Pre_GI: BLASTP Hits

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Query: NC_017026:3282405:3301525 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 3301525, End: 3302490, Length: 966

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000962:3288464:330758033075803308545966Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein1e-176619
NC_015848:3343731:336420133642013365166966Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein1e-176619
NC_009525:3300456:331957233195723320537966Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein1e-176619
NC_009565:3299937:331905333190533320018966Mycobacterium tuberculosis F11, complete genomehypothetical protein1e-176619
NC_002755:3282785:330190033019003302874975Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein2e-176618
NC_008769:3242453:326174132617413262706966Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein5e-176616
NC_012207:3237440:325456832545683255533966Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein5e-176616
NC_002945:3246278:326426832642683265233966Mycobacterium bovis AF2122/97, complete genomehypothetical protein5e-176616
NC_016804:3221818:324110632411063242071966Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein5e-176616
NC_019950:3306419:332851033285103329301792Mycobacterium canettii CIPT 140060008 complete genomehypothetical protein1e-148526
NC_007775:1002934:1020398102039810242493852Synechococcus sp. JA-3-3Ab, complete genomemethyltransferase, FkbM family6e-1891.7
NC_015496:2279829:230194423019442302819876Krokinobacter diaphorus 4H-3-7-5 chromosome, complete genomemethyltransferase FkbM family3e-1686.3
NC_011832:366092:374900374900375670771Candidatus Methanosphaerula palustris E1-9c, complete genomemethyltransferase FkbM family2e-1377
NC_009921:2565640:257128325712832572248966Frankia sp. EAN1pec, complete genomemethyltransferase FkbM family3e-1376.3
NC_015596:1511961:1519441151944115225693129Sinorhizobium meliloti AK83 chromosome 2, complete sequenceFkbM family methyltransferase4e-1375.5
NC_015510:3641676:364989836498983650773876Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomeFkbM family methyltransferase7e-1375.1
NC_014507:758820:7807817807817818031023Methanoplanus petrolearius DSM 11571 chromosome, complete genomemethyltransferase FkbM family1e-1274.3
NC_011666:3001513:300842730084273009224798Methylocella silvestris BL2, complete genomemethyltransferase FkbM family8e-1271.6
NC_011071:3544450:355438335543833555270888Stenotrophomonas maltophilia R551-3, complete genomemethyltransferase FkbM family1e-1170.9
NC_009483:1936486:195784719578471958737891Geobacter uraniireducens Rf4 chromosome, complete genomeFkbM family methyltransferase1e-1170.5
NC_014205:842314:857464857464858288825Staphylothermus hellenicus DSM 12710 chromosome, complete genomemethyltransferase FkbM family1e-1170.5
NC_007776:474361:4856834856834893183636Synechococcus sp. JA-2-3B'a(2-13), complete genomemethyltransferase, FkbM family2e-1170.1
NC_010172:5036385:504295250429525043785834Methylobacterium extorquens PA1, complete genomemethyltransferase FkbM family2e-1170.1
NC_014006:2999500:3008749300874930103171569Sphingobium japonicum UT26S chromosome 1, complete genomeputative methyltransferase3e-1169.3
NC_008212:1082006:109731310973131098029717Haloquadratum walsbyi DSM 16790, complete genomeS-adenosylmethionine-dependent methyltransferase homolog7e-1168.2
NC_017904:3415700:343988934398893440575687Mycobacterium sp. MOTT36Y chromosome, complete genomeFkbM family methyltransferase1e-1067.4
NC_013960:379461:3794613794613845155055Nitrosococcus halophilus Nc4 chromosome, complete genomemethyltransferase FkbM family1e-1067.4
NC_011884:2051723:206894220689422069712771Cyanothece sp. PCC 7425, complete genomemethyltransferase FkbM family4e-1065.9
NC_010172:4064087:407249840724984073337840Methylobacterium extorquens PA1, complete genomemethyltransferase FkbM family4e-1065.5
NC_002977:1198438:121046112104611211366906Methylococcus capsulatus str. Bath, complete genomemethyltransferase, FkbM family6e-1065.1
