Pre_GI: BLASTP Hits

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Query: NC_016911:771916:783974 Rickettsia rickettsii str. Hauke chromosome, complete genome

Start: 783974, End: 784729, Length: 756

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:772025:784083784083784838756Rickettsia rickettsii str. Hino chromosome, complete genomehemolysin3e-143507
NC_016909:771542:783599783599784354756Rickettsia rickettsii str. Arizona chromosome, complete genomehemolysin3e-143507
NC_010263:771901:783959783959784714756Rickettsia rickettsii str. Iowa, complete genomehemolysin3e-143507
NC_015866:767790:779680779680780435756Rickettsia heilongjiangensis 054 chromosome, complete genomehemolysin4e-141500
NC_016050:771752:783757783757784512756Rickettsia japonica YH, complete genomehemolysin A4e-141500
NC_017058:671000:674995674995675738744Rickettsia australis str. Cutlack chromosome, complete genomehemolysin A1e-128459
NC_009881:724269:738643738643739386744Rickettsia akari str. Hartford, complete genomeHemolysin A3e-128457
NC_009879:475500:480266480266481120855Rickettsia canadensis str. McKiel, complete genometyrosyl-tRNA synthetase2e-125448
NC_016929:474000:479292479292480146855Rickettsia canadensis str. CA410 chromosome, complete genometyrosyl-tRNA synthetase2e-125448
NC_017066:683000:694687694687695442756Rickettsia typhi str. TH1527 chromosome, complete genomehemolysin1e-123442
NC_017062:685321:695255695255696010756Rickettsia typhi str. B9991CWPP chromosome, complete genomehemolysin1e-123442
NC_006142:683000:694675694675695430756Rickettsia typhi str. Wilmington, complete genomehemolysin1e-123442
NC_000963:676000:688129688129688884756Rickettsia prowazekii str. Madrid E, complete genomeHEMOLYSIN (tlyA)1e-121435
NC_017048:1018000:103029610302961031051756Rickettsia prowazekii str. GvV257 chromosome, complete genomehemolysin (tlyA)1e-121435
NC_017049:675261:686254686254687009756Rickettsia prowazekii str. Chernikova chromosome, complete genomehemolysin (tlyA)1e-121435
NC_017050:676000:688123688123688878756Rickettsia prowazekii str. Katsinyian chromosome, complete genomehemolysin (tlyA)1e-121435
NC_017051:674000:686266686266687021756Rickettsia prowazekii str. Dachau chromosome, complete genomehemolysin (tlyA)1e-121435
NC_017056:678450:688100688100688855756Rickettsia prowazekii str. BuV67-CWPP chromosome, complete genomehemolysin (tlyA)1e-121435
NC_017057:679113:688386688386689141756Rickettsia prowazekii str. RpGvF24 chromosome, complete genomehemolysin (tlyA)1e-121435
NC_007940:669143:671746671746672495750Rickettsia bellii RML369-C, complete genomeHemolysin A4e-114410
NC_009883:641491:644094644094644843750Rickettsia bellii OSU 85-389, complete genomeHemolysin A5e-114410
NC_017059:1727095:174623017462301747222993Rhodospirillum photometricum DSM 122, complete genomeHemolysin A2e-55215
NC_006526:1303635:132046913204691321218750Zymomonas mobilis subsp. mobilis ZM4, complete genomepredicted rRNA methylase7e-48190
NC_018145:50237:520535205352802750Zymomonas mobilis subsp. mobilis ATCC 29191 chromosome, completehemolysin A2e-47189
NC_018645:2301705:232280223228022323575774Desulfobacula toluolica Tol2, complete genomehemolysine A-like rRNA methylase7e-46184
NC_016629:3543432:354545235454523546201750Desulfovibrio africanus str. Walvis Bay chromosome, completehemolysin A5e-45181
NC_014960:1735786:178055717805571781375819Anaerolinea thermophila UNI-1, complete genomeputative hemolysin6e-43174
NC_016593:2447938:248112724811272481975849Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completehypothetical protein2e-40165
