Pre_GI: BLASTP Hits

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Query: NC_017026:476500:481398 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 481398, End: 483536, Length: 2139

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:2715651:2717477271747727199002424Bacillus anthracis str. A0248, complete genome4e-1480.5
NC_006274:2779380:2780666278066627837913126Bacillus cereus E33L, complete genomeconserved hypothetical protein; two MmpL domains3e-1377.8
NC_002677:1462233:1462233146223314651842952Mycobacterium leprae TN, complete genomeconserved large membrane protein2e-57224
NC_007181:1766910:1782228178222817844742247Sulfolobus acidocaldarius DSM 639, complete genomeconserved Prokaryal membrane protein3e-1067.4
NC_010612:3969244:3979902397990239828112910Mycobacterium marinum M, complete genomeconserved transmembrane transport protein - MmpL family2e-173609
NC_010612:3969244:3976045397604539789542910Mycobacterium marinum M, complete genomeconserved transmembrane transport protein - MmpL family5e-167588
NC_010612:835648:8391118391118419872877Mycobacterium marinum M, complete genomeconserved transmembrane transport protein MmpL10895
NC_010612:90890:9532995329981932865Mycobacterium marinum M, complete genomeconserved transmembrane transport protein, MmpL5_30699
NC_013510:747042:7532997532997556892391Thermomonospora curvata DSM 43183, complete genomedrug exporter of the RND superfamily-like protein5e-0653.5
NC_006958:628035:6375476375476397392193Corynebacterium glutamicum ATCC 13032, complete genomedrug exporter, RND superfamily3e-1274.3
NC_014032:71724:7535975359779082550Salinibacter ruber M8 chromosome, complete genomeexporter7e-0653.1
NC_018876:1121268:1145755114575511480042250Methanolobus psychrophilus R15 chromosome, complete genomehydrophobe/amphiphile efflux-3 (HAE3) family transporter3e-0654.3
NC_006270:568171:5681715681715712903120Bacillus licheniformis ATCC 14580, complete genomehypothetical protein6e-1996.7
NC_005945:2716000:2717912271791227203442433Bacillus anthracis str. Sterne, complete genomehypothetical protein3e-1480.9
NC_011773:2782465:2782465278246527851312667Bacillus cereus AH820 chromosome, complete genomehypothetical protein1e-1275.5
NC_015562:1460124:1494887149488714960471161Methanotorris igneus Kol 5 chromosome, complete genomehypothetical protein1e-0758.9
NC_002677:173170:1892531892531919612709Mycobacterium leprae TN, complete genomehypothetical protein5e-29129
NC_018528:1681060:1703587170358717072913705Lactobacillus helveticus R0052 chromosome, complete genomehypothetical protein9e-1995.9
NC_015848:3343731:3343731334373133464932763Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein1e-1585.5
NC_009342:795500:8170388170388192302193Corynebacterium glutamicum R chromosome, complete genomehypothetical protein4e-1170.9
NC_007677:71532:7515275152777012550Salinibacter ruber DSM 13855, complete genomehypothetical protein7e-0653.1
NC_011896:1462258:1462258146225814652092952Mycobacterium leprae Br4923, complete genomehypothetical protein2e-57224
NC_011896:173197:1892801892801919882709Mycobacterium leprae Br4923, complete genomehypothetical protein5e-29129
NC_011969:2706000:2707523270752327106393117Bacillus cereus Q1 chromosome, complete genomehypothetical protein1e-1378.6
NC_003888:7866148:7877335787733578795812247Streptomyces coelicolor A3(2), complete genomeintegral membrane protein8e-0859.7
NC_003888:7866148:7866148786614878682982151Streptomyces coelicolor A3(2), complete genomeintegral membrane protein3e-1171.2
NC_009142:2692693:2713075271307527152612187Saccharopolyspora erythraea NRRL 2338, complete genomeintegral membrane protein, MmpL family3e-1067.8
NC_014335:2718000:2719357271935727224733117Bacillus cereus biovar anthracis str. CI chromosome, completemembrane protein7e-1479.7
NC_002936:797110:7992957992958022402946Dehalococcoides ethenogenes 195, complete genomemembrane protein, MmpL family1e-27125
