Pre_GI: BLASTP Hits

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Query: NC_017026:1095753:1104283 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 1104283, End: 1105791, Length: 1509

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013929:8474195:8503623850362385061332511Streptomyces scabiei 87.22 chromosome, complete genomeABC transporter5e-0653.1
NC_013939:1902397:1899903189990319024042502Deferribacter desulfuricans SSM1, complete genomeABC transporter permease7e-33142
NC_009348:2738742:2740116274011627424642349Aeromonas salmonicida subsp. salmonicida A449, complete genomeABC-type transporter, permease protein1e-21105
NC_009525:1096386:1103850110385011064172568Mycobacterium tuberculosis H37Ra, complete genomeadhesion component ABC transporter permease protein0889
NC_016768:3296478:3303592330359233061592568Mycobacterium tuberculosis KZN 4207 chromosome, complete genomeadhesion component transport transmembrane protein0889
NC_002945:1095337:1102993110299311042641272Mycobacterium bovis AF2122/97, complete genomeadhesion component transport transmembrane protein ABC transporter8e-32138
NC_002945:1095337:1104265110426511055601296Mycobacterium bovis AF2122/97, complete genomeadhesion component transport transmembrane protein ABC transporter0746
NC_009565:1098847:1106310110631011088772568Mycobacterium tuberculosis F11, complete genomehypothetical adhesion component transport transmembrane protein ABC transporter0889
NC_012943:3299744:3306858330685833094252568Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein0889
NC_002755:1095105:1102581110258111051482568Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein0889
NC_015733:3595882:3600131360013136025932463Pseudomonas putida S16 chromosome, complete genomehypothetical protein2e-27124
NC_014168:1294000:1322125132212513246142490Segniliparus rotundus DSM 44985 chromosome, complete genomehypothetical protein1e-0758.2
NC_009952:3522370:3523424352342435258262403Dinoroseobacter shibae DFL 12, complete genomepredicted permease FtsX3e-20100
NC_000962:1095078:1102542110254211051092568Mycobacterium tuberculosis H37Rv, complete genomePROBABLE ADHESION COMPONENT TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER0889
NC_007492:2310793:2311467231146723139142448Pseudomonas fluorescens PfO-1, complete genomeProtein of unknown function DUF2149e-1789
NC_011662:2402408:2420085242008524213111227Thauera sp. MZ1T, complete genomeprotein of unknown function DUF2141e-23111
NC_008700:3514745:3518305351830535209232619Shewanella amazonensis SB2B, complete genomeputative ABC transport system permease protein4e-1583.2
NC_015848:1105892:1113349111334911159162568Mycobacterium canettii CIPT 140010059, complete genomeputative adhesion component transport transmembrane protein ABC transporter0884
NC_008769:1125567:1133031113303111355982568Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative adhesion component transport transmembrane protein ABC transporter0887
NC_012207:1097228:1104692110469211072592568Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative adhesion component transport transmembrane protein ABC transporter0887
NC_016804:1095846:1103310110331011058772568Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative adhesion component transport transmembrane protein ABC transporter0887