Pre_GI: BLASTP Hits

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Query: NC_017026:1095753:1098186 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Start: 1098186, End: 1098617, Length: 432

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002945:1095337:1097959109795910994731515Mycobacterium bovis AF2122/97, complete genometwo component sensor kinase MprB7e-45179
NC_016804:1095846:1098276109827610997901515Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative two component sensor kinase7e-45179
NC_008769:1125567:1127997112799711295111515Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative two component sensor kinase mprB7e-45179
NC_012207:1097228:1099658109965811011721515Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative two component sensor kinase7e-45179
NC_015848:1105892:1108315110831511098291515Mycobacterium canettii CIPT 140010059, complete genomeputative two component sensor kinase MPRB7e-45179
NC_002755:1095105:1097547109754710990611515Mycobacterium tuberculosis CDC1551, complete genomesensor histidine kinase6e-45179
NC_009565:1098847:1101277110127711027911515Mycobacterium tuberculosis F11, complete genometwo component system sensor kinase mprB6e-45179
NC_009525:1096386:1098816109881611003301515Mycobacterium tuberculosis H37Ra, complete genomeputative two component sensor kinase MprB6e-45179
NC_000962:1095078:1097508109750810990221515Mycobacterium tuberculosis H37Rv, complete genomePROBABLE TWO COMPONENT SENSOR KINASE MPRB6e-45179
NC_012943:3299744:3312945331294533144591515Mycobacterium tuberculosis KZN 1435 chromosome, complete genometwo component system sensor kinase mprB6e-45179
NC_016768:3296478:3309679330967933111931515Mycobacterium tuberculosis KZN 4207 chromosome, complete genometwo component system sensor kinase mprB6e-45179