Pre_GI: BLASTP Hits

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Query: NC_016913:974212:977414 Rickettsia rickettsii str. Brazil chromosome, complete genome

Start: 977414, End: 978601, Length: 1188

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017044:178395:1914461914461926151170Rickettsia parkeri str. Portsmouth chromosome, complete genomehypothetical protein0734
NC_009900:180970:1926391926391938141176Rickettsia massiliae MTU5, complete genomehypothetical protein0658
NC_017043:898734:9108939108939120681176Rickettsia montanensis str. OSU 85-930 chromosome, complete genomehypothetical protein0661
NC_016050:182218:1939101939101950851176Rickettsia japonica YH, complete genomehypothetical protein0662
NC_017028:261589:2724852724852736601176Candidatus Rickettsia amblyommii str. GAT-30V chromosome, completehypothetical protein0670
NC_016639:175846:1916231916231927441122Rickettsia slovaca 13-B chromosome, complete genomehypothetical protein0701
NC_012730:652092:6572476572476583681122Rickettsia peacockii str. Rustic, complete genomehypothetical protein0706
NC_017065:175856:1916311916311928001170Rickettsia slovaca str. D-CWPP chromosome, complete genomehypothetical protein0734
NC_017058:1255623:1260677126067712618521176Rickettsia australis str. Cutlack chromosome, complete genomehypothetical protein3e-174611
NC_007109:1206421:1212811121281112139741164Rickettsia felis URRWXCal2, complete genomehypothetical protein3e-170598
NC_009879:141000:1420991420991432051107Rickettsia canadensis str. McKiel, complete genomeMrp protein2e-0654.3
NC_016929:141972:1430571430571441631107Rickettsia canadensis str. CA410 chromosome, complete genomeMrp protein2e-0653.9
NC_009881:562000:5742885742885769002613Rickettsia akari str. Hartford, complete genomeleucyl-tRNA synthetase7e-0652