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Query: NC_016913:1066790:1083525 Rickettsia rickettsii str. Brazil chromosome, complete genome

Start: 1083525, End: 1083842, Length: 318

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017044:80384:863518635186668318Rickettsia parkeri str. Portsmouth chromosome, complete genomehypothetical protein2e-44177
NC_016050:73993:879098790988226318Rickettsia japonica YH, complete genomehypothetical protein2e-44177
NC_016931:107880:117663117663117980318Rickettsia massiliae str. AZT80 chromosome, complete genomehypothetical protein4e-44176
NC_009900:73804:863018630186630330Rickettsia massiliae MTU5, complete genomehypothetical protein4e-44176
NC_003103:70000:829378293783254318Rickettsia conorii str. Malish 7, complete genomehypothetical protein7e-44175
NC_009881:70807:784467844678763318Rickettsia akari str. Hartford, complete genomehypothetical protein6e-42169
NC_017058:97810:110893110893111210318Rickettsia australis str. Cutlack chromosome, complete genomehypothetical protein1e-41168
NC_017048:400000:410563410563410874312Rickettsia prowazekii str. GvV257 chromosome, complete genomehypothetical protein9e-33138
NC_017049:58000:686336863368944312Rickettsia prowazekii str. Chernikova chromosome, complete genomehypothetical protein9e-33138
NC_017051:58000:686356863568946312Rickettsia prowazekii str. Dachau chromosome, complete genomehypothetical protein9e-33138
NC_017056:58000:686306863068941312Rickettsia prowazekii str. BuV67-CWPP chromosome, complete genomehypothetical protein9e-33138
NC_016929:55974:680596805968376318Rickettsia canadensis str. CA410 chromosome, complete genomeputative ABC transporter ATP-binding protein2e-31134
NC_009879:57500:672976729767614318Rickettsia canadensis str. McKiel, complete genomeputative ABC transporter ATP-binding component5e-31132
NC_007940:1435701:144205414420541442329276Rickettsia bellii RML369-C, complete genomehypothetical protein4e-1476.6
NC_009883:140890:152277152277152552276Rickettsia bellii OSU 85-389, complete genomehypothetical protein4e-1476.6