Pre_GI: BLASTP Hits

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Query: NC_017026:476500:480659 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 480659, End: 481357, Length: 699

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015848:483500:4876444876444905202877Mycobacterium canettii CIPT 140010059, complete genomeputative transmembrane transport protein MMPL12e-129461
NC_009525:477093:4816654816654845412877Mycobacterium tuberculosis H37Ra, complete genometransmembrane transport protein MmpL12e-129461
NC_009565:479500:4835254835254864012877Mycobacterium tuberculosis F11, complete genometransmembrane transport protein mmpL12e-129461
NC_000962:475816:4803554803554832312877Mycobacterium tuberculosis H37Rv, complete genomePROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL12e-129461
NC_002755:472872:4804464804464833222877Mycobacterium tuberculosis CDC1551, complete genomemembrane protein, MmpL family2e-129461
NC_012943:476500:4806144806144834902877Mycobacterium tuberculosis KZN 1435 chromosome, complete genometransmembrane transporter mmpL12e-129461
NC_016768:476500:4806144806144834902877Mycobacterium tuberculosis KZN 4207 chromosome, complete genometransmembrane transporter mmpL12e-129461
NC_008769:507000:5111705111705122731104Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transmembrane transport protein mmpL1b2e-129461
NC_012207:477500:4815034815034826061104Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane transport protein2e-129461
NC_002945:476835:4813744813744824771104Mycobacterium bovis AF2122/97, complete genometransmembrane transport protein MmpL1B2e-129461
NC_016804:477500:4815044815044826071104Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane transport protein2e-129461
NC_019950:481881:4866934866934895692877Mycobacterium canettii CIPT 140060008 complete genomePutative transmembrane transport protein MmpL12e-129461
NC_010612:835648:8391118391118419872877Mycobacterium marinum M, complete genomeconserved transmembrane transport protein MmpL18e-106382
NC_017904:3415700:3430505343050534334202916Mycobacterium sp. MOTT36Y chromosome, complete genomemmpL4_21e-79296
NC_002944:1285436:1301816130181613047342919Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpL4_21e-79296
NC_010612:90890:9532995329981932865Mycobacterium marinum M, complete genomeconserved transmembrane transport protein, MmpL5_38e-80296
NC_002944:1881405:1899239189923919021392901Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpL57e-80296
NC_016948:3381848:3396653339665333995682916Mycobacterium intracellulare MOTT-64 chromosome, complete genomemmpL4_21e-79295
NC_017904:2641270:2641270264127026441732904Mycobacterium sp. MOTT36Y chromosome, complete genomemmpL51e-79295
NC_016947:3309898:3325257332525733276262370Mycobacterium intracellulare MOTT-02 chromosome, complete genomemmpL4_22e-79295
NC_014168:1294000:1310581131058113134392859Segniliparus rotundus DSM 44985 chromosome, complete genometransport protein1e-78292
NC_010397:4150596:4175704417570441786672964Mycobacterium abscessus chromosome Chromosome, complete sequencePutative membrane protein, MmpL1e-77289
NC_002944:1285436:1304793130479313076842892Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpL4_34e-77287
NC_008596:421882:4286524286524316362985Mycobacterium smegmatis str. MC2 155, complete genomeputative transport protein1e-76285
NC_008596:421882:4257604257604286422883Mycobacterium smegmatis str. MC2 155, complete genomeMmp14a protein5e-76283
NC_010397:4150596:4178667417866741815462880Mycobacterium abscessus chromosome Chromosome, complete sequencePutative membrane protein, MmpL7e-76283
NC_016948:3381848:3393669339366933965632895Mycobacterium intracellulare MOTT-64 chromosome, complete genomemmp14A protein2e-74278
NC_017904:3415700:3427590342759034304152826Mycobacterium sp. MOTT36Y chromosome, complete genomemmp14A protein3e-74278
NC_017904:2379387:2419426241942624223232898Mycobacterium sp. MOTT36Y chromosome, complete genomeMmpL4 protein3e-73275
