Pre_GI: BLASTP Hits

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Query: NC_017026:476500:477627 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 477627, End: 478856, Length: 1230

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:477500:4784764784764797051230Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative lipoprotein0765
NC_002945:476835:4783464783464795751230Mycobacterium bovis AF2122/97, complete genomelipoprotein LpqK0765
NC_008769:507000:5081425081425093711230Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative lipoprotein lpqK0765
NC_009525:477093:4786374786374798661230Mycobacterium tuberculosis H37Ra, complete genomeputative conserved lipoprotein LpqK0765
NC_012207:477500:4784754784754797041230Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative lipoprotein0765
NC_002755:472872:4774184774184786471230Mycobacterium tuberculosis CDC1551, complete genomelipoprotein, putative0765
NC_009565:479500:4804974804974817261230Mycobacterium tuberculosis F11, complete genomelipoprotein lpqK0765
NC_000962:475816:4773274773274785561230Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE CONSERVED LIPOPROTEIN LPQK0765
NC_012943:476500:4775864775864788151230Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein0762
NC_016768:476500:4775864775864788151230Mycobacterium tuberculosis KZN 4207 chromosome, complete genomelipoprotein LpqK0762
NC_015848:483500:4846164846164858451230Mycobacterium canettii CIPT 140010059, complete genomeputative lipoprotein LPQK0755
NC_019950:481881:4836654836654848941230Mycobacterium canettii CIPT 140060008 complete genomeConserved lipoprotein of unknown function, lipoprotein LpqK0752
NC_013757:2630000:2641547264154726427971251Geodermatophilus obscurus DSM 43160, complete genomebeta-lactamase1e-20101
NC_010546:3071377:3073581307358130789535373Cyanothece sp. ATCC 51142 chromosome circular, complete sequencehypothetical protein3e-2099.8
NC_019673:189487:2064942064942076901197Saccharothrix espanaensis DSM 44229 complete genomeAlkaline D-peptidase9e-2098.2
NC_017186:3947874:3965203396520339662941092Amycolatopsis mediterranei S699 chromosome, complete genomebeta-lactamase class C2e-1997.4
NC_014318:3947845:3965174396517439662651092Amycolatopsis mediterranei U32 chromosome, complete genomebeta-lactamase class C2e-1997.4
NC_014666:4547873:4548457454845745496651209Frankia sp. EuI1c chromosome, complete genomebeta-lactamase2e-1997.1
NC_002939:1505701:1506745150674515077581014Geobacter sulfurreducens PCA, complete genomebeta-lactamase4e-1996.3
NC_013757:2630000:2640277264027726414581182Geodermatophilus obscurus DSM 43160, complete genomebeta-lactamase2e-1893.6
NC_015690:4361000:4424844442484444259951152Paenibacillus mucilaginosus KNP414 chromosome, complete genomeAlkaline D-peptidase and alkaline D-peptidase fusion3e-1893.2
NC_010397:1802724:1802724180272418068484125Mycobacterium abscessus chromosome Chromosome, complete sequenceBacteriophage protein4e-1892.8
NC_016935:4117485:4190913419091341920641152Paenibacillus mucilaginosus 3016 chromosome, complete genomealkaline D-peptidase6e-1892.4
NC_012491:6143928:6165290616529061664741185Brevibacillus brevis NBRC 100599, complete genomeputative D-stereospecific peptide hydrolase6e-1892
NC_013729:4871430:4887632488763248887861155Kribbella flavida DSM 17836, complete genomebeta-lactamase3e-1789.7
NC_016935:7426389:7436208743620874383642157Paenibacillus mucilaginosus 3016 chromosome, complete genomealkaline D-peptidase, serine peptidase, merops family s122e-1687.4
NC_015690:7334786:7344146734414673463052160Paenibacillus mucilaginosus KNP414 chromosome, complete genomealkaline D-peptidase; serine peptidase; merops family s123e-1686.7
NC_013235:402819:4080774080774092221146Nakamurella multipartita DSM 44233, complete genomebeta-lactamase4e-1686.3
NC_014622:4922977:4980081498008149812381158Paenibacillus polymyxa SC2 chromosome, complete genomed-alanyl-d-alanine carboxypeptidase (penicillin-binding protein)1e-1584.3
NC_015957:7348269:7390957739095773921741218Streptomyces violaceusniger Tu 4113 chromosome, complete genomebeta-lactamase2e-1584
NC_015957:7348269:7389614738961473908401227Streptomyces violaceusniger Tu 4113 chromosome, complete genomebeta-lactamase3e-1583.2
NC_015953:3456535:3504980350498035061971218Streptomyces sp. SirexAA-E chromosome, complete genomebeta-lactamase2e-1480.5
NC_013947:3534209:3552144355214435533941251Stackebrandtia nassauensis DSM 44728 chromosome, complete genomebeta-lactamase5e-1479.3
NC_020126:6019850:6035252603525260367211470Myxococcus stipitatus DSM 14675, complete genomebeta-lactamase7e-1478.6
NC_013595:606096:6154686154686167841317Streptosporangium roseum DSM 43021, complete genomeserine-type D-Ala-D-Ala carboxypeptidase9e-1478.2
NC_016609:4834378:4858265485826548595931329Niastella koreensis GR20-10 chromosome, complete genomebeta-lactamase7e-1375.5
