Pre_GI: BLASTP Hits

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Query: NC_016913:1066790:1076626 Rickettsia rickettsii str. Brazil chromosome, complete genome

Start: 1076626, End: 1077300, Length: 675

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009879:57500:734727347274143672Rickettsia canadensis str. McKiel, complete genomearginyl-tRNA synthetase2e-108391
NC_016929:55974:742217422174886666Rickettsia canadensis str. CA410 chromosome, complete genomearginyl-tRNA synthetase1e-105382
NC_017044:80384:927349273493408675Rickettsia parkeri str. Portsmouth chromosome, complete genomehypothetical protein2e-123441
NC_009900:73804:933049330493996693Rickettsia massiliae MTU5, complete genomehypothetical protein5e-122436
NC_017049:58000:748817488175549669Rickettsia prowazekii str. Chernikova chromosome, complete genomehypothetical protein5e-97353
NC_016050:73993:946439464395317675Rickettsia japonica YH, complete genomehypothetical protein1e-122438
NC_009881:70807:845958459585269675Rickettsia akari str. Hartford, complete genomehypothetical protein2e-109395
NC_017051:58000:748837488375551669Rickettsia prowazekii str. Dachau chromosome, complete genomehypothetical protein5e-97353
NC_012730:411526:432376432376433050675Rickettsia peacockii str. Rustic, complete genomehypothetical protein3e-123440
NC_017058:97810:119932119932120606675Rickettsia australis str. Cutlack chromosome, complete genomehypothetical protein1e-113408
NC_017056:58000:748787487875546669Rickettsia prowazekii str. BuV67-CWPP chromosome, complete genomehypothetical protein5e-97353
NC_003103:70000:893908939090064675Rickettsia conorii str. Malish 7, complete genomehypothetical protein2e-123441
NC_016931:107880:110284110284110958675Rickettsia massiliae str. AZT80 chromosome, complete genomehypothetical protein7e-122436
NC_017048:400000:416811416811417479669Rickettsia prowazekii str. GvV257 chromosome, complete genomehypothetical protein8e-97352