Pre_GI: BLASTP Hits

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Query: NC_016911:771916:786127 Rickettsia rickettsii str. Hauke chromosome, complete genome

Start: 786127, End: 786369, Length: 243

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:772025:786236786236786520285Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein1e-39161
NC_010263:771901:786112786112786396285Rickettsia rickettsii str. Iowa, complete genomehypothetical protein1e-39161
NC_016909:771542:785752785752785994243Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein2e-39160
NC_015866:767790:781815781815782096282Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein7e-33139
NC_016112:1330500:135149513514951351773279Methylomicrobium alcaliphilum chromosome, complete genomehypothetical protein3e-0960.5
NC_008609:975867:992583992583992870288Pelobacter propionicus DSM 2379, complete genomehypothetical protein4e-0960.1
NC_008740:2989856:299894729989472999219273Marinobacter aquaeolei VT8, complete genomehypothetical protein1e-0755.1
NC_002967:1844000:187166118716611871951291Treponema denticola ATCC 35405, complete genomehypothetical protein7e-0752.8
NC_009881:724269:740902740902741069168Rickettsia akari str. Hartford, complete genomehypothetical protein7e-0649.3
NC_017098:1149145:116769211676921167973282Spirochaeta africana DSM 8902 chromosome, complete genomehypothetical protein7e-0649.3