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Query: NC_017026:3282405:3300611 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 3300611, End: 3301336, Length: 726

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015848:3343731:336328733632873364012726Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein6e-141499
NC_019950:3306419:332759633275963328321726Mycobacterium canettii CIPT 140060008 complete genomehypothetical protein6e-141499
NC_009565:3299937:331813933181393318864726Mycobacterium tuberculosis F11, complete genomehypothetical protein6e-141499
NC_000962:3288464:330666633066663307391726Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein6e-141499
NC_002945:3246278:326335432633543264079726Mycobacterium bovis AF2122/97, complete genomehypothetical protein6e-141499
NC_009525:3300456:331865833186583319383726Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein6e-141499
NC_016804:3221818:324019232401923240917726Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein1e-140498
NC_008769:3242453:326082732608273261552726Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein1e-140498
NC_012207:3237440:325365432536543254379726Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein1e-140498
NC_002755:3282785:330098733009873301586600Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein6e-115413