Pre_GI: BLASTP Hits

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Query: NC_017026:1095753:1108130 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 1108130, End: 1108786, Length: 657

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016768:3296478:330060233006023301258657Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein3e-82304
NC_012943:3299744:330386833038683304524657Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein3e-82304
NC_009565:1098847:111121111112111111867657Mycobacterium tuberculosis F11, complete genomehypothetical protein3e-82304
NC_009525:1096386:110875111087511109407657Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein1e-81302
NC_000962:1095078:110744311074431108099657Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein1e-81302
NC_002755:1095105:110748211074821108138657Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein1e-81302
NC_012207:1097228:110959311095931110249657Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein3e-81301
NC_015848:1105892:111825011182501118906657Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein3e-81301
NC_008769:1125567:113793211379321138588657Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein3e-81301
NC_002945:1095337:110789411078941108550657Mycobacterium bovis AF2122/97, complete genomehypothetical protein3e-81301
NC_016804:1095846:110821111082111108867657Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein3e-81301
NC_013510:991827:1006923100692310080591137Thermomonospora curvata DSM 43183, complete genomeSAF domain protein4e-0651.6