NC_013929:4807910:4810032481003248112131182Streptomyces scabiei 87.22 chromosome, complete genomepeptidase1e-1274.7
NC_009380:2310000:2315040231504023163051266Salinispora tropica CNB-440 chromosome, complete genomeSerine-type D-Ala-D-Ala carboxypeptidase2e-1273.6
NC_014623:9492000:9492963949296394941681206Stigmatella aurantiaca DW4/3-1 chromosome, complete genomebeta-lactamase family protein5e-1272.4
NC_013595:5282207:5289928528992852914721545Streptosporangium roseum DSM 43021, complete genomeBeta-lactamase class C and other penicillin binding protein-like protein2e-1170.9
NC_009664:4377777:4377777437777743790301254Kineococcus radiotolerans SRS30216, complete genomeSerine-type D-Ala-D-Ala carboxypeptidase2e-1170.9
NC_013947:4979000:4995657499565749970451389Stackebrandtia nassauensis DSM 44728 chromosome, complete genomebeta-lactamase3e-1170.1
NC_013510:1295439:1299340129934013007191380Thermomonospora curvata DSM 43183, complete genomebeta-lactamase4e-1169.3
NC_013406:3672857:367881836788183679288471Paenibacillus sp. Y412MC10 chromosome, complete genomeserine-type D-Ala-D-Ala carboxypeptidase1e-1068.2
NC_020126:6019850:6033705603370560351741470Myxococcus stipitatus DSM 14675, complete genomebeta-lactamase2e-1067
NC_015588:2468207:2484809248480924862031395Isoptericola variabilis 225 chromosome, complete genomebeta-lactamase1e-0964.7
NC_013222:1898164:190692019069201907873954Robiginitalea biformata HTCC2501, complete genomeserine-type D-Ala-D-Ala carboxypeptidase5e-0962.8
NC_013222:1659619:1664564166456416656551092Robiginitalea biformata HTCC2501, complete genomebeta-lactamase precursor6e-0962.4
NC_014816:545441:5637285637285654191692Asticcacaulis excentricus CB 48 chromosome 1, complete sequencebeta-lactamase6e-0962.4
NC_011830:3081726:3092393309239330934091017Desulfitobacterium hafniense DCB-2, complete genomebeta-lactamase1e-0861.6
NC_014165:374674:3916893916893931371449Thermobispora bispora DSM 43833 chromosome, complete genomebeta-lactamase1e-0861.6
NC_007907:1996194:2007506200750620085221017Desulfitobacterium hafniense Y51, complete genomehypothetical protein1e-0861.6
NC_013947:460398:4867104867104878551146Stackebrandtia nassauensis DSM 44728 chromosome, complete genomebeta-lactamase2e-0860.8
NC_008228:2295841:2305171230517123062801110Pseudoalteromonas atlantica T6c, complete genomebeta-lactamase2e-0860.5
NC_014623:6150028:6160545616054561698419297Stigmatella aurantiaca DW4/3-1 chromosome, complete genomeLgrB-like linear gramicidin synthetase subunit B protein4e-0859.7
NC_016609:4152977:4160567416056741617451179Niastella koreensis GR20-10 chromosome, complete genomebeta-lactamase7e-0858.9
NC_013169:1058463:1062742106274210640071266Kytococcus sedentarius DSM 20547, complete genomepenicillin-binding protein, beta-lactamase class C9e-0858.5
NC_014834:959986:9909259909259921991275Rhodopseudomonas palustris DX-1 chromosome, complete genomebeta-lactamase9e-0858.5
NC_008095:2450500:2465541246554124669531413Myxococcus xanthus DK 1622, complete genomebeta-lactamase1e-0758.2
NC_007802:1991211:200289420028942003718825Jannaschia sp. CCS1, complete genomebeta-lactamase1e-0757.8
NC_013730:4440943:4446568444656844481991632Spirosoma linguale DSM 74, complete genomebeta-lactamase4e-0756.2
NC_014328:3823902:3843374384337438452121839Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative beta-lactamase4e-0756.2
NC_010407:410918:4305044305044319521449Clavibacter michiganensis subsp. sepedonicus chromosome, completeputative beta-lactamase5e-0756.2
NC_013730:5989387:5989387598938759906341248Spirosoma linguale DSM 74, complete genomebeta-lactamase5e-0755.8
NC_013222:1659619:1667037166703716683261290Robiginitalea biformata HTCC2501, complete genomeBeta-lactamase6e-0755.8
NC_013757:1888850:1916158191615819174141257Geodermatophilus obscurus DSM 43160, complete genomebeta-lactamase7e-0755.5
NC_013166:194614:1999531999532016321680Kangiella koreensis DSM 16069, complete genomebeta-lactamase6e-0755.5
NC_006347:4031000:4040529404052940421421614Bacteroides fragilis YCH46, complete genomeputative peptidase1e-0654.7
NC_003228:3934770:3944283394428339458961614Bacteroides fragilis NCTC 9343, complete genomeputative exported beta-lactamase protein1e-0654.7
NC_016776:3973428:3982941398294139845541614Bacteroides fragilis 638R, complete genomeputative exported beta-lactamase protein1e-0654.7
NC_009665:1831674:1836699183669918379311233Shewanella baltica OS185 chromosome, complete genomebeta-lactamase2e-0653.5
NC_020054:6111419:6140268614026861415211254Fibrella aestuarina BUZ 2 drat genomebeta-lactamase3e-0653.1
NC_018678:2140182:215831521583152159238924Alteromonas macleodii str. 'English Channel 673' chromosome,beta-lactamase7e-0652
NC_015761:1181186:1186601118660111882321632Salmonella bongori NCTC 12419, complete genomebeta-lactamase8e-0652
NC_020126:8984500:8988091898809189894581368Myxococcus stipitatus DSM 14675, complete genomebeta-lactamase1e-0551.6