Pre_GI: BLASTP Hits

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Query: NC_017026:476500:480091 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 480091, End: 480462, Length: 372

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:477500:480938480938481309372Mycobacterium bovis BCG str. Mexico chromosome, complete genometransmembrane protein3e-37153
NC_002755:472872:479880479880480251372Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein3e-37153
NC_009525:477093:481099481099481470372Mycobacterium tuberculosis H37Ra, complete genomeputative conserved transmembrane protein3e-37153
NC_012207:477500:480937480937481308372Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane protein3e-37153
NC_002945:476835:480808480808481179372Mycobacterium bovis AF2122/97, complete genometransmembrane protein3e-37153
NC_008769:507000:510604510604510975372Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transmembrane protein3e-37153
NC_000962:475816:479789479789480160372Mycobacterium tuberculosis H37Rv, complete genomePROBABLE CONSERVED TRANSMEMBRANE PROTEIN3e-37153
NC_009565:479500:482959482959483330372Mycobacterium tuberculosis F11, complete genomeconserved transmembrane protein3e-37153
NC_012943:476500:480048480048480419372Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein3e-37153
NC_016768:476500:480048480048480419372Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein3e-37153
NC_015848:483500:487078487078487449372Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein9e-37152
NC_019950:481881:486127486127486498372Mycobacterium canettii CIPT 140060008 complete genomeConserved membrane protein of unknown function9e-37152
NC_010617:1428902:143336114333611433738378Kocuria rhizophila DC2201, complete genomehypothetical protein1e-1065.1
NC_007333:537292:550441550441550815375Thermobifida fusca YX, complete genomehypothetical protein2e-0754.7