NC_010612:3969244:3976045397604539789542910Mycobacterium marinum M, complete genomeconserved transmembrane transport protein - MmpL family1e-70266
NC_002944:4163490:4186438418643841893772940Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpL4_57e-71266
NC_010612:3969244:3979902397990239828112910Mycobacterium marinum M, complete genomeconserved transmembrane transport protein - MmpL family1e-70265
NC_010397:4387500:4387612438761243905152904Mycobacterium abscessus chromosome Chromosome, complete sequencePutative membrane protein, MmpL family6e-70263
NC_016948:1796989:1809658180965818124682811Mycobacterium intracellulare MOTT-64 chromosome, complete genomemmpL4_67e-69260
NC_014168:2575799:2583216258321625860532838Segniliparus rotundus DSM 44985 chromosome, complete genomeMMPL domain-containing protein1e-65249
NC_016947:70210:8074780747836322886Mycobacterium intracellulare MOTT-02 chromosome, complete genomeMmpL family protein3e-62238
NC_012207:2573562:258705525870552587450396Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane transport protein7e-43173
NC_016804:2560000:257364825736482574043396Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane transport protein7e-43173
NC_002945:1680751:1698302169830217016253324Mycobacterium bovis AF2122/97, complete genometransmembrane transport protein MmpL126e-38157
NC_016804:1679357:1696909169690917002323324Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane transport protein1e-37156
NC_012207:1681971:1699523169952317028463324Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane transport protein1e-37156
NC_008769:1709078:1726630172663017299533324Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transmembrane transport protein mmpL121e-37156
NC_002677:1462233:1462233146223314651842952Mycobacterium leprae TN, complete genomeconserved large membrane protein4e-35147
NC_011896:1462258:1462258146225814652092952Mycobacterium leprae Br4923, complete genomehypothetical protein4e-35147
NC_016947:666627:6801266801266831222997Mycobacterium intracellulare MOTT-02 chromosome, complete genomeMmpL family transport protein2e-33142
NC_018583:95388:1015351015351045673033Gordonia sp. KTR9 plasmid pGKT3, complete sequenceputative drug exporters, RND superfamily3e-33141
NC_017904:666285:6780176780176809622946Mycobacterium sp. MOTT36Y chromosome, complete genomeMmpL family transport protein8e-30130
NC_013441:2788806:2817878281787828209193042Gordonia bronchialis DSM 43247, complete genomeMMPL domain protein1e-27123
NC_018583:95388:1124971124971155473051Gordonia sp. KTR9 plasmid pGKT3, complete sequenceputative drug exporters, RND superfamily2e-27122
NC_008146:5106775:5124292512429251273603069Mycobacterium sp. MCS, complete genomeMMPL3e-27122
NC_008705:5144433:5163375516337551664433069Mycobacterium sp. KMS, complete genomeMMPL domain protein3e-27122
NC_012207:2573562:2584562258456225870422481Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane transport protein2e-26119
NC_016804:2560000:2571155257115525736352481Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane transport protein2e-26119
NC_009338:4913510:4933711493371149351231413Mycobacterium gilvum PYR-GCK chromosome, complete genomeMMPL domain-containing protein2e-26119
NC_014814:1397429:1417525141752514206473123Mycobacterium sp. Spyr1 chromosome, complete genomeRND superfamily drug exporter5e-26117
NC_009077:4810379:4818713481871348218353123Mycobacterium sp. JLS, complete genomeMMPL domain protein6e-26117
NC_008699:2294361:2313454231345423164953042Nocardioides sp. JS614, complete genomeMMPL domain protein4e-24111
NC_006958:628035:6375476375476397392193Corynebacterium glutamicum ATCC 13032, complete genomedrug exporter, RND superfamily2e-21102
NC_003450:627500:6360866360866382242139Corynebacterium glutamicum ATCC 13032, complete genomeRND superfamily drug exporter2e-21102
NC_020387:745353:7458437458437487672925Dehalococcoides mccartyi BTF08, complete genomeputative membrane protein, MMPL family3e-21102
NC_009342:795500:8170388170388192302193Corynebacterium glutamicum R chromosome, complete genomehypothetical protein4e-21101
