Pre_GI: BLASTP Hits

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Query: NC_017026:1095753:1112301 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 1112301, End: 1112912, Length: 612

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:1095846:111238011123801112991612Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative ribosomal-protein-S5p-alanine acetyltransferase1e-102372
NC_009525:1096386:111292011129201113531612Mycobacterium tuberculosis H37Ra, complete genomeribosomal-protein-alanine acetyltransferase RimJ1e-102372
NC_015848:1105892:112241911224191123030612Mycobacterium canettii CIPT 140010059, complete genomeputative ribosomal-protein-alanine acetyltransferase RIMJ1e-102372
NC_012207:1097228:111376211137621114373612Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative ribosomal-protein-alanine acetyltransferase1e-102372
NC_002945:1095337:111206311120631112674612Mycobacterium bovis AF2122/97, complete genomeribosomal-protein-alanine acetyltransferase1e-102372
NC_008769:1125567:114210111421011142712612Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative ribosomal-protein-alanine acetyltransferase rimJ1e-102372
NC_002755:1095105:111165111116511112262612Mycobacterium tuberculosis CDC1551, complete genomeribosomal-protein-alanine acetyltransferase1e-102372
NC_000962:1095078:111161211116121112223612Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE RIBOSOMAL-PROTEIN-ALANINE ACETYLTRANSFERASE RIMJ (ACETYLATING ENZYME FOR N-TERMINAL OF RIBOSOMAL PROTEIN S5)1e-102372
NC_016768:3296478:329647832964783297089612Mycobacterium tuberculosis KZN 4207 chromosome, complete genomeribosomal-protein-alanine acetyltransferase rimJ1e-102372
NC_012943:3299744:329974432997443300397654Mycobacterium tuberculosis KZN 1435 chromosome, complete genomeribosomal-protein-alanine acetyltransferase rimJ6e-102369
NC_009565:1098847:111533811153381115991654Mycobacterium tuberculosis F11, complete genomeribosomal protein alanine acetyltransferase rimJ6e-102369
NC_010397:1099312:110071211007121101365654Mycobacterium abscessus chromosome Chromosome, complete sequencePossible ribosomal-protein-alanine acetyltransferase RimJ6e-78290
NC_006361:5146000:516953551695355170185651Nocardia farcinica IFM 10152, complete genomeputative ribosomal-protein-alanine N-acetyltransferase2e-64244
NC_015312:848403:850542850542851210669Pseudonocardia dioxanivorans CB1190 chromosome, complete genomeGCN5-like N-acetyltransferase2e-53208
NC_017186:9120711:914970491497049150372669Amycolatopsis mediterranei S699 chromosome, complete genomeribosomal-protein-alanine N-acetyltransferase7e-53206
NC_014168:471000:484868484868485533666Segniliparus rotundus DSM 44985 chromosome, complete genomeGCN5-related N-acetyltransferase6e-46183
NC_012669:1011473:101349710134971014090594Beutenbergia cavernae DSM 12333, complete genomeGCN5-related protein N-acetyltransferase1e-31136
NC_010407:32960:463124631246980669Clavibacter michiganensis subsp. sepedonicus chromosome, completeputative GCN5-related N-acetyltransferase6e-28123
NC_008699:833737:837326837326837919594Nocardioides sp. JS614, complete genomeGCN5-related N-acetyltransferase5e-24110
NC_014246:536338:555977555977556672696Mobiluncus curtisii ATCC 43063 chromosome, complete genomeputative ribosomal-protein-S5-alanine acetyltransferase1e-21102
NC_014215:1929000:194643619464361947146711Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1,ribosomal-protein-alanine acetyltransferase5e-21100
NC_008268:6149576:615682561568256157523699Rhodococcus sp. RHA1, complete genomepossible ribosomal-protein-alanine N-acetyltransferase2e-2099.4
NC_021064:1789980:180799318079931808700708Propionibacterium avidum 44067, complete genomeputative ribosomal-protein-alanine acetyltransferase1e-1995.9
NC_015425:2690448:272659327265932727531939Clostridium botulinum BKT015925 chromosome, complete genomeputative ribosomal-protein (S5)-alanine N-acetyltransferase2e-1892.4
NC_008593:2457594:249248524924852493423939Clostridium novyi NT, complete genomeprobable ribosomal-protein (S5)-alanine N-acetyltransferase2e-1788.6
NC_013521:2193203:219385021938502194437588Sanguibacter keddieii DSM 10542, complete genomeacetyltransferase, ribosomal protein N-acetylase2e-1685.9
NC_021182:93000:116081116081117019939Clostridium pasteurianum BC1, complete genomeacetyltransferase, ribosomal protein N-acetylase1e-1582.8
NC_010723:3395187:342927134292713430218948Clostridium botulinum E3 str. Alaska E43, complete genomeacetyltransferase, gnat family2e-1582.4
