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Query: NC_016913:1066790:1069119 Rickettsia rickettsii str. Brazil chromosome, complete genome

Start: 1069119, End: 1069940, Length: 822

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:99184:9918499184100005822Rickettsia rickettsii str. Hino chromosome, complete genome7-cyano-7-deazaguanine reductase1e-156552
NC_017044:80384:100111100111100932822Rickettsia parkeri str. Portsmouth chromosome, complete genome7-cyano-7-deazaguanine reductase5e-155546
NC_017066:57571:790647906479882819Rickettsia typhi str. TH1527 chromosome, complete genome7-cyano-7-deazaguanine reductase1e-140498
NC_017062:61500:794817948180299819Rickettsia typhi str. B9991CWPP chromosome, complete genome7-cyano-7-deazaguanine reductase1e-140498
NC_006142:57571:790647906479882819Rickettsia typhi str. Wilmington, complete genomehypothetical protein1e-140498
NC_009881:92929:929299292993750822Rickettsia akari str. Hartford, complete genome7-cyano-7-deazaguanine reductase3e-137487
NC_008027:3953951:397709339770933977923831Pseudomonas entomophila L48, complete genomeGTP cyclohydrolase I2e-65249
NC_020209:945000:945060945060945890831Pseudomonas poae RE*1-1-14, complete genome7-cyano-7-deazaguanine reductase1e-63243
NC_020211:4484817:450244345024434503282840Serratia marcescens WW4, complete genome7-cyano-7-deazaguanine reductase2e-63242
NC_015566:4662171:466304546630454663887843Serratia sp. AS12 chromosome, complete genomeNADPH-dependent 7-cyano-7-deazaguanine reductase6e-63241
NC_016830:4639388:466022646602264661056831Pseudomonas fluorescens F113 chromosome, complete genomeNADPH dependent preQ0 reductase5e-63241
NC_014837:3633378:364670836467083647538831Pantoea sp. At-9b chromosome, complete genome7-cyano-7-deazaguanine reductase6e-61234
NC_014012:1421979:142334914233491424206858Shewanella violacea DSS12, complete genomeGTP cyclohydrolase I family protein9e-60230
NC_009655:1357486:135885613588561359695840Actinobacillus succinogenes 130Z chromosome, complete genome7-cyano-7-deazaguanine reductase7e-55214
NC_004556:1611973:162886216288621629689828Xylella fastidiosa Temecula1, complete genomehypothetical protein6e-51201
NC_002488:2235883:225488922548892255716828Xylella fastidiosa 9a5c, complete genomehypothetical protein4e-51201
NC_010513:1590758:161230516123051613132828Xylella fastidiosa M12 chromosome, complete genome7-cyano-7-deazaguanine reductase8e-51200
NC_020410:1301500:130607413060741306568495Bacillus amyloliquefaciens subsp. plantarum UCMB5036 completeNADPH-dependent 7-cyano-7-deazaguanine reductase4e-0858.5
NC_017195:1411936:141879514187951419292498Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, complete7-cyano-7-deazaguanine reductase, putative6e-0858.2
NC_015634:2991669:300657230065723007072501Bacillus coagulans 2-6 chromosome, complete genome7-cyano-7-deazaguanine reductase4e-0755.5
NC_012559:1064821:109090010909001091331432Laribacter hongkongensis HLHK9, complete genomeGTP cyclohydrolase I9e-0754.3