NC_002936:797110:7992957992958022402946Dehalococcoides ethenogenes 195, complete genomemembrane protein, MmpL family1e-2099.8
NC_013093:5922777:5934962593496259370102049Actinosynnema mirum DSM 43827, complete genomeMMPL domain protein1e-2099.8
NC_003888:7866148:7866148786614878682982151Streptomyces coelicolor A3(2), complete genomeintegral membrane protein1e-2099.8
NC_013521:1713416:1725755172575517280822328Sanguibacter keddieii DSM 10542, complete genomepredicted RND superfamily drug exporter2e-2099
NC_009380:3903392:3922739392273939248832145Salinispora tropica CNB-440 chromosome, complete genomeMMPL domain-containing protein3e-2098.6
NC_006270:568171:5681715681715712903120Bacillus licheniformis ATCC 14580, complete genomehypothetical protein2e-1995.9
NC_006322:567987:5679875679875711063120Bacillus licheniformis ATCC 14580, complete genomeYdgH2e-1995.9
NC_013510:991827:1009826100982610119672142Thermomonospora curvata DSM 43183, complete genomeMMPL domain protein2e-1995.9
NC_003106:1899691:1918971191897119214842514Sulfolobus tokodaii str. 7, complete genomehypothetical antibiotic transport-associated protein2e-1789.7
NC_014550:2835696:2850986285098628531272142Arthrobacter arilaitensis Re117, complete genomeputative drug exporter of the RND superfamily7e-1787.4
NC_003909:2798622:2798622279862228017383117Bacillus cereus ATCC 10987, complete genomemembrane protein, MmpL family, putative2e-1685.9
NC_011969:2706000:2707523270752327106393117Bacillus cereus Q1 chromosome, complete genomehypothetical protein3e-1685.5
NC_006274:2779380:2780666278066627837913126Bacillus cereus E33L, complete genomeconserved hypothetical protein; two MmpL domains3e-1685.5
NC_019892:8124070:8137293813729381397132421Singulisphaera acidiphila DSM 18658 chromosome, complete genomeRND superfamily drug exporter4e-1685.1
NC_011772:2860000:2862262286226228653783117Bacillus cereus G9842, complete genomemembrane protein, MmpL family6e-1684.3
NC_017208:2942554:2944492294449229476083117Bacillus thuringiensis serovar chinensis CT-43 chromosome, completePhage infection protein2e-1582.8
NC_005957:2756000:2756118275611827592433126Bacillus thuringiensis serovar konkukian str. 97-27, completemembrane protein, MmpL family3e-1582
NC_014335:2718000:2719357271935727224733117Bacillus cereus biovar anthracis str. CI chromosome, completemembrane protein4e-1581.6
NC_016779:2693790:2693790269379026969063117Bacillus cereus F837/76 chromosome, complete genomemembrane protein, MmpL family5e-1581.3
NC_008600:2792584:2792584279258427957093126Bacillus thuringiensis str. Al Hakam, complete genomemembrane protein, MmpL family6e-1581.3
NC_011773:2782465:2782465278246527851312667Bacillus cereus AH820 chromosome, complete genomehypothetical protein1e-1480.5
NC_008711:3701635:3708060370806037104022343Arthrobacter aurescens TC1, complete genomeputative integral membrane protein, MMPL family9e-1477
NC_013947:1570000:1591872159187215939862115Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeMMPL domain-containing protein1e-1376.6
NC_009921:8717659:8737976873797687401472172Frankia sp. EAN1pec, complete genomeMmpL domain protein5e-1374.7
NC_015660:3518931:3541386354138635436112226Geobacillus thermoglucosidasius C56-YS93 chromosome, completeMMPL domain-containing protein9e-1373.9
NC_005877:665092:6650926650926677672676Picrophilus torridus DSM 9790, complete genometransporter involved in lipid transport2e-1273.2
NC_015634:2991669:3007351300735130095552205Bacillus coagulans 2-6 chromosome, complete genomeMMPL domain-containing protein5e-1271.2
NC_007777:3824291:3828393382839338309032511Frankia sp. CcI3, complete genomeMMPL6e-1271.2
NC_013929:8474195:8485235848523584875052271Streptomyces scabiei 87.22 chromosome, complete genometransporter7e-1270.9
NC_009464:2015035:2015035201503520186013567Uncultured methanogenic archaeon RC-I, complete genomepredicted drug exporter (acriflavin resistance protein family)2e-1169.7
