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Query: NC_016913:974212:974212 Rickettsia rickettsii str. Brazil chromosome, complete genome

Start: 974212, End: 974646, Length: 435

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009900:180970:196555196555197025471Rickettsia massiliae MTU5, complete genomehypothetical protein2e-75280
NC_012730:652092:654000654000654434435Rickettsia peacockii str. Rustic, complete genomehypothetical protein4e-74276
NC_017043:898734:914789914789915223435Rickettsia montanensis str. OSU 85-930 chromosome, complete genomehypothetical protein5e-74275
NC_016050:182218:197856197856198290435Rickettsia japonica YH, complete genomehypothetical protein3e-73273
NC_017058:1255623:125750912575091257943435Rickettsia australis str. Cutlack chromosome, complete genomehypothetical protein2e-68256
NC_006142:140853:173310173310173744435Rickettsia typhi str. Wilmington, complete genomerickettsial conserved hypothetical protein5e-62236
NC_017062:141270:173727173727174161435Rickettsia typhi str. B9991CWPP chromosome, complete genomehypothetical protein5e-62236
NC_017066:140853:173310173310173744435Rickettsia typhi str. TH1527 chromosome, complete genomehypothetical protein5e-62236
NC_007109:1206421:120969812096981210078381Rickettsia felis URRWXCal2, complete genomehypothetical protein2e-60230
NC_017028:261589:276435276435276779345Candidatus Rickettsia amblyommii str. GAT-30V chromosome, completehypothetical protein4e-57219