Pre_GI: BLASTP Hits

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Query: NC_017026:1095753:1106231 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 1106231, End: 1106734, Length: 504

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015848:1105892:1115923111592311170831161Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein4e-70263
NC_002755:1095105:1105155110515511063151161Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein4e-70263
NC_000962:1095078:1105116110511611062761161Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE CONSERVED EXPORTED PROTEIN4e-70263
NC_009565:1098847:1108884110888411100441161Mycobacterium tuberculosis F11, complete genomehypothetical protein4e-70263
NC_009525:1096386:1106424110642411075841161Mycobacterium tuberculosis H37Ra, complete genomeputative conserved exported protein4e-70263
NC_012943:3299744:3305691330569133068511161Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein4e-70263
NC_016768:3296478:3302425330242533035851161Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein4e-70263
NC_002945:1095337:1105567110556711067271161Mycobacterium bovis AF2122/97, complete genomehypothetical protein4e-70263
NC_008769:1125567:1135605113560511367651161Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein4e-70263
NC_012207:1097228:1107266110726611084261161Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein4e-70263
NC_016804:1095846:1105884110588411070441161Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein4e-70263
NC_002939:2337402:2395548239554823967171170Geobacter sulfurreducens PCA, complete genomehypothetical protein3e-29127
NC_007492:2310793:2313904231390423149711068Pseudomonas fluorescens PfO-1, complete genomehypothetical protein3e-1684.3
NC_015733:3595882:3599086359908636001411056Pseudomonas putida S16 chromosome, complete genomeputative lipoprotein1e-1375.5
NC_009952:3522370:3522370352237035234341065Dinoroseobacter shibae DFL 12, complete genomehypothetical protein1e-1169.3
NC_009348:2738742:2742461274246127435281068Aeromonas salmonicida subsp. salmonicida A449, complete genomehypothetical protein2e-1168.2
NC_011662:2402408:2418887241888724200501164Thauera sp. MZ1T, complete genomehypothetical protein1e-1065.9
NC_008700:3514745:3520925352092535221271203Shewanella amazonensis SB2B, complete genomeconserved hypothetical protein4e-1063.9
NC_013939:1902397:1903082190308219041161035Deferribacter desulfuricans SSM1, complete genomehypothetical protein1e-0755.8