NC_010545:2229125:2251454225145422538592406Corynebacterium urealyticum DSM 7109, complete genomeputative drug exporter of the RND superfamily3e-1168.9
NC_013131:8480384:8481951848195184840652115Catenulispora acidiphila DSM 44928, complete genomeMmpL domain-containing protein6e-1167.8
NC_015949:1767552:1789109178910917921893081Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomeMMPL domain-containing protein2e-1066.2
NC_003888:6470909:6470909647090964734522544Streptomyces coelicolor A3(2), complete genomeprobable export protein2e-1066.2
NC_009380:4184695:4203090420309042052972208Salinispora tropica CNB-440 chromosome, complete genomeMMPL domain-containing protein1e-0963.2
NC_009338:4913510:4930736493073649327812046Mycobacterium gilvum PYR-GCK chromosome, complete genomeMMPL domain-containing protein1e-0963.2
NC_017955:2494640:2515024251502425171832160Modestobacter marinus, complete genometransmembrane multidrug efflux transporter2e-0963.2
NC_009921:3854969:3869841386984138723392499Frankia sp. EAN1pec, complete genomeMMPL domain protein2e-0963.2
NC_018528:1681060:1703587170358717072913705Lactobacillus helveticus R0052 chromosome, complete genomehypothetical protein2e-0962.4
NC_015656:2484749:2513235251323525154842250Frankia symbiont of Datisca glomerata chromosome, complete genomeMMPL domain-containing protein3e-0962
NC_013510:4319296:4320175432017543223282154Thermomonospora curvata DSM 43183, complete genomeMMPL domain protein3e-0962
NC_015602:1339067:1360744136074413641153372Lactobacillus kefiranofaciens ZW3 chromosome, complete genomeRND superfamily resistance-nodulation-cell division:proton (H+) antiporter7e-0960.8
NC_014393:4352216:4375707437570743788533147Clostridium cellulovorans 743B chromosome, complete genomeMmpL domain-containing protein8e-0960.8
NC_007181:1766910:1782228178222817844742247Sulfolobus acidocaldarius DSM 639, complete genomeconserved Prokaryal membrane protein1e-0860.5
NC_007164:2261644:2270199227019922723732175Corynebacterium jeikeium K411, complete genomeputative drug exporter of the RND superfamily1e-0860.1
NC_010572:188500:2111482111482134182271Streptomyces griseus subsp. griseus NBRC 13350, complete genomeputative transmembrane transport protein2e-0859.3
NC_020133:4889034:4905108490510849071952088Mycobacterium liflandii 128FXT, complete genometransmembrane transport protein MmpL135e-0858.2
NC_016947:3309898:3321728332172833246852958Mycobacterium intracellulare MOTT-02 chromosome, complete genomemmp14A protein8e-0857.4
NC_012659:2715651:271678527167852717282498Bacillus anthracis str. A0248, complete genome8e-0857.4
NC_012581:1505276:152130815213081521805498Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein8e-0857.4
NC_005945:2716000:271722027172202717717498Bacillus anthracis str. Sterne, complete genomehypothetical protein8e-0857.4
NC_013929:6526745:6545143654514365473952253Streptomyces scabiei 87.22 chromosome, complete genomehypothetical protein1e-0757
NC_014643:892138:9141449141449153341191Rothia dentocariosa ATCC 17931 chromosome, complete genomeMMPL family integral membrane protein2e-0756.6
NC_016801:170876:1927411927411950772337Corynebacterium diphtheriae C7 (beta) chromosome, complete genomeputative drug exporter of the RND superfamily1e-0756.6
NC_009953:1581088:1600205160020516024902286Salinispora arenicola CNS-205 chromosome, complete genomeMMPL domain-containing protein2e-0756.2
NC_015949:1767552:1772259177225917733231065Caldicellulosiruptor lactoaceticus 6A chromosome, complete genome3e-0755.5
NC_010545:1729161:1736545173654517389022358Corynebacterium urealyticum DSM 7109, complete genomeputative drug exporter of the RND superfamily4e-0755.1
NC_016790:134951:1542801542801566162337Corynebacterium diphtheriae VA01 chromosome, complete genomeputative drug exporter of the RND superfamily7e-0754.3
NC_015172:1195782:1199795119979512028783084Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeMmpL domain-containing protein4e-0651.6
NC_009921:4399000:4413784441378444161652382Frankia sp. EAN1pec, complete genomeMMPL domain protein1e-0550.4