Pre_GI: BLASTP Hits

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Query: NC_016913:917500:935915 Rickettsia rickettsii str. Brazil chromosome, complete genome

Start: 935915, End: 936046, Length: 132

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016930:228000:231002231002231133132Rickettsia philipii str. 364D chromosome, complete genomehypothetical protein1e-1788.6
NC_016914:231324:233151233151233282132Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein1e-1788.6
NC_016911:232481:233012233012233143132Rickettsia rickettsii str. Hauke chromosome, complete genomehypothetical protein1e-1788.6
NC_016909:230000:232924232924233055132Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein1e-1788.6
NC_010263:232482:233064233064233195132Rickettsia rickettsii str. Iowa, complete genomehypothetical protein1e-1788.6
NC_009882:232400:232970232970233101132Rickettsia rickettsii str. 'Sheila Smith', complete genomeAnkyrin repeat1e-1788.6
NC_015866:233448:235270235270235407138Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein2e-1684.3
NC_016931:232981:232981232981233112132Rickettsia massiliae str. AZT80 chromosome, complete genomehypothetical protein7e-1579.3
NC_017042:310000:313147313147313314168Rickettsia rhipicephali str. 3-7-female6-CWPP chromosome, completehypothetical protein3e-1477.4