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Query: NC_017026:1095753:1117220 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 1117220, End: 1117837, Length: 618

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:1095846:111729911172991117916618Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein4e-106383
NC_002945:1095337:111698211169821117599618Mycobacterium bovis AF2122/97, complete genomehypothetical protein4e-106383
NC_009525:1096386:111783911178391118456618Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein4e-106383
NC_008769:1125567:114702011470201147637618Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein4e-106383
NC_015656:1876627:188922018892201890020801Frankia symbiont of Datisca glomerata chromosome, complete genomehypothetical protein1e-28125
NC_009441:4449500:446901644690164469636621Flavobacterium johnsoniae UW101 chromosome, complete genomealkylated DNA repair protein-like protein6e-1477.4
NC_015572:2262374:228060322806032281199597Methylomonas methanica MC09 chromosome, complete genome2OG-Fe(II) oxygenase4e-1168.2
NC_008740:2989856:299458529945852995190606Marinobacter aquaeolei VT8, complete genome2OG-Fe(II) oxygenase2e-1065.5
NC_016940:995500:101323610132361013874639Saprospira grandis str. Lewin chromosome, complete genome2OG-Fe(II) oxygenase5e-1064.3
NC_014655:130636:137830137830138432603Leadbetterella byssophila DSM 17132 chromosome, complete genomeDNA-n1-methyladenine dioxygenase2e-0962.4
NC_007952:1293024:131859513185951319206612Burkholderia xenovorans LB400 chromosome 2, complete sequenceoxidoreductase, 2OG-Fe(II) oxygenase family2e-0755.8