NC_015377:34445:478014780148601801Burkholderia gladioli BSR3 plasmid bgla_2p, complete sequencemethyltransferase FkbM family6e-1065.1
NC_014394:1373602:138976513897651390676912Gallionella capsiferriformans ES-2 chromosome, complete genomemethyltransferase FkbM family1e-0963.9
NC_005027:1304887:130488713048871305777891Rhodopirellula baltica SH 1, complete genomeconserved hypothetical protein-putative methyltransferase4e-0962.4
NC_015315:1:189341893419482549Thermoproteus uzoniensis 768-20 chromosome, complete genomehypothetical protein4e-0962.4
NC_015593:2841856:286333528633352864234900Sphingobium chlorophenolicum L-1 chromosome chromosome 1, completeFkbM family methyltransferase5e-0962
NC_015186:347346:367887367887368660774Acidiphilium multivorum AIU301, complete genomemethyltransferase FkbM family protein1e-0861.2
NC_007761:781210:806935806935807684750Rhizobium etli CFN 42, complete genomelipopolysaccharide biosynthesis protein (SAM-dependent methyltransferase protein)2e-0860.5
NC_009937:3324793:333558033355803336365786Azorhizobium caulinodans ORS 571, complete genomemethyltransferase2e-0860.1
NC_017323:599549:626325626325627071747Sinorhizobium meliloti BL225C plasmid pSINMEB02, complete sequenceFkbM family methyltransferase3e-0859.7
NC_002678:426000:4293844293844304841101Mesorhizobium loti MAFF303099, complete genomehypothetical protein3e-0859.7
NC_007947:797456:804487804487805338852Methylobacillus flagellatus KT, complete genomeMethyltransferase FkbM3e-0859.3
NC_007761:781210:807701807701808561861Rhizobium etli CFN 42, complete genomelipolysaccharide tri-O-methyl-fucosylation protein (SAM-dependent methyltransferase protein)3e-0859.3
NC_002754:705741:710062710062710967906Sulfolobus solfataricus P2, complete genomehypothetical protein4e-0859.3
NC_015666:1623790:164442316444231645262840Halopiger xanaduensis SH-6 chromosome, complete genomeFkbM family methyltransferase4e-0859.3
NC_008228:1404126:141619514161951417094900Pseudoalteromonas atlantica T6c, complete genomemethyltransferase FkbM family5e-0858.9
NC_002977:1198438:120779412077941208579786Methylococcus capsulatus str. Bath, complete genomehypothetical protein9e-0858.2
NC_013769:914000:930962930962931936975Sulfolobus islandicus L.D.8.5 chromosome, complete genomeFkbM family methyltransferase1e-0757.8
NC_017904:3415700:344221034422103442857648Mycobacterium sp. MOTT36Y chromosome, complete genomeFkbM family methyltransferase2e-0757
NC_020541:625925:632216632216632980765Rhodanobacter sp. 2APBS1, complete genomemethyltransferase, FkbM family2e-0756.6
NC_008536:5861495:587940658794065880119714Solibacter usitatus Ellin6076, complete genomemethyltransferase FkbM family3e-0756.2
NC_009484:318500:3366313366313379951365Acidiphilium cryptum JF-5 chromosome, complete genomeFkbM family methyltransferase4e-0755.8
NC_014729:1627620:164151316415131642238726Halogeometricum borinquense DSM 11551 chromosome, complete genomemethyltransferase, fkbm family6e-0755.1
NC_007614:261588:274497274497275330834Nitrosospira multiformis ATCC 25196 chromosome 1, completeMethyltransferase FkbM6e-0755.1
NC_006834:787500:793593793593794393801Xanthomonas oryzae pv. oryzae KACC10331, complete genomehypothetical protein1e-0654.7
NC_012850:459315:470623470623471375753Rhizobium leguminosarum bv. trifolii WSM1325, complete genomemethyltransferase FkbM family9e-0754.7
NC_010717:4626178:464146146414614642261801Xanthomonas oryzae pv. oryzae PXO99A, complete genomeputative methyltransferase1e-0654.3
NC_007705:755948:762025762025762753729Xanthomonas oryzae pv. oryzae MAFF 311018, complete genomehypothetical protein1e-0653.9
NC_013967:1375255:138555313855531386272720Haloferax volcanii DS2 chromosome, complete genomemethyltransferase AglP2e-0653.5
NC_016629:1111619:113694311369431137827885Desulfovibrio africanus str. Walvis Bay chromosome, completeFkbM family methyltransferase2e-0653.1
NC_014815:841484:857589857589858383795Micromonospora sp. L5 chromosome, complete genomemethyltransferase fkbm family4e-0652.4
NC_008698:1612873:165527116552711656095825Thermofilum pendens Hrk 5, complete genomemethyltransferase FkbM family7e-0651.6