NC_005957:2756000:2756118275611827592433126Bacillus thuringiensis serovar konkukian str. 97-27, completemembrane protein, MmpL family5e-1480.5
NC_016779:2693790:2693790269379026969063117Bacillus cereus F837/76 chromosome, complete genomemembrane protein, MmpL family1e-1275.5
NC_012581:1505276:1518690151869015211132424Bacillus anthracis str. CDC 684 chromosome, complete genomemembrane protein, MmpL family4e-1480.5
NC_002755:472872:4804464804464833222877Mycobacterium tuberculosis CDC1551, complete genomemembrane protein, MmpL family01202
NC_011772:2860000:2862262286226228653783117Bacillus cereus G9842, complete genomemembrane protein, MmpL family1e-1585.9
NC_008600:2792584:2792584279258427957093126Bacillus thuringiensis str. Al Hakam, complete genomemembrane protein, MmpL family2e-1275.1
NC_003909:2798622:2798622279862228017383117Bacillus cereus ATCC 10987, complete genomemembrane protein, MmpL family, putative5e-1273.6
NC_017904:3415700:3427590342759034304152826Mycobacterium sp. MOTT36Y chromosome, complete genomemmp14A protein3e-176619
NC_016947:3309898:3321728332172833246852958Mycobacterium intracellulare MOTT-02 chromosome, complete genomemmp14A protein6e-177621
NC_016948:3381848:3393669339366933965632895Mycobacterium intracellulare MOTT-64 chromosome, complete genomemmp14A protein2e-177622
NC_008596:421882:4257604257604286422883Mycobacterium smegmatis str. MC2 155, complete genomeMmp14a protein9e-175614
NC_008146:5106775:5124292512429251273603069Mycobacterium sp. MCS, complete genomeMMPL4e-65249
NC_013510:5394432:5394432539443253968492418Thermomonospora curvata DSM 43183, complete genomeMMPL domain protein1e-0862.4
NC_009921:3854969:3869841386984138723392499Frankia sp. EAN1pec, complete genomeMMPL domain protein9e-0756.2
NC_009921:4399000:4413784441378444161652382Frankia sp. EAN1pec, complete genomeMMPL domain protein2e-0861.6
NC_013441:2788806:2817878281787828209193042Gordonia bronchialis DSM 43247, complete genomeMMPL domain protein2e-69264
NC_013174:23421:3049330493315511059Jonesia denitrificans DSM 20603, complete genomeMMPL domain protein2e-0965.1
NC_013093:5922777:5934962593496259370102049Actinosynnema mirum DSM 43827, complete genomeMMPL domain protein1e-0759.3
NC_008699:2294361:2313454231345423164953042Nocardioides sp. JS614, complete genomeMMPL domain protein4e-56219
NC_008705:5144433:5163375516337551664433069Mycobacterium sp. KMS, complete genomeMMPL domain protein4e-65249
NC_009077:4810379:4818713481871348218353123Mycobacterium sp. JLS, complete genomeMMPL domain protein1e-62241
NC_013510:991827:1009826100982610119672142Thermomonospora curvata DSM 43183, complete genomeMMPL domain protein3e-1067.4
NC_015953:4045500:4045584404558440478092226Streptomyces sp. SirexAA-E chromosome, complete genomeMMPL domain-containing protein4e-0963.9
NC_015634:2991669:3007351300735130095552205Bacillus coagulans 2-6 chromosome, complete genomeMMPL domain-containing protein3e-0860.8
NC_014168:2575799:2583216258321625860532838Segniliparus rotundus DSM 44985 chromosome, complete genomeMMPL domain-containing protein4e-132472
NC_013947:5431741:5448200544820054504222223Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeMMPL domain-containing protein4e-0963.9
NC_015957:6859259:6871667687166768738892223Streptomyces violaceusniger Tu 4113 chromosome, complete genomeMMPL domain-containing protein1e-0862
NC_009338:4913510:4930736493073649327812046Mycobacterium gilvum PYR-GCK chromosome, complete genomeMMPL domain-containing protein1e-61238
NC_015172:1195782:1199795119979512028783084Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeMmpL domain-containing protein4e-0963.9
NC_013947:1570000:1591872159187215939862115Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeMMPL domain-containing protein1e-0862
NC_015949:1767552:1789109178910917921893081Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomeMMPL domain-containing protein2e-0655.5
NC_014393:4352216:4375707437570743788533147Clostridium cellulovorans 743B chromosome, complete genomeMmpL domain-containing protein2e-20101
