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Query: NC_016913:917500:931262 Rickettsia rickettsii str. Brazil chromosome, complete genome

Start: 931262, End: 931414, Length: 153

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016930:228000:235636235636235788153Rickettsia philipii str. 364D chromosome, complete genomehypothetical protein5e-22103
NC_016914:231324:237787237787237939153Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein5e-22103
NC_016911:232481:237648237648237800153Rickettsia rickettsii str. Hauke chromosome, complete genomehypothetical protein5e-22103
NC_016909:230000:237560237560237712153Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein5e-22103
NC_009882:232400:237606237606237758153Rickettsia rickettsii str. 'Sheila Smith', complete genomealpha-ketoglutarate decarboxylase5e-22103
NC_010263:232482:237700237700237852153Rickettsia rickettsii str. Iowa, complete genomehypothetical protein5e-22103