Pre_GI: BLASTP Hits

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Query: NC_016913:917500:923925 Rickettsia rickettsii str. Brazil chromosome, complete genome

Start: 923925, End: 924026, Length: 102

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009882:232400:244994244994245095102Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein3e-1270.5
NC_016930:228000:243023243023243124102Rickettsia philipii str. 364D chromosome, complete genomehypothetical protein1e-1168.9
NC_017058:1200500:120620412062041206314111Rickettsia australis str. Cutlack chromosome, complete genomecation transport regulator ChaB8e-1165.9
NC_010263:232482:245006245006245185180Rickettsia rickettsii str. Iowa, complete genomecation transport regulator5e-1063.2
NC_016909:230000:244866244866245045180Rickettsia rickettsii str. Arizona chromosome, complete genomecation transport regulator5e-1063.2
NC_016911:232481:244954244954245133180Rickettsia rickettsii str. Hauke chromosome, complete genomecation transport regulator5e-1063.2
NC_016914:231324:245093245093245272180Rickettsia rickettsii str. Hino chromosome, complete genomecation transport regulator5e-1063.2
NC_015866:233448:247285247285247386102Rickettsia heilongjiangensis 054 chromosome, complete genomecation transport regulator ChaB5e-1063.2
NC_009900:231983:247334247334247489156Rickettsia massiliae MTU5, complete genome9e-1062.4
NC_017042:310000:325841325841325963123Rickettsia rhipicephali str. 3-7-female6-CWPP chromosome, completecation transport regulator ChaB1e-0962
NC_017028:316000:328203328203328400198Candidatus Rickettsia amblyommii str. GAT-30V chromosome, completecation transport regulator ChaB2e-0961.2
NC_009881:236500:249082249082249276195Rickettsia akari str. Hartford, complete genomeCation transport regulator ChaB3e-0960.8
NC_016931:232981:245556245556245678123Rickettsia massiliae str. AZT80 chromosome, complete genomecation transport regulator ChaB3e-0960.5