202929:122522812252281226019792Burkholderia phytofirmans PsJN chromosome 1, complete sequencebeta-lactamase domain protein3e-0962.8
NC_017200:4814000:481772848177284818450723Bacillus thuringiensis serovar finitimus YBT-020 chromosome,metallo-beta-lactamase family protein3e-0962.4
NC_016113:1143580:115168111516811152361681Streptomyces cattleya NRRL 8057 plasmid pSCAT, complete sequenceZn-dependent hydrolase6e-0961.6
NC_014212:3206860:322136232213623221997636Meiothermus silvanus DSM 9946 chromosome, complete genomebeta-lactamase domain protein1e-0860.5
NC_012914:5618000:562293356229335623661729Paenibacillus sp. JDR-2, complete genomebeta-lactamase domain protein1e-0860.5
NC_014831:285759:288973288973289875903Thermaerobacter marianensis DSM 12885 chromosome, complete genomebeta-lactamase domain-containing protein1e-0860.5
NC_019897:2696587:271848127184812719467987Thermobacillus composti KWC4 chromosome, complete genomeZn-dependent hydrolase1e-0860.5
NC_011000:2831183:284226928422692843060792Burkholderia cenocepacia J2315 chromosome 1, complete sequencemetallo-beta-lactamase superfamily protein2e-0859.7
NC_002689:979191:981501981501982439939Thermoplasma volcanium GSS1, complete genomeZn-dependent hydrolase2e-0859.7
NC_015589:2555000:255948625594862560319834Desulfotomaculum ruminis DSM 2154 chromosome, complete genomebeta-lactamase domain-containing protein1e-0757
NC_015589:3340500:334471233447123345449738Desulfotomaculum ruminis DSM 2154 chromosome, complete genomebeta-lactamase domain-containing protein3e-0755.8
NC_007761:1097531:1112240111224011135561317Rhizobium etli CFN 42, complete genomeputative alkyl sulfatase beta-lactamase family protein6e-0755.1
NC_006582:4256915:427572442757244276518795Bacillus clausii KSM-K16, complete genomemetal-dependent hydrolase6e-0754.7
NC_011899:2165814:218576821857682186559792Halothermothrix orenii H 168, complete genomebeta-lactamase domain protein8e-0754.3
NC_021182:4829000:485616748561674856952786Clostridium pasteurianum BC1, complete genomemetal-dependent hydrolase, beta-lactamase superfamily I1e-0653.5
NC_015499:1493500:150670815067081507589882Thermodesulfobium narugense DSM 14796 chromosome, complete genomebeta-lactamase domain protein3e-0652.8
NC_018080:4436646:445254044525404453298759Pseudomonas aeruginosa DK2 chromosome, complete genomehypothetical protein4e-0652