Pre_GI: BLASTP Hits

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Query: NC_016913:917500:918130 Rickettsia rickettsii str. Brazil chromosome, complete genome

Start: 918130, End: 918408, Length: 279

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:231324:250785250785251063279Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein3e-48190
NC_016930:228000:248641248641248919279Rickettsia philipii str. 364D chromosome, complete genomehypothetical protein6e-48189
NC_010263:232482:250698250698250901204Rickettsia rickettsii str. Iowa, complete genomehypothetical protein7e-33139
NC_003103:225956:247010247010247210201Rickettsia conorii str. Malish 7, complete genomehypothetical protein1e-32137
NC_016050:236000:253621253621253761141Rickettsia japonica YH, complete genomehypothetical protein7e-1682.4
NC_015866:233448:252551252551252691141Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein3e-1580.5
NC_017042:310000:331125331125331235111Rickettsia rhipicephali str. 3-7-female6-CWPP chromosome, completehypothetical protein1e-1168.6
NC_009881:236500:254761254761255252492Rickettsia akari str. Hartford, complete genomeAnkyrin repeat3e-0960.5