NC_013947:1537275:1539173153917315413832211Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeMMPL domain-containing protein1e-0965.9
NC_016582:9076686:9076686907668690790792394Streptomyces bingchenggensis BCW-1 chromosome, complete genomeMMPL family protein2e-1068.6
NC_016947:70210:8074780747836322886Mycobacterium intracellulare MOTT-02 chromosome, complete genomeMmpL family protein7e-173607
NC_016947:666627:6801266801266831222997Mycobacterium intracellulare MOTT-02 chromosome, complete genomeMmpL family transport protein4e-64246
NC_017904:666285:6780176780176809622946Mycobacterium sp. MOTT36Y chromosome, complete genomeMmpL family transport protein7e-65249
NC_017904:2379387:2419426241942624223232898Mycobacterium sp. MOTT36Y chromosome, complete genomeMmpL4 protein1e-179630
NC_016948:3381848:3396653339665333995682916Mycobacterium intracellulare MOTT-64 chromosome, complete genomemmpL4_20652
NC_002944:1285436:1301816130181613047342919Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpL4_20647
NC_016947:3309898:332471033247103325273564Mycobacterium intracellulare MOTT-02 chromosome, complete genomemmpL4_22e-51204
NC_017904:3415700:3430505343050534334202916Mycobacterium sp. MOTT36Y chromosome, complete genomemmpL4_20650
NC_016947:3309898:3325257332525733276262370Mycobacterium intracellulare MOTT-02 chromosome, complete genomemmpL4_29e-126451
NC_002944:1285436:1304793130479313076842892Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpL4_38e-179627
NC_002944:4163490:4186438418643841893772940Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpL4_50710
NC_016948:1796989:1809658180965818124682811Mycobacterium intracellulare MOTT-64 chromosome, complete genomemmpL4_60634
NC_002944:1881405:1899239189923919021392901Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpL50647
NC_017904:2641270:2641270264127026441732904Mycobacterium sp. MOTT36Y chromosome, complete genomemmpL50645
NC_017208:2942554:2944492294449229476083117Bacillus thuringiensis serovar chinensis CT-43 chromosome, completePhage infection protein6e-1996.7
NC_009464:2015035:2015035201503520186013567Uncultured methanogenic archaeon RC-I, complete genomepredicted drug exporter (acriflavin resistance protein family)7e-0963.2
NC_000962:475816:4803554803554832312877Mycobacterium tuberculosis H37Rv, complete genomePROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL101202
NC_003888:6470909:6470909647090964734522544Streptomyces coelicolor A3(2), complete genomeprobable export protein2e-1585.1
NC_010545:2229125:2251454225145422538592406Corynebacterium urealyticum DSM 7109, complete genomeputative drug exporter of the RND superfamily4e-0653.9
NC_014550:2835696:2850986285098628531272142Arthrobacter arilaitensis Re117, complete genomeputative drug exporter of the RND superfamily6e-1790.1
NC_007164:2261644:2270199227019922723732175Corynebacterium jeikeium K411, complete genomeputative drug exporter of the RND superfamily6e-1066.6
NC_018583:95388:1015351015351045673033Gordonia sp. KTR9 plasmid pGKT3, complete sequenceputative drug exporters, RND superfamily5e-64246
NC_018583:95388:1124971124971155473051Gordonia sp. KTR9 plasmid pGKT3, complete sequenceputative drug exporters, RND superfamily8e-71268
NC_008711:3701635:3708060370806037104022343Arthrobacter aurescens TC1, complete genomeputative integral membrane protein, MMPL family6e-1066.6
NC_010397:4150596:4178667417866741815462880Mycobacterium abscessus chromosome Chromosome, complete sequencePutative membrane protein, MmpL2e-179629
NC_010397:4150596:4175704417570441786672964Mycobacterium abscessus chromosome Chromosome, complete sequencePutative membrane protein, MmpL5e-165582
NC_020387:745353:7458437458437487672925Dehalococcoides mccartyi BTF08, complete genomeputative membrane protein, MMPL family4e-24113
NC_010397:4387500:4387612438761243905152904Mycobacterium abscessus chromosome Chromosome, complete sequencePutative membrane protein, MmpL family9e-175614