NC_013894:672840:706959706959707735777Thermocrinis albus DSM 14484 chromosome, complete genomehemolysin A3e-40165
NC_009699:2056500:206525320652532066074822Clostridium botulinum F str. Langeland chromosome, complete genomehemolysin A5e-40164
NC_017297:2054000:206535120653512066172822Clostridium botulinum F str. 230613 chromosome, complete genomehemolysin A5e-40164
NC_010520:2061502:207301520730152073836822Clostridium botulinum A3 str. Loch Maree, complete genomehemolysin A5e-40164
NC_010516:1999500:200819220081922009013822Clostridium botulinum B1 str. Okra, complete genomehemolysin A4e-40164
NC_010794:303203:336497336497337249753Methylacidiphilum infernorum V4, complete genomerRNA methylase1e-39162
NC_011725:4159000:417973141797314180570840Bacillus cereus B4264 chromosome, complete genomehemolysin A2e-39162
NC_013939:913890:942705942705943511807Deferribacter desulfuricans SSM1, complete genomehemolysin A1e-38160
NC_011661:1049767:106263010626301063445816Dictyoglomus turgidum DSM 6724, complete genomehemolysin A3e-38158
NC_014974:758129:775225775225775959735Thermus scotoductus SA-01 chromosome, complete genomeribosomal RNA large subunit methyltransferase J3e-38158
NC_017219:2014605:203291820329182033691774Bifidobacterium longum subsp. infantis ATCC 15697, complete genomehypothetical protein3e-37155
NC_014654:1548194:155793615579361558769834Halanaerobium sp. 'sapolanicus' chromosome, complete genomehemolysin A3e-37155
NC_011593:2014787:203310020331002033930831Bifidobacterium longum subsp. infantis ATCC 15697 chromosome,hemolysin A3e-37155
NC_016047:2480921:250352125035212504366846Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completehemolysin A1e-36152
NC_008312:5903000:592374459237445924598855Trichodesmium erythraeum IMS101, complete genomehemolysin A6e-36150
NC_014833:2225233:222609822260982226889792Ruminococcus albus 7 chromosome, complete genomehemolysin A3e-35148
NC_013192:305478:340793340793341530738Leptotrichia buccalis DSM 1135, complete genomehemolysin A5e-35147
NC_017301:1037519:103751910375191038340822Corynebacterium pseudotuberculosis C231 chromosome, completeHemolysin A1e-34146
NC_018720:1336839:135807613580761358885810Bifidobacterium asteroides PRL2011 chromosome, complete genomehemolysin A6e-34144
NC_006360:221345:246647246647247360714Mycoplasma hyopneumoniae 232, complete genomeTlyA haemolysin8e-34144
NC_018607:1463918:146391814639181464640723Brachyspira pilosicoli B2904 chromosome, complete genomehemolysin A2e-33142
NC_014150:3139852:314432131443213145043723Brachyspira murdochii DSM 12563 chromosome, complete genomehemolysin A2e-33142
NC_019908:499929:523780523780524502723Brachyspira pilosicoli P43/6/78 chromosome, complete genomehemolysin A2e-33142
NC_016783:1169821:117597611759761176797822Corynebacterium diphtheriae INCA 402 chromosome, complete genomeputative cytotoxin/hemolysin2e-32139
NC_013510:2521186:254395825439582544764807Thermomonospora curvata DSM 43183, complete genomehemolysin A3e-32138
NC_015588:1463628:148027614802761481196921Isoptericola variabilis 225 chromosome, complete genomehemolysin A1e-29130
NC_012803:1552122:155506215550621555904843Micrococcus luteus NCTC 2665, complete genomehemolysin A1e-28126
NC_005955:427142:437704437704438237534Bartonella quintana str. Toulouse, complete genomeHemolysin-like protein3e-28125
NC_009718:731670:753818753818754609792Fervidobacterium nodosum Rt17-B1, complete genomehemolysin A2e-27122
NC_014532:1191267:120590512059051206660756Halomonas elongata DSM 2581, complete genomeK06442 putative hemolysin3e-24112