NC_010516:42475:472134721348157945Clostridium botulinum B1 str. Okra, complete genomeacetyltransferase, GNAT family4e-1581.3
NC_009380:2548878:257268325726832573252570Salinispora tropica CNB-440 chromosome, complete genomeN-acetyltransferase GCN55e-1580.9
NC_010520:35845:413284132842272945Clostridium botulinum A3 str. Loch Maree, complete genomeacetyltransferase, GNAT family6e-1580.5
NC_014393:92500:107781107781108707927Clostridium cellulovorans 743B chromosome, complete genomeRibosomal-protein-alanine N-acetyltransferase1e-1479.7
NC_012563:36000:415364153642480945Clostridium botulinum A2 str. Kyoto, complete genomeacetyltransferase, GNAT family1e-1479.7
NC_009495:38000:471224712248066945Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeGNAT family acetyltransferase1e-1479.7
NC_009697:38000:471374713748081945Clostridium botulinum A str. ATCC 19397 chromosome, completeacetyltransferase1e-1479.7
NC_009698:38000:471374713748081945Clostridium botulinum A str. Hall chromosome, complete genomeacetyltransferase1e-1479.7
NC_009699:33452:424794247943423945Clostridium botulinum F str. Langeland chromosome, complete genomeacetyltransferase1e-1479.7
NC_017297:33519:425474254743491945Clostridium botulinum F str. 230613 chromosome, complete genomeGNAT family acetyltransferase1e-1479.7
NC_012658:35500:411124111242056945Clostridium botulinum Ba4 str. 657 chromosome, complete genomeGNAT family acetyltransferase2e-1479
NC_014328:85290:916329163292576945Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeribosomal-protein-alanine acetyltransferase2e-1375.5
NC_020244:1264500:126479612647961265344549Bacillus subtilis XF-1, complete genomeputative ribosomal-protein-alanine N-acetyltransferase3e-1375.1
NC_014330:337546:357764357764358318555Brachyspira pilosicoli 95/1000 chromosome, complete genomeribosomal-protein-alanine acetyltransferase3e-1375.1
NC_019896:2805098:280867328086732809218546Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completehypothetical protein3e-1375.1
NC_014976:3469395:347171434717143472259546Bacillus subtilis BSn5 chromosome, complete genomeputative ribosomal-protein-alanine N-acetyltransferase6e-1374.3
NC_017195:1230485:123388212338821234427546Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completeYjcK8e-1373.6
NC_008261:64678:707157071571299585Clostridium perfringens ATCC 13124, complete genomeacetyltransferase, GNAT family8e-1373.6
NC_003366:64908:705907059071528939Clostridium perfringens str. 13, complete genomeprobable ribosomal-protein (S5)-alanine N-acetyltransferase1e-1273.2
NC_008262:67711:733777337774315939Clostridium perfringens SM101, complete genomeacetyltransferase, GNAT family2e-1272.4
NC_006322:741516:745113745113745655543Bacillus licheniformis ATCC 14580, complete genomeYjcK2e-1272.4
NC_015687:155554:156963156963157901939Clostridium acetobutylicum DSM 1731 chromosome, complete genomeribosomal-protein-alanine acetyltransferase2e-1272.4
NC_003030:155554:156963156963157901939Clostridium acetobutylicum ATCC 824, complete genomeRibosomal-protein-alanine acetyltransferase (acetylating enzyme for N-terminal of ribosomal protein S5)2e-1272.4
NC_011770:3735162:375892237589223759491570Pseudomonas aeruginosa LESB58, complete genomeribosomal protein alanine acetyltransferase2e-1272.4
NC_020209:2119845:213348721334872134035549Pseudomonas poae RE*1-1-14, complete genomeribosomal protein alanine acetyltransferase2e-1272
NC_018080:3448392:346378834637883464411624Pseudomonas aeruginosa DK2 chromosome, complete genomeribosomal protein alanine acetyltransferase3e-1272
NC_010407:151599:168205168205168771567Clavibacter michiganensis subsp. sepedonicus chromosome, completeputative ribosomal-protein-alanine acetyltransferase1e-1169.7
NC_017047:1796000:181503218150321815619588Rahnella aquatilis HX2 chromosome, complete genomeribosomal-protein-S5-alanine N-acetyltransferase1e-1169.7
NC_007907:1547539:155746415574641558015552Desulfitobacterium hafniense Y51, complete genomehypothetical protein1e-1169.7
NC_011830:2623346:264340926434092643960552Desulfitobacterium hafniense DCB-2, complete genomeGCN5-related N-acetyltransferase1e-1169.7
NC_015957:10505870:105196601051966010520226567Streptomyces violaceusniger Tu 4113 chromosome, complete genomeGCN5-like N-acetyltransferase1e-1169.3
NC_008391:2045348:205565820556582056224567Burkholderia cepacia AMMD chromosome 2, complete sequenceacetyltransferase, including N-acetylases of ribosomal protein2e-1169.3
