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Query: NC_017026:476500:476979 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 476979, End: 477620, Length: 642

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:477500:477828477828478469642Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein6e-93339
NC_002945:476835:477698477698478339642Mycobacterium bovis AF2122/97, complete genomehypothetical protein6e-93339
NC_008769:507000:507494507494508135642Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative secreted protein6e-93339
NC_012207:477500:477827477827478468642Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative secreted protein6e-93339
NC_002755:472872:476770476770477411642Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein6e-93339
NC_009525:477093:477989477989478630642Mycobacterium tuberculosis H37Ra, complete genomeputative secreted protein6e-93339
NC_009565:479500:479849479849480490642Mycobacterium tuberculosis F11, complete genomehypothetical secreted protein6e-93339
NC_000962:475816:476679476679477320642Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE SECRETED PROTEIN6e-93339
NC_012943:476500:476938476938477579642Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein6e-93339
NC_016768:476500:476938476938477579642Mycobacterium tuberculosis KZN 4207 chromosome, complete genomesecreted protein6e-93339
NC_019950:481881:483017483017483658642Mycobacterium canettii CIPT 140060008 complete genomeConserved secreted protein of unknown function2e-92338
NC_015848:483500:483968483968484609642Mycobacterium canettii CIPT 140010059, complete genomeputative secreted protein2e-92338