NC_019950:3306419:3308199330819933109162718Mycobacterium canettii CIPT 140060008 complete genomePutative membrane transport protein MmpL75e-1686.7
NC_016887:1714664:1758481175848117606402160Nocardia cyriacigeorgica GUH-2, complete genomeputative Multidrug efflux transporter AcrB transmembrane domain7e-0653.1
NC_016804:477500:4815044815044826071104Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane transport protein5e-0757
NC_016804:1679357:1696909169690917002323324Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane transport protein3e-46187
NC_016804:477500:4826044826044843791776Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane transport protein01089
NC_012207:2573562:2584562258456225870422481Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane transport protein0662
NC_012207:477500:4815034815034826061104Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane transport protein5e-0757
NC_012207:477500:4826034826034843781776Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane transport protein01089
NC_016804:2560000:2571155257115525736352481Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane transport protein0662
NC_012207:1681971:1699523169952317028463324Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane transport protein3e-46187
NC_019950:481881:4866934866934895692877Mycobacterium canettii CIPT 140060008 complete genomePutative transmembrane transport protein MmpL101200
NC_015848:483500:4876444876444905202877Mycobacterium canettii CIPT 140010059, complete genomeputative transmembrane transport protein MMPL101200
NC_008769:1709078:1726630172663017299533324Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transmembrane transport protein mmpL123e-46187
NC_008769:507000:5122705122705140451776Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transmembrane transport protein mmpL1a01089
NC_008769:507000:5111705111705122731104Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transmembrane transport protein mmpL1b5e-0757
NC_008596:421882:4286524286524316362985Mycobacterium smegmatis str. MC2 155, complete genomeputative transport protein9e-174610
NC_019892:8124070:8137293813729381397132421Singulisphaera acidiphila DSM 18658 chromosome, complete genomeRND superfamily drug exporter3e-30134
NC_014814:1397429:1417525141752514206473123Mycobacterium sp. Spyr1 chromosome, complete genomeRND superfamily drug exporter1e-60234
NC_003450:627500:6360866360866382242139Corynebacterium glutamicum ATCC 13032, complete genomeRND superfamily drug exporter4e-1273.9
NC_015602:1339067:1360744136074413641153372Lactobacillus kefiranofaciens ZW3 chromosome, complete genomeRND superfamily resistance-nodulation-cell division:proton (H+) antiporter8e-2099.4
NC_009525:477093:4816654816654845412877Mycobacterium tuberculosis H37Ra, complete genometransmembrane transport protein MmpL101202
NC_009565:479500:4835254835254864012877Mycobacterium tuberculosis F11, complete genometransmembrane transport protein mmpL101202
NC_002945:1680751:1698302169830217016253324Mycobacterium bovis AF2122/97, complete genometransmembrane transport protein MmpL123e-46187
NC_002945:476835:4824744824744842491776Mycobacterium bovis AF2122/97, complete genometransmembrane transport protein MmpL1A01089
NC_002945:476835:4813744813744824771104Mycobacterium bovis AF2122/97, complete genometransmembrane transport protein MmpL1B5e-0757
NC_012943:476500:4806144806144834902877Mycobacterium tuberculosis KZN 1435 chromosome, complete genometransmembrane transporter mmpL101202
NC_016768:476500:4806144806144834902877Mycobacterium tuberculosis KZN 4207 chromosome, complete genometransmembrane transporter mmpL101202
NC_014168:1294000:1310581131058113134392859Segniliparus rotundus DSM 44985 chromosome, complete genometransport protein0650
NC_013929:8474195:8485235848523584875052271Streptomyces scabiei 87.22 chromosome, complete genometransporter4e-0963.9
NC_006322:567987:5679875679875711063120Bacillus licheniformis ATCC 14580, complete genomeYdgH6e-1996.7