NC_008463:3503576:352282135228213523390570Pseudomonas aeruginosa UCBPP-PA14, complete genomeribosomal protein alanine acetyltransferase2e-1168.9
NC_014118:2417838:242622924262292426807579Burkholderia sp. CCGE1002 chromosome chromosome 2, completeRibosomal-protein-alanine N-acetyltransferase2e-1168.9
NC_012225:236490:237677237677238231555Brachyspira hyodysenteriae WA1, complete genomeRibosomal-protein-S5-alanine acetyltransferase4e-1168.2
NC_008800:2592500:260577326057732606357585Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,ribosomal-protein-S5-alanine N-acetyltransferase7e-1167
NC_017138:1812000:183146718314671831997531Bacillus megaterium WSH-002 chromosome, complete genomeribosomal-protein-alanine N-acetyltransferase YjcK3e-1065.1
NC_009092:261778:267039267039267596558Shewanella loihica PV-4, complete genomeGCN5-related N-acetyltransferase3e-1065.1
NC_006155:2378526:238101323810132381597585Yersinia pseudotuberculosis IP 32953, complete genomeribosomal-protein-alanine acetyltransferase3e-1064.7
NC_008149:1718000:172057317205731721157585Yersinia pestis Nepal516, complete genomeribosomal-protein-alanine acetyltransferase3e-1064.7
NC_010634:2297000:229892222989222299506585Yersinia pseudotuberculosis PB1/+, complete genomeGCN5-related N-acetyltransferase3e-1064.7
NC_010159:2546590:256226825622682562852585Yersinia pestis Angola, complete genomeribosomal-protein-alanine acetyltransferase3e-1064.7
NC_010465:2383219:239881823988182399402585Yersinia pseudotuberculosis YPIII, complete genomeGCN5-related N-acetyltransferase3e-1064.7
NC_017243:1323870:132780713278071328304498Brachyspira intermedia PWS/A chromosome, complete genomeRibosomal-protein-S5-alanine acetyltransferase4e-1064.7
NC_005810:2091930:209438720943872094971585Yersinia pestis biovar Microtus str. 91001, complete genomeribosomal-protein-S5-alanine N-acetyltransferase3e-1064.7
NC_008150:1593500:159624515962451596829585Yersinia pestis Antiqua, complete genomeribosomal-protein-alanine acetyltransferase3e-1064.7
NC_004088:2491303:250697925069792507563585Yersinia pestis KIM, complete genomeribosomal-protein-alanine N-acetyltransferase3e-1064.7
NC_017265:2213500:222864322286432229227585Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,ribosomal-protein-S5-alanine N-acetyltransferase3e-1064.7
NC_017168:3433804:344943234494323450016585Yersinia pestis A1122 chromosome, complete genomeribosomal-protein-S5-alanine N-acetyltransferase3e-1064.7
NC_014029:2285323:230096723009672301551585Yersinia pestis Z176003 chromosome, complete genomeribosomal-protein-alanine acetyltransferase3e-1064.7
NC_009708:2347350:236172223617222362306585Yersinia pseudotuberculosis IP 31758 chromosome, complete genomeribosomal-protein-S5-alanine N-acetyltransferase3e-1064.7
NC_009381:1205900:122149212214921222076585Yersinia pestis Pestoides F chromosome, complete genomeribosomal-protein-S5-alanine N-acetyltransferase3e-1064.7
NC_003143:2309500:231195723119572312541585Yersinia pestis CO92, complete genomeribosomal-protein-alanine acetyltransferase3e-1064.7
NC_013406:781308:781308781308782249942Paenibacillus sp. Y412MC10 chromosome, complete genomeGCN5-like N-acetyltransferase1e-0962.8
NC_015566:1941407:195551419555141956071558Serratia sp. AS12 chromosome, complete genomeribosomal-protein-alanine N-acetyltransferase7e-0960.5
NC_005125:2366778:238999223899922390591600Gloeobacter violaceus PCC 7421, complete genomeribosomal-protein-alanine N-acetyltransferase1e-0859.7
NC_013592:1056500:106236110623611062921561Dickeya dadantii Ech586, complete genomeRibosomal-protein-alanine N-acetyltransferase1e-0859.7
NC_006270:741731:745332745332745871540Bacillus licheniformis ATCC 14580, complete genomeputative ribosomal-protein-alanine N-acetyltransferase YjcK2e-0858.9
NC_016940:271500:271930271930272502573Saprospira grandis str. Lewin chromosome, complete genomeribosomal-protein-S5-alanine N-acetyltransferase2e-0755.5
NC_017160:2212806:222846622284662228858393Yersinia pestis D182038 chromosome, complete genomeribosomal-protein-alanine acetyltransferase1e-0652.8
NC_017154:2306421:230907023090702309462393Yersinia pestis D106004 chromosome, complete genomeribosomal-protein-alanine acetyltransferase1e-0652.8
NC_013093:5419458:543464254346425435196555Actinosynnema mirum DSM 43827, complete genomeGCN5-related N-acetyltransferase2e-0652.8
NC_007492:857428:860485860485861072588Pseudomonas fluorescens PfO-1, complete genomeGCN5-related N-acetyltransferase4e-0651.6
NC_007516:2277910:231308523130852313660576Synechococcus sp. CC9605, complete genomeacetyltransferase-like4e-0651.2