Pre_GI: BLASTP Hits

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Query: NC_017026:476500:483533 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 483533, End: 483961, Length: 429

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:477500:484376484376484804429Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein3e-62236
NC_002945:476835:484246484246484674429Mycobacterium bovis AF2122/97, complete genomemembrane protein3e-62236
NC_000962:475816:483228483228483656429Mycobacterium tuberculosis H37Rv, complete genomePROBABLE CONSERVED MEMBRANE PROTEIN MMPS13e-62236
NC_009565:479500:486398486398486826429Mycobacterium tuberculosis F11, complete genomemembrane protein mmpS13e-62236
NC_009525:477093:484538484538484966429Mycobacterium tuberculosis H37Ra, complete genomeputative conserved membrane protein MmpS13e-62236
NC_008769:507000:514042514042514470429Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative membrane protein mmpS13e-62236
NC_012207:477500:484375484375484803429Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein3e-62236
NC_012943:476500:483487483487483915429Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein3e-62236
NC_016768:476500:483487483487483915429Mycobacterium tuberculosis KZN 4207 chromosome, complete genomemembrane protein mmpS13e-62236
NC_019950:481881:489566489566489994429Mycobacterium canettii CIPT 140060008 complete genomeConserved membrane protein of unknown function MmpS1_18e-61231
NC_015848:483500:490517490517490945429Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein8e-61231
NC_002755:472872:484650484650485105456Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein2e-49194
NC_010612:835648:841984841984842412429Mycobacterium marinum M, complete genomeconserved membrane protein MmpS1_13e-40163
NC_002944:4163490:418597741859774186441465Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpS18e-25112
NC_017904:2379387:241902524190252419429405Mycobacterium sp. MOTT36Y chromosome, complete genomeMmpS4 protein9e-25112
NC_010612:90890:981909819098627438Mycobacterium marinum M, complete genomeconserved membrane protein MmpS5_38e-24108
NC_008596:421882:425344425344425763420Mycobacterium smegmatis str. MC2 155, complete genomeMmpS4 protein1e-22104
NC_010397:4150596:418154341815434181959417Mycobacterium abscessus chromosome Chromosome, complete sequencePutative membrane protein, MmpS family5e-22102
NC_016947:3309898:332112933211293321731603Mycobacterium intracellulare MOTT-02 chromosome, complete genomemmpS4 protein6e-22102
NC_016948:3381848:339307033930703393672603Mycobacterium intracellulare MOTT-64 chromosome, complete genomemmpS4 protein6e-22102
NC_002944:1285436:130768113076811308100420Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpS43e-21100
NC_017904:3415700:342712934271293427527399Mycobacterium sp. MOTT36Y chromosome, complete genomemmpS4 protein8e-1992.4
NC_002944:1881405:189882618988261899242417Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpS57e-1889.4
NC_017904:2641270:264417026441702644586417Mycobacterium sp. MOTT36Y chromosome, complete genomemmpS5 protein2e-1787.8
NC_014168:2575799:258605025860502586499450Segniliparus rotundus DSM 44985 chromosome, complete genomehypothetical protein2e-1684.3
NC_016948:1796989:180917618091761809607432Mycobacterium intracellulare MOTT-64 chromosome, complete genomehypothetical protein4e-1683.6
NC_016947:70210:836298362984051423Mycobacterium intracellulare MOTT-02 chromosome, complete genomeMmpS family protein9e-1682
NC_010397:4387500:439051243905124390943432Mycobacterium abscessus chromosome Chromosome, complete sequencePutative membrane protein, MmpS family2e-1581.3
NC_014168:1294000:131343613134361313966531Segniliparus rotundus DSM 44985 chromosome, complete genomehypothetical protein2e-1580.9
NC_020133:942375:946025946025946462438Mycobacterium liflandii 128FXT, complete genomeconserved membrane protein MmpS-family4e-1476.6
NC_010612:3969244:398280839828083983197390Mycobacterium marinum M, complete genomeconserved transmembrane protein2e-1374.7
NC_020133:3787844:379259737925973793028432Mycobacterium liflandii 128FXT, complete genomeconserved transmembrane protein2e-1374.3