Pre_GI: BLASTP Hits

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Query: NC_016913:1066790:1070879 Rickettsia rickettsii str. Brazil chromosome, complete genome

Start: 1070879, End: 1071337, Length: 459

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017044:80384:987119871199169459Rickettsia parkeri str. Portsmouth chromosome, complete genomepreprotein translocase subunit SecB1e-84311
NC_017062:61500:811998119981657459Rickettsia typhi str. B9991CWPP chromosome, complete genomepreprotein translocase subunit SecB1e-82304
NC_010793:1628500:162961716296171630111495Orientia tsutsugamushi str. Ikeda, complete genomeprotein-export protein SecB7e-33139
NC_009952:3596399:363014436301443630662519Dinoroseobacter shibae DFL 12, complete genomeprotein-export protein SecB8e-23105
NC_015850:736680:738154738154738603450Acidithiobacillus caldus SM-1 chromosome, complete genomeprotein export cytoplasm chaperone protein1e-22105
NC_008044:3024125:302711530271153027609495Silicibacter sp. TM1040, complete genomeprotein-export protein SecB2e-21101
NC_016616:1336000:133731213373121337776465Dechlorosoma suillum PS chromosome, complete genomeprotein-export chaperone SecB7e-2095.9
NC_012026:75812:906729067291199528Anaplasma marginale str. Florida, complete genomeprotein export chaperone (secB)8e-2095.9
NC_007802:179780:185217185217185732516Jannaschia sp. CCS1, complete genomeprotein-export protein SecB6e-1992.8
NC_013016:419604:419604419604420047444Neisseria meningitidis alpha14 chromosome, complete genomepreprotein translocase subunit SecB2e-1891.7
NC_007508:237771:241429241429241941513Xanthomonas campestris pv. vesicatoria str. 85-10, complete genomeexport protein SecB3e-1890.5
NC_017513:449949:449949449949450392444Neisseria meningitidis G2136 chromosome, complete genomeprotein-export chaperone SecB3e-1890.5
NC_017512:425085:427070427070427513444Neisseria meningitidis WUE 2594, complete genomepreprotein translocase SecB subunit3e-1890.5
NC_003116:658879:660864660864661307444Neisseria meningitidis Z2491, complete genomeexport protein SecB3e-1890.5
NC_008767:451983:451983451983452426444Neisseria meningitidis FAM18, complete genomeputative protein-export protein4e-1890.1
NC_010120:452771:454755454755455198444Neisseria meningitidis 053442, complete genomeprotein-export protein4e-1890.1
NC_017514:446616:448601448601449044444Neisseria meningitidis M01-240149 chromosome, complete genomeprotein-export chaperone SecB4e-1890.1
NC_017518:577159:579144579144579587444Neisseria meningitidis NZ-05/33 chromosome, complete genomeprotein-export chaperone SecB4e-1890.1
NC_007354:1087456:108826210882621088795534Ehrlichia canis str. Jake, complete genomeprotein export chaperone SecB6e-1786.3
NC_016816:127802:171275171275171745471Pantoea ananatis LMG 5342, complete genomeprotein-export protein SecB7e-1579.3
NC_010468:80000:104451104451104918468Escherichia coli ATCC 8739, complete genomeprotein-export protein SecB2e-1478.2
NC_007520:2128178:214600121460012146450450Thiomicrospira crunogena XCL-2, complete genomeprotein-export protein SecB3e-1477.8
NC_015572:293665:295468295468295944477Methylomonas methanica MC09 chromosome, complete genomeProtein-export protein secB2e-1477.8
NC_013892:4129500:415011441501144150587474Xenorhabdus bovienii SS-2004 chromosome, complete genomemolecular chaperone in protein export, enhances activity of SecA (General Secretory Pathway)2e-1477.8
NC_004337:3590323:375625737562573756724468Shigella flexneri 2a str. 301, complete genomeexport protein SecB5e-1476.6
CP002516:88500:112880112880113347468Escherichia coli KO11, complete genomeprotein-export protein SecB5e-1476.6
NC_012947:94930:119543119543120010468Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completepreprotein translocase subunit SecB5e-1476.6
NC_016902:88500:112880112880113347468Escherichia coli KO11FL chromosome, complete genomeprotein-export protein SecB5e-1476.6
NC_020418:603750:608094608094608567474Morganella morganii subsp. morganii KT, complete genomeProtein export cytoplasm chaperone protein6e-1476.3
NC_013851:3392644:341519834151983415671474Allochromatium vinosum DSM 180 chromosome, complete genomeprotein-export protein SecB5e-1373.2
NC_015696:105748:112992112992113441450Francisella sp. TX077308 chromosome, complete genomeprotein export cytoplasm chaperone protein SecB4e-1270.5
NC_010336:733751:746984746984747433450Francisella philomiragia subsp. philomiragia ATCC 25017, completepreprotein translocase, subunit B4e-1270.1